Papers - IWATA Hisataka
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Modification of mitochondrial function, cytoplasmic lipid ontent and cryosensitivity of bovine embryos by resveratrol Reviewed
Abe T, Kawahara-Miki R, Hara T, Noguchi T, Hayashi T, Shirasuna K, Kuwayama T, Iwata H.
Journal of Reproduction and Development 63 ( 5 ) 455 - 461 2017.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Age-associated changes in granulosa cells and follicular fluid in cows. Invited Reviewed
Hisataka Iwata
Journal of Reproduction and Development 63 ( 4 ) 339 - 345 2017.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Age-associated deterioration in follicular fluid induces a decline in bovine oocyte quality Reviewed
Takeo S, Kimura K, Shirasuna K, Kuwayama T, Iwata H
Reproduction Fertility and Development 29 ( 4 ) 759 - 767 2017.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Promotion of glucose utilization by insulin enhances granulosa cell proliferation and developmental competence of porcine oocyte grown in vitro Reviewed
Itami N, Munakata Y, Shirasuna K, Kuwayama T, Iwata H.
Zygote 25 ( 1 ) 65 - 74 2017.02
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Polyacrylamide gel as a culture substrate improves in vitro oocyte growth from porcine early Reviewed
Munakata Y, Kawahara-Miki R, Shirasuna K, Kuwayama T, Iwata H.
Molecular Reproduction and Development 84 ( 1 ) 44 - 54 2017.01
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/mrd.22758.
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Low oxygen Reviewed
Shiratsuki S, Hara T, Munakata Y, Shirasuna K, Kuwayama T, Iwata H.
Molecular and Cellular Endocrinology 437 75 - 85 2016.12
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
顆粒層細胞が卵胞峰内で増殖するメカニズムはHIF1からVEGF,AKT-mTORの経路を介していることを明らかにした。
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Addition of granulosa cell mass to the culture medium of oocytes derived from early antral follicles increases oocyte growth, ATP content, and acetylation of H4K12. Reviewed
Sugiyama M, Sumiya M, Shirasuna K, Kuwayama T, Iwata H.
Zygote 24 ( 6 ) 848 - 856 2016.12
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Relationship between the number of cells surrounding oocytes and energy Reviewed
Munakata Y, Ichinose T, Ogawa K, Itami N, Tasaki H, Shirasuna K, Kuwayama T,Iwata H
Theriogenology 89 ( 7 ) 1789 - 1798 2016.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
卵子を取り巻く細胞の数が卵子の脂質含量、ATPそしてアセチル化を決定していることを明らかにした。
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Gene expression of granulosa cells and oocytes in various stages of follicle and in vitro grown oocytes and granulosa cell complexes Reviewed
Munakata Y, R Kawahara-Miki, S Shiratuski, H Tasaki, N Itami, K Shirasuna, T Kuwayama, H Iwata
Journal of Reproduction and Development 62 ( 4 ) 359 - 366 2016.08
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Age-associated events in bovine oocytes and possible countermeasures Invited Reviewed
Hisataka Iwata
Reproductive medicine and Biology 15 ( 3 ) 155 - 164 2016.07
Language：English Publishing type：Research paper (scientific journal)
加齢に伴う卵子の変化とその対処方法について概説した
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Maternal aging and mitochondria in oocytes Invited Reviewed
23 ( 2 ) 141 - 146 2016.06
Language：Japanese Publishing type：Research paper (scientific journal)
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Liver condition of Holstein cows affects mitochondrial function and fertilization ability of oocytes. Reviewed
Tanaka H, Takeo S, Abe T, Kin A, Shirasuna K, Kuwayama T, Iwata H
Journal of Reproduction and Development 62 ( 3 ) 235 - 240 2016.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
肝臓の疾患が卵子のミトコンドリアと受精率に及ぼす影響について明らかにした
DOI： 10.1071/RD15228
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ウシ卵巣中の卵胞数と加齢の関係 Reviewed
伊丹暢彦・岩田尚孝
日本胚移植学雑誌 37 ( 3 ) 113 - 117 2015.09
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
加齢に伴うウシの卵子数の減少・小卵胞の質の低下について紹介した
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加齢がウシ卵子の発育能力とミトコンドリアに及ぼす影響 Invited Reviewed
白築章互・岩田尚孝
日本胚移植学雑誌 37 ( 3 ) 119 - 125 2015.09
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
加齢に伴うウシの卵子のミトコンドリアの質の減退とレスベラトロールを用いた対処方法について紹介した
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加齢ウシの卵胞液の性状と卵子の体外成熟 Invited Reviewed
竹尾駿 ・岩田尚孝
日本胚移植雑誌 37 ( 3 ) 127 - 131 2015.09
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
加齢に伴うウシの卵胞液の性状変化と卵子の質低下に及ぼす影響について紹介した
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Mitochondrial biogenesis and degradation are induced by CCCP treatment of porcine oocytes. Reviewed
Itami N, Shiratsuki S, Shirasuna K, Kuwayama T, Iwata H.
Reproduction 150 ( 2 ) 97 - 104 2015.05
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
ミトコンドリアを人為的に機能不全にすると卵子中では新たなミトコンドリアの合成と分解が起こり卵子の能力が回復することを示した。
DOI： 10.1530/REP-15-0037.
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Resveratrol improves the quality of pig oocytes derived from early antral follicles through SIRT1 activation Reviewed
N Itami, K Shirasuna, T Kuwayama, H Iwata
Theriogenology 83 ( 8 ) 1360 - 1367 2015.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
レスベラトロールはブタの小卵胞の発育を改善し、卵子中に蓄える脂の量を減らす。また卵子のミトコンドリアの機能を改善する
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Effect of 5-aminoimidazole-4-carboxamide-ribonucleoside on the mitochondrial function and developmental ability of bovine oocytes Reviewed
Shun Takeo, Takahito Abe, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata
Theriogenology 84 ( 4 ) 490 - 497 2015.03
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
AICARで成熟中の卵子のAMPKを活性化するとミトコンドリアの機能がが改善しウシ卵子の能力が改善することを示した
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Effects of reaggregated of granulosa cells and oocytes derived from early antral follicles on the properties of oocytes grown in vitro Reviewed
Ayano Oi, Hidetaka Tasaki, Yasuhisa Munakata, Koumei Shirasuna, Takehito Kuwayama, and Hisataka Iwata
Journal of Reproduction and Development 61 ( 3 ) 191 - 197 2015.02
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
ブタの初期胞状卵胞を用いて細胞と顆粒層細胞をいったん剥離してもその後共培養することで卵子卵丘細胞複合体を再形成し卵子を体外発育させることができることを示した。
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Age-associated changes in bovine oocytes and granulosa cell complexes collected from early antral follicles. Reviewed
Itami N, Kawahara-Miki R, Kawana H, Endo M, Kuwayama T, Iwata H
J Assist Reprod Genet 2014.05
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
加齢ウシの初期胞状卵胞の顆粒層細胞の遺伝子発現プロファイルはすでに退行様になっているために体外発生能力が若齢のそれに比べて低いことを示した。