Papers - SHIRASUNA Koumei
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Short-term heat stress induces mitochondrial degradation and biogenesis and enhances mitochondrial quality in porcine oocytes. Reviewed
Itami N, Shirasuna K, Kuwayama T, Iwata H
J Therm Biol 74 256 - 263 2018
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces ceramide accumulation, mitochondrial protein hyper-acetylation and micochondrial dysfunction in porcine oocytes Reviewed
Itami N, Shirasuna K, Kuwayama T, Iwata H
Biol Reprod 98 644 - 653 2018
Language：English Publishing type：Research paper (scientific journal)
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Galectin-1 as a novel risk factor for both gestational hypertention and preeclampsia, specifically its expression at a low level in the second trimester and high level after onset. Reviewed
Hirashima C, Ohkuchi A, Nagayama S, Suzuki H, Takahashi K, Ogoyama M, Takahashi H, Shirasuna K, Matsubara S
Hypertens Res 41 45 - 52 2018
Language：English Publishing type：Research paper (scientific journal)
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Advanced glycation end products and lipopolysaccharide stimulate interleukin-6 secretion via RAGE/TLR4-NF-kB-ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages. Reviewed
Ohtsu A, Shibutani Y, Seno K, Iwata H, Kuwayama T, Shirasuna K.
Experimental and Therapeutic Medicine 14 4364 - 4370 2017
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid stimulates interleukin-8 via the TLR4/NF-kB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells. Reviewed
Ohtsu A, Tanaka H, Seno K, Iwata H, Kuwayama T, Shirasuna K.
Am J Reprod Immunol 2017
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Advanced glycation end products regulate interleukin-1β production in human placenta. Reviewed
Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
J Reprod Dev 63 401 - 408 2017
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Effect of aging on the female reproductive function. Invited Reviewed
Shirasuna K, Iwata H.
Contraception and Reproductive Medicine 2 ( 23 ) 2017
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Interferon tau regulates cytokine production and cellular function in human trophoblast cell line. Reviewed
Tanikawa N, Seno K, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K
J Interferon & Cytokine Research 37 456 - 466 2017
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Age-associated mRNA expression changes in bovine endometrial cells in vitro. Reviewed
Tanikawa N, Ohtsu A, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K
Reprod Biol Endocrinol 15 ( 63 ) 2017
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Maternal aging affects oocyte resilience to carbonyl cyanide-m-chlorophenylhydrazone-induced mitochondrial dysfunction in cows. Reviewed
Kansaku K, Takeo S, Itami N, Kin A, Shirasuna K, Kuwayama T, Iwata H
PLoS One 12 e0188099 2017
Language：English Publishing type：Research paper (scientific journal)
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Independent risk factors for a small placenta and a small-for-gestational-age infant at 35-41 weeks of gestation: An association with circulating angiogenesis-related factor levels at 19-31 weeks of gestation. Reviewed
Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Shirasuna K, Matsubara S
J Obestet Gynaecol Res 43 1285 - 1292 2017
Language：English Publishing type：Research paper (scientific journal)
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Promotion of glucose utilization by insulin enhances granulosa cell proliferation and developmental competence of porcine oocyte growth in vitro. Reviewed
Itami N, Munakata Y, Shirasuna K, Kuwayama T, Iwata H
Zygote 25 65 - 74 2017
Language：English Publishing type：Research paper (scientific journal)
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AGEs and HMGB1 increase inflammatory cytokine production from human placental cells, resulting in an enhancement of monocyte migration. Reviewed
Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
Am J Reprod Immunol 2016 ( 75 ) 557 - 568 2016
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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NLRP3 deficiency reduces macrophage interleukin-10 production and enhances the susceptibility to doxorubicin-induced cardiotoxicity. Reviewed
Kobayashi M, Usui F, Karasawa T, Kawashima A, Kimura H, Mizushina Y Shirasuna K, Mizukami H, Kasahara T, Hasebe N, Takahashi M.
Scientific Reports 6 2648 2016
Language：English Publishing type：Research paper (scientific journal)
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Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during post-ovulatory phase. Reviewed
Tanaka H, Ohtsu A, Shiratsuki S, Kawahara-Miki R, Iwata H, Kuwayama T, Shirasuna K.
Mol Reprod Dev 2016 ( 83 ) 815 - 826 2016
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. Reviewed
Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
J Reprod Immunol 2016 ( 116 ) 104 - 112 2016
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Low oxygen level increases proliferation and metabolic changes in bovine granulosa cells. Reviewed
Shiratsuki S, Hara T, Munakata K, Shirasuna K, Kuwayama T, Iwata H
Mol Cell Endocrinol 437 75 - 85 2016
Language：English Publishing type：Research paper (scientific journal)
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Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC Reviewed
Shirasuna K, Usui F, Karasawa T, Kimura H, Kawashima A, Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M.
Nanotoxicology 2015 ( 9 ) 554 - 567 2015.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Moderate hypoxia down-regulates interleukin-6 and TLR4 expression in human Sw.71 placental cells Reviewed
Shirasuna K, Shimamura N, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T
Cell Physiol Biochem 2015 ( 36 ) 2149 - 2160 2015
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy. Reviewed
Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura H, Kawashima A, Ohkuchi A, Taniguchi S, Takahashi M.
Endocrinology 2015 ( 156 ) 4281 - 4292 2015
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)