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Naoto Tanaka Professor |
From Graduate School 【 display / non-display 】
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Tokyo University of Agriculture Doctoral program (second term) Completed
1998.04 - 2001.03
Country：Japan
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Tokyo University of Agriculture Doctoral program (first term) Completed
1996.04 - 1998.03
Country：Japan
Degree 【 display / non-display 】
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博士（農芸化学） ( 2001.03 東京農業大学 )
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修士（農芸化学） ( 1998.03 東京農業大学 )
Employment Record in Research 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Applied Biology and Chemistry
2001.04 - 2001.06
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Tokyo University of Agriculture Faculty of Applied Bio-Science Culture Collection Center Lecturer
2007.04 - 2010.09
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Tokyo University of Agriculture Graduate School of Agriculture Department of Environmental Symbiotic Studies Lecturer
2009.04 - 2010.09
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Tokyo University of Agriculture Graduate School of Agriculture Department of Environmental Symbiotic Studies Associate Professor
2010.10 - 2013.03
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Tokyo University of Agriculture Faculty of Applied Bio-Science Associate Professor
2010.10 - 2015.03
Papers 【 display / non-display 】
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Antimicrobial activity, genome analysis, and gene cluster encoding the plantaricin production of Lactiplantibacillus plantarum ZBK1-5 Reviewed International coauthorship International journal
N. Choovet, T. Jirakanjanasit, P. Subphon, S. Thepsombat, E. Kingkaew, N. Tanaka, Y. Shiwa, S. Tanasupawat, S. Phuengjayaem
ScienceAsia 50 ( 1 ) 1 - 12 2024.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Science Society of Thailand
This study aimed to explore bacteriocin-producing lactic acid bacteria (LAB), identify the genes influencing bacteriocin synthesis, and assess their probiotic potential via safety evaluations both in vitro and in silico. The strain ZBK1-5, isolated from pickled ginger, was identified as Lactiplantibacillus plantarum. The bacteriocin ZBK1-5 exhibited the highest antimicrobial activity with 6,400 AU/ml at 18 h, predominantly effective against Gram-positive bacteria and stable within pH 2?9. Significantly, the genome analysis confirmed the existence of bacteriocin synthesis genes, specifically plantaricin KJ, EF, A, and N. Simultaneously, the safety evaluations showed its low risk of antibiotic resistance gene transfer, thereby emphasizing the safety profile of the strain ZBK1-5. The genetic components associated with the ability of L. plantarum ZBK1-5 to survive and adapt in gastrointestinal conditions provide additional evidence (16 genes related to acid stress and 9 genes associated with bile resistance), supporting its potential as a probiotic candidate. These findings were validated through in vitro digestion conditions, where the viability of the cells was observed to be 68.26, 66.62, and 60.91% during transit through the oral, gastrointestinal, and small intestinal phases, respectively. Additionally, the strain ZBK1-5 showed a 90.39% adhesion rate in the Caco-2 cell line. The unique characteristics of plantaricin produced by L. plantarum ZBK1-5 exhibit potent antibacterial activity, rapid time to production compared to other known plantaricins, and strain safety for application and upscaling. This research study offers significant scientific insights into L. plantarum ZBK1-5, a plantaricin producer, emphasizing its promising potential for future applications.
DOI： 10.2306/scienceasia1513-1874.2024.046
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Chromosome-level genome assemblies of Cutaneotrichosporon spp. (Trichosporonales, Basidiomycota) reveal imbalanced evolution between nucleotide sequences and chromosome synteny Reviewed International journal
Yuuki Kobayashi, Ayane Kayamori, Keita Aoki, Yuh Shiwa, Minenosuke Matsutani, Nobuyuki Fujita, Takashi Sugita, Wataru Iwasaki, Naoto Tanaka & Masako Takashima
BMC Genomics 24 609 2023.10
Language：English Publishing type：Research paper (scientific journal)
Since DNA information was first used in taxonomy, barcode sequences such as the internal transcribed spacer (ITS) region have greatly aided fungal identification; however, a barcode sequence alone is often insufficient. Thus, multi-gene- or whole-genome-based methods were developed. We previously isolated Basidiomycota yeasts classified in the Trichosporonales. Some strains were described as Cutaneotrichosporon cavernicola and C. spelunceum, whereas strain HIS471 remained unidentified. We analysed the genomes of these strains to elucidate their taxonomic relationship and genetic diversity.
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Characterization and genomic analysis of Fererhizobium litorale gen. nov., sp. nov., isolated from the sandy sediments of the Sea of Japan seashore. Reviewed International coauthorship International journal
Lyudmila Romanenko, Nadezhda Otstavnykh, Naoto Tanaka, Valeriya Kurilenko, Vasily Svetashev, Liudmila Tekutyeva, Valery Mikhailov, Marina Isaeva
Microorganisms 11 2385 2023.09
Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI journals
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Hyphal growth in Trichosporon asahii is accelerated by the addition of magnesium Reviewed International journal
Keita Aoki, Kosuke Yamamoto, Moriya Ohkuma, Takashi Sugita, Naoto Tanaka, and Masako Takashima
Microbiology Spectrum 2023.04
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Weizmannia acidilactici sp. nov., a lactic acid producing bacterium isolated from soils Reviewed International coauthorship International journal
Vasana Tolieng, Naoto Tanaka, Yuh Shiwa, Sitanan Thitiprasert, Pawina Kanchanasin, Wongsakorn Phongsopitanun, Auttaporn Booncharoen, Nuttha Thongchul, Somboon Tanasupawat
Syst Appl Microbiol 46 ( 1 ) 2022.12
Language：English Publishing type：Research paper (scientific journal)
Books and Other Publications 【 display / non-display 】
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田中尚人（ Role： Joint author , 東京農業大学の乳酸菌コレクション）
(株)エヌ・ティー・エス 2023.09 （ ISBN:978-4-86043-858-6 ）
Language：Japanese Book type：General book, introductory book for general audience
生物資源として、生きた研究材料として重要性が高まる中、研究の発展に寄与する微生物資源の利活用について解説している。また、微生物メタゲノム情報の解析や環境サンプルの直接研究により明らかになりつつ微生物の多様性・生態について記載している。
Misc 【 display / non-display 】
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乳酸菌を分離するための基本 Invited Reviewed
田中尚人
日本乳酸菌学会誌 30 ( 1 ) 3 - 7 2019.03
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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ユーザーの求める機能性乳酸菌株のオンライン選抜システムの開発
田中尚人，宮崎智，鈴木智典，冨田理，梶川揚申，内野昌孝，五十君靜信，岡田早苗
日本微生物資源学会誌 33 ( 1 ) 31 - 37 2017.06
Authorship：Lead author Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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デルブレッキー菌は変な乳酸菌
田中尚人
生物工学会会誌 95 ( 4 ) 207 2017.04
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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これからのハラール研究
阿部尚樹、内野昌孝、野口治子、田中尚人、岡大貴
食品機械装置 2016.05
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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ヒトの暮らしに貢献する乳酸菌 その３
田中 尚人
醤油の研究と技術 41 ( 5 ) 317 - 320 2015.09
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：一般財団法人日本醤油技術センター
乳酸菌の性質がヒトの生活にどのようにリンクしているか、代謝産物であればエコールやバニリンなどの酸化還元物質の影響、菌体であれば免疫調節作用が実際にどのように作用しているか概要を説明し、発酵については微生物間の生存競争のために必要な環境の酸性化が関わっているなどそれぞれ具体的な例を挙げながら微生物学的視点からの考察を加えて解説した。
Past of Cooperative Research 【 display / non-display 】
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発酵食品由来微生物の分類学的研究
2014.09 - 2017.03
独立行政法人製品評価技術基盤機構 国内共同研究 Cooperative Research within Japan
国内外発酵食品由来乳酸菌の系統分布の解析および新種提唱
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新規機能性乳酸菌資源開発の共同事業
2011.08 - 2014.03
独立行政法人製品評価技術基盤機構 国内共同研究 Cooperative Research within Japan
モンゴルの乳酸菌の分離及び系統解析による系統的分布と応用利用のための性状解析
Presentations 【 display / non-display 】
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Comparative genomics for reclassification of Stenotrophomonas maltophilia reference strains and biovar II group International conference
2022.03
Event date： 2022.03
Language：Japanese Presentation type：Oral presentation (general)
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Characterization of biofilm formation and constituent bacterial species by addition of siderophores to environmental samples International conference
2022.03
Event date： 2022.03
Language：Japanese Presentation type：Oral presentation (general)
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Analysis of mating-type loci of Cutaneotrichosporon cavernicola strains by comparative genomics International conference
2022.03
Event date： 2022.03
Language：Japanese Presentation type：Oral presentation (general)
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Effects of biodegradable plastic on river microbiome International conference
2019.03
Event date： 2019.03
Language：Japanese Presentation type：Oral presentation (general)
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Effects of bacterial community in the river water by degradation of bioplastic International conference
2019.03
Event date： 2019.03
Language：Japanese Presentation type：Oral presentation (general)
Committee Memberships 【 display / non-display 】
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日本微生物資源学会 理事（会計）
2014.09
Committee type：Academic society
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日本微生物資源学会 理事（編集副委員長）
2009.04 - 2014.08
Committee type：Academic society
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日本微生物系統分類研究会 理事（会計）
2008.01 - 2015.03