|
Title |
Professor |
|
External Link |
|
|
|
TAKAHASHI Kosaku Professor |
From Graduate School 【 display / non-display 】
-
Hokkaido University Graduate School, Division of Agriculture Master Course Completed
1991.04 - 1993.03
Country：Japan
Degree 【 display / non-display 】
-
博士（農学） ( 2002.03 北海道大学 )
-
修士（農学） ( 1993.03 北海道大学 )
Employment Record in Research 【 display / non-display 】
-
Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Nutritional Science Professor
2019.04
Professional Memberships 【 display / non-display 】
-
日本健康医学会
2022.08
-
Japanese Society of Food Hygiene and Saefty
2019.08
-
植物化学調節学会
2009.08
-
日本農芸化学会
1997.11
Qualification and License 【 display / non-display 】
-
First Kind of High School Teacher License
-
Health Supervisor (first kind)
Papers 【 display / non-display 】
-
Noe Mitsui, Kouji Shiono, Yoshiya Seto, Tadasu Furusho, Chika Saito, Kosaku Takahashi
Foods 15 ( 1 ) 92 2025.12
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Multidisciplinary Digital Publishing Institute
Dipeptidyl peptidase-4 (DPP-4) is a protease that degrades incretin and inhibits the secretion of insulin. Consequently, DPP-4 inhibition promotes insulin secretion and prevents the onset of type 2 diabetes. Given the growing interest in food-derived DPP-4 inhibitory peptides as potential functional ingredients, buckwheat (Fagopyrum esculentum) represents a promising source; however, few studies have investigated the bioactivity of peptides derived from buckwheat flour hydrolysates. In this study, two DPP-4 inhibitory peptides, Ile-Pro-Trp and Ile-Pro-Leu, were identified through purification of buckwheat flour hydrolysate and liquid chromatography–tandem mass spectrometry analysis. In a rat oral glucose tolerance test (OGTT), a fraction of buckwheat flour hydrolysate, crudely purified by reverse-phase column chromatography, showed a non-significant trend toward reducing increases in blood glucose. To our knowledge, this study is the first to show that Ile-Pro-Trp isolated from food protein hydrolysates exhibits considerable DPP-4 inhibitory activity. Moreover, this is the first study identifying Ile-Pro-Ile as a DPP-4 inhibitor from a plant source.
-
Isolation and Structure Determination of cis-OPDA-α-Monoglyceride from Arabidopsis thaliana. Reviewed
Shotaro Hirota, Yusuke Ito, Shiro Inoue, Naoki Kitaoka,Tohru Taniguchi, Kenji Monde, Kosaku Takahashi, Hideyuki Matsuura
Journal of Natural Products 87 ( 5 ) 1358 - 1367 2024.04
Language：English Publishing type：Research paper (scientific journal) Publisher：American Chemical Society
cis-12-oxo-Phytodieneoic acid-α-monoglyceride (1) was isolated from Arabidopsis thaliana. The chemical structure of 1 was elucidated based on exhaustive 1D and 2D NMR spectroscopic measurements and supported by FDMS and HRFDMS data. The absolute configuration of the cis-OPDA moiety in 1 was determined by comparison of 1H NMR spectra and ECD measurements. With respect to the absolute configuration of the β-position of the glycerol backbone, the 2:3 ratio of (S) to (R) was determined by making ester-bonded derivatives with (R)-(+)-α-methoxy-α-trifluoromethylphenylacetyl chloride and comparing 1H NMR spectra. Wounding stress did not increase endogenous levels of 1, and it was revealed 1 had an inhibitory effect of A. thaliana post germination growth. Notably, the endogenous amount of 1 was higher than the amounts of (+)-7-iso-jasmonic acid and (+)-cis-OPDA in intact plants. 1 also showed antimicrobial activity against Gram-positive bacteria, but jasmonic acid did not. It was also found that α-linolenic acid-α-monoglyceride was converted into 1 in the A. thaliana plant, which implied α-linolenic acid-α-monoglyceride was a biosynthetic intermediate of 1.
-
Abscisic acid-mediated sugar responses are essential for vegetative desiccation tolerance in the liverwort Marchantia polymorpha
Physiologia Plantarum 2023.03
-
INOUE Hirofumi, SHIONO Kouji, TAKAHASHI Kosaku, MORIMOTO Hiromu, TAKAHASHI Nobuyuki, UEHARA Mariko
Food Preservation Science 49 ( 5 ) 255 - 261 2023
Language：Japanese Publisher：Japan Association of Food Preservation Scientists
<p> Periodontal disease is a major public health problem that affects over half of the adult population worldwide. Lipopolysaccharides (LPS), produced by the periodontopathic bacterium <i>Porphyromonas gingivalis</i>, induces the expression of inflammatory cytokines that promote inflammatory bone destruction. Buckwheat bran (BB), a traditional pseudocereal crop, belongs to a group of grains having high nutritional value and has been reported to be an effective agent. However, the anti-inflammatory effects of BB on <i>Porphyromonas gingivalis</i>-lipopolysaccharide (<i>P.g</i>.-LPS) -stimulated human gingival fibroblasts (HGFs) have not been completely elucidated yet. This study determined that the buckwheat bran flour hydrolysate powder (BBFHP) significantly inhibited the <i>P.g</i>.-LPS-induced production of inflammation-associated genes, including interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and Toll-like receptor 4 (TLR4). Moreover, BBFHP suppressed <i>P.g</i>.-LPS-induced NF-κB signaling. The results suggest that the BBFHP attenuates the production of inflammation-associated molecules and suppresses the activation of NF-κB in <i>P.g</i>.-LPS treated HGFs.</p>
DOI： 10.5891/jafps.49.255
-
ソバペプチドはDPP-IV活性を阻害する
2022.12
Misc 【 display / non-display 】
-
光親和性標識基を用いない新規な標的タンパク質検出法 Invited
穴吹友亮、高橋公咲
アグリバイオ 2019.04
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
Honours, Awards and Prizes 【 display / non-display 】
-
日本農芸化学会北海道支部奨励賞
2011.11
Award type：International academic award (Japan or overseas) Country：Japan
Presentations 【 display / non-display 】
-
2-Methyl-2-butene contributes to generate（Z） olefin in dihydrogenation of alkynes to alkenes using Lindlar's catalyst International conference
Vera Fitriya Ersalena，Kanji Miyawaki，Kosaku Takahashi，Hideyuki Matsuura
日本農芸化学会2019年度大会 2019.03 日本農芸化学会
Event date： 2019.03
Language：English Presentation type：Oral presentation (general)
Venue：東京農業大学
-
Evaluation of positive feedback system for jasmonic acid biosynthesis using deuterium-labelled jasmonic acid International conference
Rishni Masimbula，Katsunari Oki，Norio Kondo，Hideyuki Matsuura，Kosaku Takahashi
日本農芸化学会2019年度大会 2019.03 日本農芸化学会
Event date： 2019.03
Language：English Presentation type：Oral presentation (general)
Venue：東京農業大学
-
新規なリンカーとタンパク質架橋剤を用いる生理活性化合物の標的タンパク質精製法 International conference
穴吹 友亮、伊藤 祐輔、塚原 美宙、高須賀 太一、岡本 昌憲、松浦 英幸、高橋 公咲
日本農芸化学会2019年度大会 2019.03 日本農芸化学会
Event date： 2019.03
Language：Japanese Presentation type：Oral presentation (general)
Venue：東京農業大学
-
植物の抽苔抑制化合物の構造活性相関研究 International conference
志鎌 駿平、荻原 毅、松浦 英幸、高橋 公咲
日本農芸化学会2019年度大会 2019.03 日本農芸化学会
Event date： 2019.03
Language：Japanese Presentation type：Oral presentation (general)
Venue：東京農業大学
-
シロバナムシヨケギクにおけるピレスリンの生合成研究 International conference
滝口 輝澄、松井 稜、大木 克成、天野 就基、高橋 公咲、阪森 宏治、松田 一彦、松浦 英幸
植物化学調節学会第53回大会研究発表記録集 2018.11 植物化学調節学会
Event date： 2018.11
Language：Japanese Presentation type：Oral presentation (general)
Venue：北海道大学
Committee Memberships 【 display / non-display 】
-
植物化学調節学会 編集委員
2018.11 - 2020.10
Committee type：Academic society