Papers - TAKAHASHI Nobuyuki
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"Piceatannol promotes the osteogenic differentiation of human periodontal ligament cells through MAPKs activation" Reviewed International journal
Morimoto H, Inoue H, Date K, Kawakami S, Mori S, Maruki-Uchida H, Takahashi N, Uehara M
Bioscience Biotechnology and Biochemistry in press 2025.05
Language：English Publishing type：Research paper (scientific journal)
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"Myricetin and myricitrin indirectly and directly increases uncoupling protein-1 mRNA expression in C3H10T1/2 beige adipocytes." Reviewed International journal
Takahashi H, Morimoto H, Tanaka M, Inoue H, Goto T, Kawada T, Uehara M, Takahashi N* (* corresponding author)
Biochemistry and Biophysics Research Communication 734 150771 2024.11
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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"A modified system using macrophage-conditioned medium revealed that the indirect effects of anti-inflammatory food-derived compounds improve inflammation-induced suppression of UCP-1 mRNA expression in 10T1/2 adipocytes" Reviewed International journal
Takahashi H, Morikawa M, Ozaki E, Numasaki M, Morimoto H, Tanaka M, Inoue H, Goto T, Kawada T, Eguchi F, Uehara M, Takahashi N* (* corresponding author)
Bioscience Biotechnology and Biochemistry 80 679 - 688 2024.03
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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"Release of SMP30 in extracellular vesicles under conditions of ascorbic acid deficiency is involved with acute phase response in ODS rat." Reviewed International journal
Arakawa K, Inoue H, Ishigami, A, Sato A, Takino Y, Tanaka M, Morimoto H, Takahashi N, Uehara M.
Journal of Nutritional Science and Vitaminology 69 ( 6 ) 420 - 427 2023.12
Language：English Publishing type：Research paper (scientific journal)
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"Resveratrol Upregulates Senescence Marker Protein 30 by Activating AMPK/Sirt1-Foxo1 Signals and Attenuating H2O2-Induced Damage in FAO Rat Liver Cells." Reviewed International journal
Inoue H, Shimizu Y, Yoshikawa H, Arakawa K, Tanaka M, Morimoto H, Sato A, Takino Y, Ishigami A, Takahashi N, Uehara M
Journal of Nutritional Science and Vitaminology 69 ( 5 ) 388 - 393 2023.10
Language：English Publishing type：Research paper (scientific journal) Publisher：一般財団法人 学会誌刊行センター
DOI： 10.3177/jnsv.69.388
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"AMPK negatively regulates RANKL-induced osteoclast differentiation by controlling oxidative stress" Reviewed International journal
Tanaka M, Inoue H, Takahashi N, Uehara M.
Free Radical Biology and Medicine 205 107 - 115 2023.08
Language：English Publishing type：Research paper (scientific journal)
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"Educational material research on the color of Crayfish for conversion to edible recourses." Reviewed International journal
Higuchi S, Ono H, Honda H, Maskey S, Kurosawa A, Suzuki T, Takahashi N, Okazawa H, Takeda K.
International Journal of Environmental and Rural Development 14 ( 1 ) 98 - 105 2023.02
Language：English Publishing type：Research paper (scientific journal)
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"(S)-Equol is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency-Induced Bone Loss in Mice" Reviewed International journal
Tanaka M, Fujii S, Inoue H, Takahashi N, Ishimi Y, Uehara M.
Journal of Nutrition 152 ( 8 ) 1831 - 1842 2022.08
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1093/jn/nxac130
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"Erucin inhibits osteoclast formation via suppressing cell-cell fusion molecule DC-STAMP without influencing mineralization by osteoblasts." Reviewed International journal
Takagi T, Inoue H, Fujii S, Takahashi N, Uehara M.
BMC Res. Notes 15 ( 1 ) 105 2022.03
Language：English Publishing type：Research paper (scientific journal)
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"Upregulation and stabilization of senescence marker protein-30 by epigallocatechin gallate agaist tert-butyl hydroperoxide-induced liver injury in vitro and in vivo." Reviewed International journal
Inoue H, Arakawa K, Tanaka M, Katsumata-Tsuboi R, Takahashi N, Uehara M.
Journal of Clinical Biochemistry and Nutrition 68 ( 1 ) 51 - 57 2021.01
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3164/jcbn.20-119
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"Iron deficiency negatively regulates protein methylation via the downregulation of protein arginine methyltransferase." Reviewed International journal
Inoue H, Tanaka M, Takahashi N, Uehara M.
Heliyon 6 e05059 2020.10
Language：English Publishing type：Research paper (scientific journal)
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"Food-derived compounds apigenin and luteolin modulate mRNA splicing of introns with weak splice sites." Reviewed International journal
Kurata M, Fujiwara N, Fujita K, Yamanaka Y, Seno S, Kobayashi H, Miyamae Y, Takahashi N, Shibuya Y, Masuda S.
iScience 22 336 - 352 2019.11
Language：English Publishing type：Research paper (scientific journal)
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"beta-Cryptoxanthin induces UCP-1 expression via a RXR pathway in adipose tissue." Reviewed International journal
Hara H, Takahashi H, Mohri S, Murakami H, Kawarasaki S, Iwase M, Takahashi N, Sugiura M, Goto T, Kawada T.
Journal of Agriculture and Food Chemistry 67 10595 - 10603 2019.09
Language：English Publishing type：Research paper (scientific journal)
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"A new mouse model for noninvasive fluorescence-based UCP1 expression monitoring." Reviewed International coauthorship International journal
Kawarasaki S, Kuwata H, Sawazaki H, Sakamoto T, Nitta T, Kim CS, Jheng HF, Takahashi H, Nomura W, Ara T, Takahashi N, Tomita K Yu R, Kawada T, Goto T.
FEBS Letters 593 1201 - 1212 2019.06
Language：English Publishing type：Research paper (scientific journal)
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"The DPP-4 inhibitor, teneligliptin enhances brown adipose tissue function, leading to the prevention of obesity in mice." Reviewed International journal
Takeda K, Sawazaki H, Takahashi H, Yeh YS, Jheng HF, Nomura W, Ara T, Takahashi N, Seno S, Osato N, Matsuda H, Kawada T, Goto T.
FEBS Open Bio 8 1782 - 1793 2018.11
Language：English Publishing type：Research paper (scientific journal)
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"Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence." Reviewed International journal
Inoue H, Hanawa N, Katsumata-Tsuboi R, Katsumata SI, Takahashi N, Uehara M.
Bioscience Biotechnology and Biochemistry 82 ( 5 ) 900 - 903 2018.05
Language：English Publishing type：Research paper (scientific journal)
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"A phytol-enriched diet activates PPAR-alpha in the liver and brown adipose tissue to ameliorate obesity-Induced metabolic abnormalities." Reviewed International journal
An JY, Jheng HF, Nagai H, Sanada K, Takahashi H, Iwase M, Watanabe N, Kim YI, Teraminami A, Takahashi N, Nakata R, Inoue H, Seno S, Mastuda H, Kawada T, Goto T.
Molecular Nutrition and Food Research 62 ( 6 ) e1700688 2018.03
Language：English Publishing type：Research paper (scientific journal)
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"Alpha-linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40." Reviewed International journal
Ohue-Kitano R, Yasuoka Y, Goto T, Kitamura N, Park SB, Kishino S, Kimura I, Kasubuchi M, Takahashi H, Li Y, Yeh YS, Jheng HF, Iwase M, Tanaka M, Masuda S, Inoue T, Yamakage H, Kusakabe T, Tani F, Shimatsu A, Takahashi N, Ogawa J, Satoh-Asahara N, Kawada T.
FASEB Journal 32 304 - 318 2018.01
Language：English Publishing type：Research paper (scientific journal)
乳酸菌がα-リノレン酸を原料に作り出す代謝産物が、脂肪酸受容体の一つであるGPR40の活性化を介して、抗炎症作用を持つM2マクロファージの分化を促進させることを明らかにした論文。
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"10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1." Reviewed International coauthorship International journal
Kim M, Furuzono T, Yamakuni K, Li Y, Kim YI, Takahashi H, Ohue-Kitano R, Jheng HF, Takahashi N, Kano Y, Yu R, Kishino S, Ogawa J, Uchida K, Yamazaki J, Tominaga M, Kawada T, Goto T.
FASEB Journal 31 5036 - 5048 2017.11
Language：English Publishing type：Research paper (scientific journal)
腸内細菌である乳酸菌によるリノール酸代謝産物が、イオンチャネルであるTRPV1を活性化することで、褐色脂肪細胞を活性化し、エネルギー代謝を更新させることを示した論文。
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"L-Ornithine and L-lysine stimulate gastrointestinal motility via TRPV1." Reviewed International journal
Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K.
Molecular Nutrition and Food Research 61 ( 11 ) e1700230 2017.11
Language：English Publishing type：Research paper (scientific journal)
L-オルニチンとL-リジンが、イオンチャネルであるTRPV1を活性化することで、消化管の蠕動運動を刺激することを示した論文。