Papers - TAKAHASHI Nobuyuki
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"Piceatannol promotes the osteogenic differentiation of human periodontal ligament cells through MAPKs activation" Reviewed International journal
Morimoto H, Inoue H, Date K, Kawakami S, Mori S, Maruki-Uchida H, Takahashi N, Uehara M
Bioscience Biotechnology and Biochemistry in press 2025.05
Language：English Publishing type：Research paper (scientific journal)
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"Myricetin and myricitrin indirectly and directly increases uncoupling protein-1 mRNA expression in C3H10T1/2 beige adipocytes." Reviewed International journal
Takahashi H, Morimoto H, Tanaka M, Inoue H, Goto T, Kawada T, Uehara M, Takahashi N* (* corresponding author)
Biochemistry and Biophysics Research Communication 734 150771 2024.11
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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"A modified system using macrophage-conditioned medium revealed that the indirect effects of anti-inflammatory food-derived compounds improve inflammation-induced suppression of UCP-1 mRNA expression in 10T1/2 adipocytes" Reviewed International journal
Takahashi H, Morikawa M, Ozaki E, Numasaki M, Morimoto H, Tanaka M, Inoue H, Goto T, Kawada T, Eguchi F, Uehara M, Takahashi N* (* corresponding author)
Bioscience Biotechnology and Biochemistry 80 679 - 688 2024.03
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Takahashi Nobuyuki, Takahashi Hisako, Morimoto Hiromu, Inoue Hirofumi, Goto Tsuyoshi, Kawada Teruo, Uehara Mariko
Nippon Eiyo Shokuryo Gakkaishi 77 ( 2 ) 109 - 115 2024
Language：Japanese Publisher：Japan Society of Nutrition and Food Science
<p>Chronic inflammation in white adipose tissue associated with obesity has been shown to cause insulin resistance leading to diabetes. Recently, it has also become clear that chronic inflammation may exacerbate obesity by inhibiting the heat-producing capacity of brown and beige adipocytes, which are able to convert the energy obtained from fat consumption into heat. It has also been suggested that chronic inflammation in the intestinal tract may exacerbate postprandial hyperlipidemia, a risk factor for the development of atherosclerotic diseases. Thus, chronic inflammation <i>in vivo</i> causes abnormal lipid metabolism and is involved in the development of various lifestyle-related diseases. This implies that daily dietary intake of food-derived compounds with anti-inflammatory effects that suppress this chronic inflammation can be expected to improve abnormalities in lipid metabolism. In this article, we review the mechanism of lipid metabolism abnormalities caused by chronic inflammation and the effects of anti-inflammatory food components on lipid metabolism.</p>
DOI： 10.4327/jsnfs.77.109
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Tanaka Miori, Iida Kaoruko, Inoue Hirofumi, Takahashi Nobuyuki, Uehara Mariko
Nippon Eiyo Shokuryo Gakkaishi 77 ( 2 ) 117 - 124 2024
Language：Japanese Publisher：Japan Society of Nutrition and Food Science
<p>Chronic inflammation is an initial pathology common to lifestyle-related diseases, atherosclerosis, and bone diseases. In the adipose tissue of obese individuals, macrophages infiltrate hypertrophic adipocytes, resulting in excessive secretion of free fatty acids from adipocytes and inflammatory cytokines from macrophages. The paracrine interaction between adipocytes and macrophages contributes to chronic inflammation and fibrosis of adipose tissue, thereby inducing ectopic lipid accumulation in other organs and metabolic disorders such as insulin resistance. In addition, chronic inflammation leads to disruption of bone metabolism and increased bone resorption, in turn causing various bone diseases. On the other hand, polyphenols have been reported to exert an anti-inflammatory effect and are expected to contribute to disease prevention. This review outlines the role of chronic inflammation in the development and progression of various inflammatory diseases related to metabolic syndrome and locomotive syndrome and introduces the disease-preventive effects of polyphenols targeting chronic inflammation.</p>
DOI： 10.4327/jsnfs.77.117
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"Release of SMP30 in extracellular vesicles under conditions of ascorbic acid deficiency is involved with acute phase response in ODS rat." Reviewed International journal
Arakawa K, Inoue H, Ishigami, A, Sato A, Takino Y, Tanaka M, Morimoto H, Takahashi N, Uehara M.
Journal of Nutritional Science and Vitaminology 69 ( 6 ) 420 - 427 2023.12
Language：English Publishing type：Research paper (scientific journal)
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"Resveratrol Upregulates Senescence Marker Protein 30 by Activating AMPK/Sirt1-Foxo1 Signals and Attenuating H2O2-Induced Damage in FAO Rat Liver Cells." Reviewed International journal
Inoue H, Shimizu Y, Yoshikawa H, Arakawa K, Tanaka M, Morimoto H, Sato A, Takino Y, Ishigami A, Takahashi N, Uehara M
Journal of Nutritional Science and Vitaminology 69 ( 5 ) 388 - 393 2023.10
Language：English Publishing type：Research paper (scientific journal) Publisher：一般財団法人 学会誌刊行センター
DOI： 10.3177/jnsv.69.388
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"AMPK negatively regulates RANKL-induced osteoclast differentiation by controlling oxidative stress" Reviewed International journal
Tanaka M, Inoue H, Takahashi N, Uehara M.
Free Radical Biology and Medicine 205 107 - 115 2023.08
Language：English Publishing type：Research paper (scientific journal)
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"Educational material research on the color of Crayfish for conversion to edible recourses." Reviewed International journal
Higuchi S, Ono H, Honda H, Maskey S, Kurosawa A, Suzuki T, Takahashi N, Okazawa H, Takeda K.
International Journal of Environmental and Rural Development 14 ( 1 ) 98 - 105 2023.02
Language：English Publishing type：Research paper (scientific journal)
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INOUE Hirofumi, SHIONO Kouji, TAKAHASHI Kosaku, MORIMOTO Hiromu, TAKAHASHI Nobuyuki, UEHARA Mariko
Food Preservation Science 49 ( 5 ) 255 - 261 2023
Language：Japanese Publisher：Japan Association of Food Preservation Scientists
<p> Periodontal disease is a major public health problem that affects over half of the adult population worldwide. Lipopolysaccharides (LPS), produced by the periodontopathic bacterium <i>Porphyromonas gingivalis</i>, induces the expression of inflammatory cytokines that promote inflammatory bone destruction. Buckwheat bran (BB), a traditional pseudocereal crop, belongs to a group of grains having high nutritional value and has been reported to be an effective agent. However, the anti-inflammatory effects of BB on <i>Porphyromonas gingivalis</i>-lipopolysaccharide (<i>P.g</i>.-LPS) -stimulated human gingival fibroblasts (HGFs) have not been completely elucidated yet. This study determined that the buckwheat bran flour hydrolysate powder (BBFHP) significantly inhibited the <i>P.g</i>.-LPS-induced production of inflammation-associated genes, including interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and Toll-like receptor 4 (TLR4). Moreover, BBFHP suppressed <i>P.g</i>.-LPS-induced NF-κB signaling. The results suggest that the BBFHP attenuates the production of inflammation-associated molecules and suppresses the activation of NF-κB in <i>P.g</i>.-LPS treated HGFs.</p>
DOI： 10.5891/jafps.49.255
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"(S)-Equol is More Effective than (R)-Equol in Inhibiting Osteoclast Formation and Enhancing Osteoclast Apoptosis, and Reduces Estrogen Deficiency-Induced Bone Loss in Mice" Reviewed International journal
Tanaka M, Fujii S, Inoue H, Takahashi N, Ishimi Y, Uehara M.
Journal of Nutrition 152 ( 8 ) 1831 - 1842 2022.08
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1093/jn/nxac130
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"Erucin inhibits osteoclast formation via suppressing cell-cell fusion molecule DC-STAMP without influencing mineralization by osteoblasts." Reviewed International journal
Takagi T, Inoue H, Fujii S, Takahashi N, Uehara M.
BMC Res. Notes 15 ( 1 ) 105 2022.03
Language：English Publishing type：Research paper (scientific journal)
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"Upregulation and stabilization of senescence marker protein-30 by epigallocatechin gallate agaist tert-butyl hydroperoxide-induced liver injury in vitro and in vivo." Reviewed International journal
Inoue H, Arakawa K, Tanaka M, Katsumata-Tsuboi R, Takahashi N, Uehara M.
Journal of Clinical Biochemistry and Nutrition 68 ( 1 ) 51 - 57 2021.01
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3164/jcbn.20-119
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"Iron deficiency negatively regulates protein methylation via the downregulation of protein arginine methyltransferase." Reviewed International journal
Inoue H, Tanaka M, Takahashi N, Uehara M.
Heliyon 6 e05059 2020.10
Language：English Publishing type：Research paper (scientific journal)
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"Food-derived compounds apigenin and luteolin modulate mRNA splicing of introns with weak splice sites." Reviewed International journal
Kurata M, Fujiwara N, Fujita K, Yamanaka Y, Seno S, Kobayashi H, Miyamae Y, Takahashi N, Shibuya Y, Masuda S.
iScience 22 336 - 352 2019.11
Language：English Publishing type：Research paper (scientific journal)
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"beta-Cryptoxanthin induces UCP-1 expression via a RXR pathway in adipose tissue." Reviewed International journal
Hara H, Takahashi H, Mohri S, Murakami H, Kawarasaki S, Iwase M, Takahashi N, Sugiura M, Goto T, Kawada T.
Journal of Agriculture and Food Chemistry 67 10595 - 10603 2019.09
Language：English Publishing type：Research paper (scientific journal)
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"A new mouse model for noninvasive fluorescence-based UCP1 expression monitoring." Reviewed International coauthorship International journal
Kawarasaki S, Kuwata H, Sawazaki H, Sakamoto T, Nitta T, Kim CS, Jheng HF, Takahashi H, Nomura W, Ara T, Takahashi N, Tomita K Yu R, Kawada T, Goto T.
FEBS Letters 593 1201 - 1212 2019.06
Language：English Publishing type：Research paper (scientific journal)
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"The DPP-4 inhibitor, teneligliptin enhances brown adipose tissue function, leading to the prevention of obesity in mice." Reviewed International journal
Takeda K, Sawazaki H, Takahashi H, Yeh YS, Jheng HF, Nomura W, Ara T, Takahashi N, Seno S, Osato N, Matsuda H, Kawada T, Goto T.
FEBS Open Bio 8 1782 - 1793 2018.11
Language：English Publishing type：Research paper (scientific journal)
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"Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence." Reviewed International journal
Inoue H, Hanawa N, Katsumata-Tsuboi R, Katsumata SI, Takahashi N, Uehara M.
Bioscience Biotechnology and Biochemistry 82 ( 5 ) 900 - 903 2018.05
Language：English Publishing type：Research paper (scientific journal)
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"A phytol-enriched diet activates PPAR-alpha in the liver and brown adipose tissue to ameliorate obesity-Induced metabolic abnormalities." Reviewed International journal
An JY, Jheng HF, Nagai H, Sanada K, Takahashi H, Iwase M, Watanabe N, Kim YI, Teraminami A, Takahashi N, Nakata R, Inoue H, Seno S, Mastuda H, Kawada T, Goto T.
Molecular Nutrition and Food Research 62 ( 6 ) e1700688 2018.03
Language：English Publishing type：Research paper (scientific journal)