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Associate Professor |
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KEMURIYAMA Noriko Associate Professor |
From School 【 display / non-display 】
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Tokyo University of Agriculture Graduated
- 2005.03
Country：Japan
From Graduate School 【 display / non-display 】
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Tokyo Medical and Dental University Doctor Course Completed
- 2011.03
Country：Japan
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Tokyo Medical and Dental University Master Course Completed
- 2007.03
Country：Japan
Degree 【 display / non-display 】
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博士（医学） ( 2011.03 東京医科歯科大学 )
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修士（医学） ( 2007.03 東京医科歯科大学 )
Employment Record in Research 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Nutritional Science and Food Safety Assistant Professor
2014.04 - 2022.03
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Nutritional Science and Food Safety Associate Professor
2022.04
External Career 【 display / non-display 】
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University of Tsukuba Postdoctoral Fellowships of Japan Society for the Promotion of Science
2011.04 - 2014.03
Country：Japan
Professional Memberships 【 display / non-display 】
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日本毒性学会
2015.04
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日本栄養・食糧学会
2015.04
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日本毒性病理学会
2014.01
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日本糖尿病学会
2013.04
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日本内分泌学会
2006.04
Research Areas 【 display / non-display 】
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Life Science / Experimental pathology
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Life Science / Metabolism and endocrinology
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Humanities & Social Sciences / Family and consumer sciences, and culture and living
Papers 【 display / non-display 】
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Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae
PLOS ONE 18 ( 8 ) e0287657 2023.08
Authorship：Corresponding author
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Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.
Keiichi Ohata, Takeshi Sugaya, Hanh Nhung Nguyen, Yuri Hatanaka, Kinuko Uno, Marika Tohma, Tsuyoshi Oikawa, Hiroshi Nagabukuro, Kanako Kuniyeda, Atsuko Kamijo-Ikemori, Noriko Suzuki-Kemuriyama, Dai Nakae, Eisei Noiri, Katsuhiro Miyajima
Nephrology (Carlton) ( 28 ) 345 - 355 2023.06
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Uno Kinuko, Miyajima Katsuhiro, Ogawa Shuji, Suzuki-Kemuriyama Noriko, Nakae Dai
Journal of Toxicologic Pathology 36 ( 1 ) 1 - 10 2023
Language：English Publisher：JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
<p><i>Siraitia grosvenorii</i> is the fruit of a cucurbitaceous vine endemic to China. Its extract has been used as a sweetener and exhibits various anti-inflammatory and anticarcinogenic effects mediated via its antioxidant properties. In the present study, we aimed to clarify the preventive or ameliorative effects of <i>S. grosvenorii</i> extract (SGE) on nonalcoholic steatohepatitis-like lesions induced in male Hsd: Sprague Dawley rats fed a choline-deficient, methionine-lowered, <span style="font-variant: small-caps;">l-</span>amino acid-defined diet for 13 weeks. This diet increased hepatotoxicity parameters and upregulated the expression of inflammation- and fibrosis-related genes in the liver, resulting in the progression of hepatic lesions, oxidative stress, hepatocellular apoptosis, and fibrosis. Furthermore, this diet upregulated the expression of phosphorylated nuclear factor-κB (NF-κB) and CD44. SGE administration inhibited these lesions, similar to CD44, a factor that controls hepatic inflammation and fibrosis. These results revealed that SGE impacts the disease stage via antioxidative effects and regulation of CD44 expression. SGE was found to be useful for preventing and treating steatohepatitis.</p>
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CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet.
Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae
Journal of Toxicologic Pathology 2022.04
Language：English Publishing type：Research paper (scientific journal)
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Influence of trans-fatty acids on non-alcoholic steatohepatitis with hepatic fibrosis induced by a choline-deficient, methionine-lowered, L-amino acid-defined diet in male Harlan Sprague Dawley rats.
Kinuko Uno, Katsuhiro Miyajima, Marika Matsumoto, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae
Fundamental Toxicological Sciences 8 ( 7 ) 221 - 228 2021.12
Language：English Publishing type：Research paper (scientific journal)
Books and Other Publications 【 display / non-display 】
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糖尿病の分子標的と治療薬事典
煙山紀子、矢作直也（ Role： Joint author , GPR120について）
羊土社 2013.03
Language：Japanese Book type：Scholarly book
糖尿病・代謝性疾患治療の標的となる分子および分子標的治療薬について、分子の生理作用や疾患とのかかわりなどの基礎的な知見から効果や適応などを紹介
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慢性炎症と生活習慣病
煙山（鈴木）紀子、松坂賢、島野仁（ Role： Joint author）
南山堂 2013.02
Language：Japanese Book type：Scholarly book
１８章 慢性炎症と栄養：生活習慣病やがんをはじめとする様々な疾患の基盤病態として慢性炎症が注目されているが、本章では、栄養に焦点をあてて、慢性炎症の分子機構に関する最新の知見を紹介した。
Honours, Awards and Prizes 【 display / non-display 】
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第76回日本栄養・食糧学会大会トピックス賞
2022.06
煙山 紀子，政所陽菜，渡邉颯人，中根冴，桐ケ窪彩，佐々木夏純，田中大揮，吉瀬優，美谷島克宏，中江大
Award type：International academic award (Japan or overseas) Country：Japan
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第24・25回日本病態栄養学会年次学術集会 若手研究特別賞
2022.01
煙山 紀子、阿部 有加里、結城 恵美、宇野絹子、中根冴、美谷島克宏、中江大
Award type：International academic award (Japan or overseas) Country：Japan
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第38回日本毒性病理学会総会及び学術集会 第1回アジア毒性病理学連盟学術集会 合同開催 「AUTP Student Award」
2022.01
中根冴、煙山紀子、阿部有加里、渡邉颯人、結城恵美、美谷島克宏、梅村隆志、中江大
Award type：International academic award (Japan or overseas) Country：Japan
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第75回日本栄養・食糧学会大会 トピックス賞
2021.07
煙山 紀子、阿部 有加里、結城 恵美、宇野絹子、中根冴、渡邊厚、美谷島克宏、中江大
Award type：International academic award (Japan or overseas) Country：Japan
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第35回日本毒性病理学会学術集会 優秀賞
2019.01
高臨風、煙山紀子、斎藤奈津美、渡邊聖栄子、龍完次郎、宇野絹子、張舜恵、小川秀治、渡邊厚、美谷島克宏、中江大
Award type：International academic award (Japan or overseas) Country：Japan
Scientific Research Funds Acquisition Results 【 display / non-display 】
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脂質代謝の観点から見た、IL-21シグナル制御と生活習慣病進展の関係
2023 - 2026
科学研究費補助金 基盤研究（C）
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脂質エネルギー代謝転写因子SREBPの免疫系干渉を介した生活習慣病制御機構の解明
2019.04 - 2021.03
科学研究費補助金 若手研究
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転写因子SREBP－１のNASHに対する病態生理的意義解明と新規食事治療法開発
2015.04 - 2019.03
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
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脂肪酸の質的特性とその代謝制御機構の解明
2011.04 - 2014.03
科学研究費補助金 特別研究員推奨費
Authorship：Principal investigator
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生理活性ペプチドホルモンによる摂食・代謝制御機構の解明
2009.04 - 2011.03
科学研究費補助金 特別研究員推奨費
Authorship：Principal investigator
Other External Funds 【 display / non-display 】
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生活習慣病の分子標的制御に資する甘味料の効果とその背景機構に関する研究
2016.04 - 2019.03
民間財団等
Authorship：Principal investigator Grant type：Competitive
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Elovl6KOマウスの摂食行動を解析し、摂食調節機構におけるElovl6を介した脂肪酸組成変化の意義を明らかにする
2014.04 - 2015.03
民間財団等 ２１世紀ＣＯＥプログラム
Authorship：Principal investigator Grant type：Competitive