研究者詳細 - 梶川　揚申

論文 - 梶川　揚申

分割表示 41 件中 1 - 20 件目／全件表示 >>

Harnessing flagellin of Ligilactobacillus agilis as a surface display scaffold for an HIV-1 epitope 査読あり国際共著国際誌

Shunya Suzuki, Gregg A. Dean, Akinobu Kajikawa

Applied and Environmental Microbiology 2025年05月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Society for Microbiology

DOI： https://doi.org/10.1128/aem.00674-25

Negative chemotaxis of Ligilactobacillus agilis BKN88 against gut-derived substances 査読あり国際誌

Shunya Suzuki, Kenji Yokota, Shizunobu Igimi & Akinobu Kajikawa

Scientific Reports 13 ( 1 ) 15632 2023年09月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Nature Limited.

DOI： 10.1038/s41598-023-42840-5.

その他リンク： https://www.nature.com/articles/s41598-023-42840-5

Immunogenic Modification of Ligilactobacillus agilis by Specific Amino Acid Substitution of Flagellin 査読あり

Akinobu Kajikawa, Naoto Eguchi, Shunya Suzuki

Applied and Environmental Microbiology 2022年09月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： https://doi.org/10.1128/aem.01277-22

Comparative analysis of immunological properties of S-layer proteins isolated from Lactobacillus strains. 査読あり

Suzuki S, Yokota K, Igimi S, Kajikawa A

Microbiology 165 ( 2 ) 188 - 196 2019年01月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1099/mic.0.000766

Mucosal Immunogenicity of Genetically Modified Lactobacillus acidophilus Expressing an HIV-1 Epitope within the Surface Layer Protein 査読あり

Akinobu Kajikawa, Lin Zhang, Alora LaVoy, Sara Bumgardner, Todd R. Klaenhammer, Gregg A. Dean

PLoS One 10 ( 10 ) e0141713 2015年10月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Lactobacillus acidophilusのS-layerタンパク質にヒト免疫不全ウィルス由来のエピトープを挿入し、その組換え体をマウスへ経口投与することで、粘膜局所および血中にエピトープ特異的抗体産生を誘導することに成功した。

DOI： 10.1371/journal.pone.0141713

その他リンク： http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141713

Characterization of the antifungal activity of the bacterial isolate Bacillus velezensis TCG15 査読あり国際誌

Kojiro Ito, Shun Tomita, Takahiro Fujimaki, Minenosuke Matsutani, Gen Enomoto, Akinobu Kajikawa, Kei Asai, Kenji Yokota

Archives of Microbiology 207 163 2025年05月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Nature

DOI： https://doi.org/10.1007/s00203-025-04357-5

Characterization of the NRPS operon homolog for surfactin A and surfactin C synthesis in Bacillus spp. 査読あり国際誌

Kojiro Ito, Mana Adachi, Minenosuke Matsutani, Ryota Kataoka, Gen Enomoto, Akinobu Kajikawa, Kenji Yokota

Archives of Microbiology 207 161 2025年05月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Nature

DOI： https://doi.org/10.1007/s00203-025-04341-z

Application of the SpCas9 inhibitor BRD0539 for CRISPR/Cas9-based genetic tools in Lacticaseibacillus paracasei 査読あり国際誌

TAMAKI Mizuna, CHIKU Tsutomu, SUZUKI Shunya, MISAKI Aya, FUNAKUBO Asuka, MATSUSHIMA Yoshitaka, YOKOTA Kenji, IGIMI Shizunobu, KAJIKAWA Akinobu

Bioscience of Microbiota, Food and Health 44 ( 1 ) 70 - 79 2025年

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMFH Press

Although the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas system has been extensively developed since its discovery for eukaryotic and prokaryotic genome editing and other genetic manipulations, there are still areas warranting improvement, especially regarding bacteria. In this study, BRD0539, a small-molecule inhibitor of Streptococcus pyogenes Cas9 (SpCas9), was used to suppress the activity of the nuclease during genetic modification of Lacticaseibacillus paracasei, as well as to regulate CRISPR interference (CRISPRi). First, we developed and validated a CRISPR-SpCas9 system targeting the sirA gene of L. paracasei. Then BRD0539 was used for CRISPR-dependent DNA cleavage in vivo. Our results suggested that the inhibitor worked partially in both Escherichia coli and L. paracasei. Next, we designed a CRISPRi system in a L. paracasei strain by inserting an inactive SpCas9 gene into the chromosome and introducing a plasmid encoding for a single guide RNA (sgRNA) targeting the sirA gene. Expression of sirA was successfully inhibited in the recombinant strains, and CRISPRi was abolished in an inhibitor-dependent manner. Our findings may help expand the CRISPR toolbox for research on lactic acid bacteria and other microbes.

DOI： 10.12938/bmfh.2024-009

Insights on suppression of bacterial leaf spot by Bacillus cyclic lipopeptides via induced resistance in Arabidopsis thaliana 査読あり

Carla Suzuki Altrão, Mana Kaneko, Shigeaki Shiina, Akinobu Kajikawa, Hirosuke Shinohara, Kenji Yokota

Journal of General Plant Pathology 88 259 - 263 2022年03月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s10327-022-01062-9

Insights into detoxification of tolaasins, the toxins behind mushroom bacterial blotch, by Microbacterium foliorum NBRC 103072T 査読あり

Shun Tomita, Akinobu Kajikawa, Shizunobu Igimi, Hirosuke Shinohara, Kenji Yokota

PhytoFrontiers 2021年03月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： doi.org/10.1094/PHYTOFR-10-20-0024-R

Ligilactobacillus agilis BKN88 possesses thermo-/acid- stable heteropolymeric flagellar filaments 査読あり

Naoto Eguchi, Shunya Suzuki, Kenji Yokota, Shizunobu Igimi and Akinobu Kajikawa

Microbiology 2021年01月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1099/mic.0.001020

PCR-based screening, isolation, and partial characterization of motile lactobacilli from various animal feces 査読あり

Shunya Suzuki, Koki Fujita, Shintaro Maeno, Yuh Shiwa, Akihito Endo, Kenji Yokota, Shizunobu Igimi and Akinobu Kajikawa

BMC Microbiology 20 142 2020年06月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1186/s12866-020-01830-7

Adsorption of tolaasins, the toxins behind mushroom bacterial blotch, by Microbacterium spp. is insufficient for its detoxification. 査読あり

Shun Tomita, Anna Hirayasu, Akinobu Kajikawa, Shizunobu Igimi, Hirosuke Shinohara, Kenji Yokota

Current Microbiology Epub 2020年01月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00284-020-01884-w

Pseudofructophilic Leuconostoc citreum Strain F192-5, Isolated from Satsuma Mandarin Peel 査読あり

Shintaro Maeno, Yasuhiro Tanizawa, Akinobu Kajikawa, Yu Kanesaki, Eri Kubota, Masanori Arita, Leon Dicks, Akihito Endo

Applied and Environmental Microbiology 85 ( 20 ) e01077-19 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1128/AEM.01077-19

Introduction of bifunctional alcohol/acetaldehyde dehydrogenase gene (adhE) in Fructobacillus fructosus settled its fructophilic characteristics 査読あり

Maeno S, Kajikawa A, Dicks L, Endo A.

Research in Microbiology 170 35 - 42 2019年02月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.resmic.2018.09.004.

The impact of motility on the localization of Lactobacillus agilis in the murine gastrointestinal tract. 査読あり

Kajikawa A, Suzuki S, Igimi S.

BMC Microbiol. 18 ( 1 ) 61 2018年07月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1186/s12866-018-1219-3.

Nod2 is required for antigen-specific humoral responses against antigens orally delivered using a recombinant Lactobacillus vaccine platform 査読あり

Sara A. Bumgardner, Lin Zhang, Alora S. LaVoy, Barbara Andre, Chad B. Frank, Akinobu Kajikawa, Todd R. Klaenhammer, Gregg A. Dean

PLoS One 13 ( 5 ) e0196950 2018年05月

記述言語：英語掲載種別：研究論文（学術雑誌）

Detoxification process of tolaasins, lipodepsipeptides, by Microbacterium sp. K3-5. 査読あり

Tomita S, Sue M, Kajikawa A, Igimi S, Shinohara H, Yokota K.

Biosci Biotechnol Biochem. online 2018年04月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1080/09168451.2018.1460575.

Intracellular localization of sirtuin and cell length analysis of Lactobacillus paracasei suggest possible role of sirtuin in cell division and cell shape regulation. 査読あり

Torres-Barredo GA, Atarashi H, Kajikawa A, Hirata A, Endo A, Nakagawa J.

Biosci Biotechnol Biochem. 82 ( 5 ) 916 - 925 2018年03月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1080/09168451.2018.1443790.

Induction of cellular immunity interleukin-12, antiproliferative effect, and related probiotic properties of lactic acid bacteria isolated in Thailand 査読あり

Tanatip Thamacharoensuk, Malai Taweechotipatr, Akinobu Kajikawa, Sanae Okada, and Somboon Tanasupawat

Annals of Microbiology 67 ( 8 ) 511 - 518 2017年08月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： https://doi.org/10.1007/s13213-017-1280-4

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