|
Title |
Assistant Professor |
|
External Link |
|
|
|
- Assistant Professor |
From School 【 display / non-display 】
-
Tokyo University of Agriculture Graduate School of Agriculture Applied Bioscience Graduated
2020.04 - 2022.03
Country：Japan
Notes：Department of Food and Nutritional Science
-
Tokyo University of Agriculture and Technology United Graduate School of Agricultural Science Department of Applied Life Science Graduated
2022.04
Country：Japan
Degree 【 display / non-display 】
-
Doctor of Agriculture ( 2025.03 Tokyo University of Agriculture and Technology )
Employment Record in Research 【 display / non-display 】
-
Tokyo University of Agriculture Faculty of International Agriculture and Food Studies Department of International Food and Agricultural Science Assistant Professor
2025.04
External Career 【 display / non-display 】
-
Tokyo University of Agriculture
2019.07 - 2020.03
Research Areas 【 display / non-display 】
-
Life Science / Food sciences
-
Life Science / Nutrition and health science
Research Interests 【 display / non-display 】
-
Nutritional science
-
Food science
-
gut microbiome
Papers 【 display / non-display 】
-
Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD. International journal
Shiro Otake, Shotaro Chubachi, Junki Miyamoto, Yuri Haneishi, Tetsuya Arai, Hideto Iizuka, Takashi Shimada, Kaori Sakurai, Shinichi Okuzumi, Hiroki Kabata, Takanori Asakura, Jun Miyata, Junichiro Irie, Koichiro Asano, Hidetoshi Nakamura, Ikuo Kimura, Koichi Fukunaga
Mucosal immunology 2024.12
Language：English Publishing type：Research paper (scientific journal)
We aimed to elucidate the dynamic changes in short-chain fatty acids (SCFA) produced by the gut microbiota following smoking exposure and their role in chronic obstructive pulmonary disease (COPD) pathogenesis. SCFA concentrations were measured in human plasma, comparing non-smokers (n = 6) and smokers (n = 12). Using a mouse COPD model induced by cigarette smoke exposure or elastase-induced emphysema, we modulated SCFA levels through dietary interventions and antibiotics to evaluate their effects on inflammation and alveolar destruction. Human smokers showed lower plasma SCFA concentrations than non-smokers, with plasma propionic acid positively correlating with forced expiratory volume in 1 s/forced vital capacity. Three-month smoking-exposed mice demonstrated altered gut microbiota and significantly reduced fecal SCFA concentrations compared to air-exposed controls. In these mice, a high-fiber diet increased fecal SCFAs and mitigated inflammation and alveolar destruction, while antibiotics decreased fecal SCFAs and exacerbated disease features. However, in the elastase-induced model, fecal SCFA concentration remained unchanged, and high-fiber diet or antibiotic interventions had no significant effect. These findings suggest that smoking exposure alters gut microbiota and SCFA production through its systemic effects. The anti-inflammatory properties of SCFAs may play a role in COPD pathogenesis, highlighting their potential as therapeutic targets.
-
The Intake of Dietary Lipids Improves Glucose Tolerance via Modulating Gut Microbiota
Yuri HANEISHI, Saya WATANABE, Ayana OKADA, Hitoshi TAKEMAE, Deborah BASTONI, Lucia TREPPICCIONE, Anella SAGGESE, Tetsuya MIZUTANI, Mauro ROSSI, Junki MIYAMOTO
Journal of Nutritional Science and Vitaminology 70 ( 4 ) 336 - 343 2024.08
Publishing type：Research paper (scientific journal) Publisher：Center for Academic Publications Japan
DOI： 10.3177/jnsv.70.336
-
Yuri Haneishi, Lucia Treppiccione, Francesco Maurano, Diomira Luongo, Junki Miyamoto, Mauro Rossi
Molecular Nutrition & Food Research 68 ( 9 ) 2024.04
Publishing type：Research paper (scientific journal) Publisher：Wiley
Abstract
The intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In celiac disease (CD), the serum phospholipid profile in infants who developed CD is dramatically different when compared to that of infants at risk of CD not developing the disease. In a mouse model of gluten sensitivity, oral wheat gliadin challenge in connection with inhibition of the metabolism of arachidonic acid, an omega‐6 polyunsaturated fatty acid, specifically induces the enteropathy. Recent evidence suggests that gluten may play a role also for development of life‐style related diseases in populations on a high fat diet (HFD). However, the mechanisms behind these effects are not yet understood. Exploratory studies in mice feed HFD show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota, and the immune cell profile in liver. -
Polyunsaturated fatty acids-rich dietary lipid prevents high fat diet-induced obesity in mice. International journal
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Hitoshi Takemae, Yuri Tanioka, Tetsuya Mizutani, Mauro Rossi, Junki Miyamoto
Scientific reports 13 ( 1 ) 5556 - 5556 2023.04
Language：English Publishing type：Research paper (scientific journal)
Diet is the primary factor affecting host nutrition and metabolism, with excess food intake, especially high-calorie diets, such as high-fat and high-sugar diets, causing an increased risk of obesity and related disorders. Obesity alters the gut microbial composition and reduces microbial diversity and causes changes in specific bacterial taxa. Dietary lipids can alter the gut microbial composition in obese mice. However, the regulation of gut microbiota and host energy homeostasis by different polyunsaturated fatty acids (PUFAs) in dietary lipids remains unknown. Here, we demonstrated that different PUFAs in dietary lipids improved host metabolism in high-fat diet (HFD)-induced obesity in mice. The intake of the different PUFA-enriched dietary lipids improved metabolism in HFD-induced obesity by regulating glucose tolerance and inhibiting colonic inflammation. Moreover, the gut microbial compositions were different among HFD and modified PUFA-enriched HFD-fed mice. Thus, we have identified a new mechanism underlying the function of different PUFAs in dietary lipids in regulating host energy homeostasis in obese conditions. Our findings shed light on the prevention and treatment of metabolic disorders by targeting the gut microbiota.
-
Inflammatory Bowel Diseases and Gut Microbiota. International journal
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
International journal of molecular sciences 24 ( 4 ) 2023.02
Language：English Publishing type：Research paper (scientific journal)
Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal tract, the incidence of which has rapidly increased worldwide, especially in developing and Western countries. Recent research has suggested that genetic factors, the environment, microbiota, and immune responses are involved in the pathogenesis; however, the underlying causes of IBD are unclear. Recently, gut microbiota dysbiosis, especially a decrease in the abundance and diversity of specific genera, has been suggested as a trigger for IBD-initiating events. Improving the gut microbiota and identifying the specific bacterial species in IBD are essential for understanding the pathogenesis and treatment of IBD and autoimmune diseases. Here, we review the different aspects of the role played by gut microbiota in the pathogenesis of IBD and provide a theoretical basis for modulating gut microbiota through probiotics, fecal microbiota transplantation, and microbial metabolites.
DOI： 10.3390/ijms24043817
Misc 【 display / non-display 】
-
Microbiomeと肥満症—Microbiome and obesity—今月の特集 マイクロバイオーム
羽石 悠里, 宮本 潤基, 木村 郁夫
臨床検査 = Journal of clinical laboratory medicine 66 ( 11 ) 1334 - 1339 2022.11
Language：Japanese Publisher：東京 : 医学書院
Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032450377
-
Tanioka, Y., Bito, T., Ishida, H., Haneishi, Y., Yamauchi, J., Furusho, T., Watanabe, F.
46 ( 4 ) 175 - 180 2020.09
Language：Japanese
Other Link： http://id.ndl.go.jp/bib/030705899
Scientific Research Funds Acquisition Results 【 display / non-display 】
-
腸内細菌叢を活性化する生活習慣病の予防・改善を目的とした新規機能性食品の開発
Grant number：23KJ0863 2023.04 - 2025.03
日本学術振興会 科学研究費助成事業 特別研究員奨励費 特別研究員奨励費
羽石 悠里
Grant amount：\1800000 （ Direct Cost: \1800000 ）