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職名 |
教授 |
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外部リンク |
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遠藤 明仁 (エンドウ アキヒト) ENDO Akihito 教授 |
学位 【 表示 ／ 非表示 】
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博士 （醸造学） （ 2005年03月 東京農業大学 ）
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修士 （農芸化学） （ 2002年03月 東京農業大学 ）
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学士 （農芸化学） （ 2000年03月 東京農業大学 ）
学内職務経歴 【 表示 ／ 非表示 】
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東京農業大学 生物産業学部 食品香粧学科 准教授
2013年09月 - 2018年03月
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東京農業大学 生物産業学部 食香粧化学科 准教授
2018年04月 - 2021年03月
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東京農業大学 生物産業学部 食香粧化学科 教授
2021年04月 - 2022年03月
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東京農業大学 応用生物科学部 食品安全健康学科 教授
2022年04月 - 現在
学外略歴 【 表示 ／ 非表示 】
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University of Turku, Finland Functional Foods Forum 研究員
2010年10月 - 2013年08月
国名：フィンランド共和国
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University of Stellenbosch, South Africa Department of Microbiology 研究員
2008年01月 - 2010年10月
国名：南アフリカ共和国
所属学協会 【 表示 ／ 非表示 】
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日本乳酸菌学会
2013年10月 - 現在
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腸内細菌学会
2015年04月 - 現在
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防菌防黴学会
2015年04月 - 現在
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国際細菌分類命名委員会内ビフィズス菌乳酸菌分類命名小委員会
2011年09月 - 現在
論文 【 表示 ／ 非表示 】
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KURAMITSU Kento, KADOTA Yoshihiro, WATANABE Ayako, ENDO Akihito, SHIMOMURA Yoshiharu, KITAURA Yasuyuki
Journal of Nutritional Science and Vitaminology 70 ( 4 ) 311 - 317 2024年08月
記述言語：英語 出版者・発行元：Center for Academic Publications Japan
<p>Chronic inflammation in adipose tissue is thought to contribute to insulin resistance, which involves the gut microbiota. Our previous studies have demonstrated that ingestion of 1-kestose can alter the gut microbiota composition, increase cecal butyrate levels, and improve insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Additionally, we found that 1-kestose supplementation ameliorated insulin resistance in obese rat models fed a high-fat diet (HFD), although the effects of 1-kestose on the abundance of inflammation-related gene in adipose tissue and gut microbiota composition in these rats were not explored. This study aimed to investigate the impact of 1-kestose on these parameters in HFD-fed rats, compared to OLETF rats. Male Sprague-Dawley rats were divided into two dietary groups, control or HFD, for 19 wk. Each group was further subdivided to receive either tap water or tap water supplemented with 2% (w/v) 1-kestose throughout the study. We evaluated gene expression in adipose tissue, as well as short-chain fatty acids (SCFAs) levels and microbial composition in the cecum contents. 1-Kestose intake restored the increased relative abundance of tumor necrosis factor (<i>Tnf</i>) mRNA in adipose tissue and the reduced level of butyrate in the cecum contents of HFD-fed rats to those observed in control diet-fed rats. Additionally, 1-kestose consumption changed the composition of the gut microbiota, increasing <i>Butyricicoccus</i> spp., decreasing UGC-005 and <i>Streptococcus</i> spp., in the cecum contents of HFD-fed rats. Our findings suggest that 1-kestose supplementation reduces adipose tissue inflammation and increases butyrate levels in the gut of HFD-fed rats, associated with changes in the gut microbiota composition, distinct from those seen in OLETF rats.</p>
DOI： 10.3177/jnsv.70.311
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Technique for assessing the astringency of persimmon fruit by measuring the liposome aggregation
Kera Kota, Makino Shohei, Takeda Risako, Shimeno Aoi, Hojo Masaya, Hamasaki Sadahiro, Endo Akihito, Iijima Masumi, Nakayama Tsutomu
Food Science and Technology Research 30 ( 2 ) 195 - 204 2024年
記述言語：英語 出版者・発行元：Japanese Society for Food Science and Technology
<p>The astringency of persimmon fruits is a significant factor for consumers and the nutritional industry. To date, astringents, such as polyphenols, specifically persimmon condensed tannins, have been assessed using polyphenol quantification assays, such as the Folin–Ciocalteu method, based on their reducing power. However, these methods are influenced by the presence of other reducing substances. In this study, we developed a cost-effective liposome turbidity analysis using a portable visible spectrophotometer based on the interaction between liposomes and astringents. Authentic astringents, such as catechins and theaflavin-3-<i>O</i>-gallate, were analyzed, and their half-maximal effective concentrations (EC<sub>50</sub>) were calculated. These results indicated that the affinity to the membrane was similar to that of astringency, as determined by sensory analysis. Additionally, the EC<sub>50</sub> values of partially purified tannins from non-astringent and astringent persimmons were calculated. In conclusion, we determined the application methods to assess astringent persimmon fruits with and without the removal of astringency.</p>
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Mitsuo Sakamoto, Naomi Sakurai, Hiroki Tanno, Takao Iino, Moriya Ohkuma, Akihito Endo
International Journal of Systematic and Evolutionary Microbiology 73 ( 8 ) 2023年08月
出版者・発行元：Microbiology Society
<jats:p>A strain of the recently validated species <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42294" xlink:type="simple">Faecalibacterium hominis</jats:ext-link>
</jats:named-content>
</jats:italic> shares 99.0 % 16S rRNA gene sequence similarity with the type strain of <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42636" xlink:type="simple">Faecalibacterium duncaniae</jats:ext-link>
</jats:named-content>
</jats:italic>. The aim of this study was to evaluate the taxonomic relationship between <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42294" xlink:type="simple">F. hominis</jats:ext-link>
</jats:named-content>
</jats:italic> and <jats:italic>F. duncaniae. F. duncaniae</jats:italic> JCM 31915<jats:sup>T</jats:sup> showed 73.0 % digital DNA–DNA hybridization (dDDH) value with <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42294" xlink:type="simple">F. hominis</jats:ext-link>
</jats:named-content>
</jats:italic> JCM 39347<jats:sup>T</jats:sup>. The average nucleotide identity (ANI) value between these two strains was 96.7 %. These results indicate that <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42636" xlink:type="simple">F. duncaniae</jats:ext-link>
</jats:named-content>
</jats:italic> JCM 31915<jats:sup>T</jats:sup> and <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42294" xlink:type="simple">F. hominis</jats:ext-link>
</jats:named-content>
</jats:italic> JCM 39347<jats:sup>T</jats:sup> represent members of the same species. Based on these data, we propose <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42294" xlink:type="simple">Faecalibacterium hominis</jats:ext-link>
</jats:named-content>
</jats:italic> as a later heterotypic synonym of <jats:italic>
<jats:named-content content-type="species">
<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.42636" xlink:type="simple">Faecalibacterium duncaniae</jats:ext-link>
</jats:named-content>
</jats:italic>. An emended description is provided.</jats:p> -
Hiroki Tanno, Jean-Marc Chatel, Rebeca Martin, Denis Mariat, Mitsuo Sakamoto, Masao Yamazaki, Seppo Salminen, Miguel Gueimonde, Akihito Endo
FEMS Microbiology Ecology 99 ( 5 ) 2023年03月
出版者・発行元：Oxford University Press (OUP)
<jats:title>Abstract</jats:title><jats:p>Faecalibacterium prausnitzii is a promising biomarker of a healthy human microbiota. However, previous studies reported the heterogeneity of this species and found the presence of several distinct groups at the species level among F. prausnitzii strains. Our recent study revealed that methods previously developed for quantification of F. prausnitzii were not specific to the species level because of the heterogeneity within the F. prausnitzii species and the application of 16S rRNA gene, which is an invalid genetic marker for the species. Therefore, previously available data failed to provide information on different groups, which limits our understanding of the importance of this organism for host health. Here, we propose an alternative gene marker for quantification of F. prausnitzii-related taxa. A total of nine group-specific primer pairs were designed by targeting rpoA gene sequences. The newly developed rpoA-based qPCR successfully quantified targeted groups. Application of the developed qPCR assay in six healthy adults revealed marked differences in abundance and prevalence among the different targeted groups in stool samples. The developed assay will facilitate detailed understanding of the impact of Faecalibacterium populations at the group level on human health and to understand the links between depletion of specific groups in Faecalibacterium and different human disorders.</jats:p>
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NISHIMURA Hiroya, SHIWA Yuh, TOMITA Satoru, ENDO Akihito
Bioscience of Microbiota, Food and Health advpub ( 0 ) 29 - 42 2023年
記述言語：英語 出版者・発行元：BMFH Press
<p>Cocoa bean fermentation is typically performed in a spontaneous manner on farms in tropical countries or areas and involves several microbial groups. Metabolism by microbes markedly affects the quality of cocoa beans fermented and the chocolate produced thereof. The present study characterized the microbiota and their metabolic profiles in temperature- and humidity-controlled intra-factory cocoa fermentation in a semitropical area of Japan. Although environmental factors were uniform, the microbiota of cocoa beans subjected to intra-factory fermentation was not stable between tests, particularly in terms of the cell count levels and species observed. Fermentation was sometimes delayed, and fermenting microbes were present at very low levels after 24 hr of fermentation. Due to the unstable microbiota, the profiles of water-soluble compounds differed between tests, indicating the unstable qualities of the fermented cocoa beans. These results suggest the necessity of starter cultures not only in on-farm fermentation but also in machine-controlled intra-factory cocoa fermentation.</p>
書籍等出版物 【 表示 ／ 非表示 】
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Chapter 1. Isolation and Identification of Lactic Acid Bacteria from Environmental Samples.
Endo A, Tanizawa Y and Arita M. 著 Kanauchi M. 編（ 担当： 共著）
Springer Nature 2019年01月
記述言語：英語 著書種別：学術書
乳酸菌の分離、同定の方法について解説した
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Chapter 5. Fructophilic lactic acid bacteria: An overview of their unique properties
Endo A. 著 Vinderola G, Ouwehand A, Salminen S, von Wright A 編（ 担当： 単著）
CRC Press 2019年01月
記述言語：英語 著書種別：学術書
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1-43. 乳酸菌の種類と分類
遠藤明仁 著, 北本勝ひこ、春田伸、丸山潤一、後藤慶一、尾花望、齋藤勝晴 編（ 担当： 単著）
朝倉書店 2017年01月
記述言語：日本語 著書種別：学術書
乳酸菌の特徴について解説した
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Chapter 1: Isolation, Identification and Characterisation of Potential New Probiotics. In Advances in Probiotic Technology.
Endo A. and Gueimonde M., P. Foerst and C. Santivarangkna 編（ 担当： 共著）
CRC Press 2015年08月 （ ISBN:9781498734530 ）
記述言語：英語 著書種別：学術書
MISC 【 表示 ／ 非表示 】
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Fructophilic Lactic Acid Bacteria, a Unique Group of Fructose-fermenting Microbes 査読あり
Endo A, Maeno S, Tanizawa Y, Kneifel W, Arita M, Dicks L, Salminen S.
Applied and Environmental Microbiology 84 0 - 0 2018年08月
担当区分：筆頭著者 記述言語：英語 掲載種別：記事・総説・解説・論説等（学術雑誌） 出版者・発行元：American Society for Microbiology
フルクトフィリック乳酸菌の分類、生理学的・遺伝学的特徴、生態などについて概説した。
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Safety of Novel Microbes for Human Consumption: Practical Examples of Assessment in the European Union. 査読あり
Brodmann T, Endo A, Gueimonde M, Vinderola G, Kneifel W, de Vos WM, Salminen S, Gómez-Gallego C.
Frontiers in Microbiology 8 1725 2017年09月
記述言語：英語 掲載種別：記事・総説・解説・論説等（学術雑誌）
新規微生物の食品利用のための安全性について概説した。
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乳酸菌分類の現在とビフィズス菌・乳酸菌分類小委員会が提言した新規乳酸菌種提唱のための最少基準 招待あり 査読あり
平山洋佑, 遠藤 明仁
腸内細菌学雑誌 30 17 - 28 2016年01月
担当区分：筆頭著者 記述言語：日本語 掲載種別：記事・総説・解説・論説等（学術雑誌） 出版者・発行元：日本ビフィズス菌センター
乳酸菌とビフィズス菌の最新の分類状況について概説した。
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Evolution and diversification of oxygen metabolisms of aerotolerant anaerobes in the order Bacillales and other bacterial taxonomic groups
Mochizuki, D., Tanaka, N., Ishikawa, M., Endo, A., Shiwa, Y., Fujita, N., Sato, J. & Niimura, Y.
The Bulletin of BISMiS 2013年01月
担当区分：筆頭著者 記述言語：英語 掲載種別：記事・総説・解説・論説等（学術雑誌） 出版者・発行元：Bergey’s International Society for Microbial Systematics
Bacillales 目とその近縁細菌群に属する酸素耐性嫌気性菌中の酸素代謝酵素及び遺伝子の分布と進化を概説した。
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Fructophilic lactic acid bacteria inhabit fructose-rich niches in nature
Endo, A.
Microbial Ecology in Health and Disease 2012年06月
記述言語：英語 掲載種別：記事・総説・解説・論説等（国際会議プロシーディングズ） 出版者・発行元：Society for Microbial Ecology and Disease
フルクトフィリック乳酸菌の分類、多様性、生理学、生態などを概説した。
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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フルクトフィリック乳酸菌のハチプロバイオティクスとしての利用
2014年04月 - 2017年03月
科学研究費補助金 若手研究(B)
担当区分：研究代表者