Updated on 2024/01/10

写真b

SHIMOI Gaku

Associate Professor

Title

Associate Professor

Laboratory Address

北海道網走市八坂196

Laboratory Phone number

0152-48-3830

Laboratory Fax number

0152-48-3830

External Link

From Graduate School 【 display / non-display

  • Tokyo University of Agriculture   Graduate School, Division of Bioindustry   Doctoral program (second term)   Completed

    2001.04 - 2004.03

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    Country:Japan

Degree 【 display / non-display

  • 生物産業学博士 ( 2004.03   東京農業大学 )

Employment Record in Research 【 display / non-display

  • Tokyo University of Agriculture   Faculty of Bio-Industry

    2004.04 - 2005.03

  • Tokyo University of Agriculture   Faculty of Bio-Industry

    2005.04 - 2006.03

  • Tokyo University of Agriculture   Faculty of Bio-Industry

    2006.04 - 2007.03

  • Tokyo University of Agriculture   Faculty of Bio-Industry   Research Assistant

    2007.04 - 2008.03

  • Tokyo University of Agriculture   Faculty of Bio-Industry   Assistant Professor

    2008.04 - 2014.09

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Professional Memberships 【 display / non-display

  • 日本繁殖生物学会

    2013.04

Papers 【 display / non-display

  • Post-ovulatory oocyte aging affects the initial differentiation into trophectoderm lineage after fertilization in mice Reviewed

    Gaku Shimoi, Chiho Moronaga, Ryuji Jozawa, Ken-ichi Kudoh, Yuichi Kameyama

    Journal of Mammalian Ova Research   40 ( 2 )   2023.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Post-ovulatory oocyte aging degrades the quality and developmental competence of embryos for implantation. To evaluate the effects of oocyte aging on the initial differentiation of embryos, we examined trophectoderm (TE) formation and the expressions of TE differentiation-related signaling molecules in embryos derived from in vitro aged oocytes.

  • Breeding of long-clawed shrews, <i>Sorex unguiculatus</i>, in captivity Reviewed

    Okimoto Kohei, D. Ohdachi Satoshi, Katsuyama Yuriko, Shimoi Gaku, Wada Kenta, Kameyama Yuichi

    Honyurui Kagaku (Mammalian Science)   63 ( 2 )   143 - 155   2023.07

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    Language:Japanese   Publisher:The Mammal Society of Japan  

    <p>This report describes the breeding of long-clawed shrews under laboratory conditions. During pairing, females waggled their waists, causing horizontal shaking of the tail, and walked around the males. Mounting was observed on the second day of pairing. In the two pairs with successful subsequent deliveries, mounting was observed 51 and 9 times with average (±<i>SD</i>) durations of 39 ± 59 and 56 ± 54 s, respectively. Similar multiple-mounting behavior was also observed in those pairs for which mating attempts proved unproductive. The gestational period was approximately 21–22 days. Weaning was successful in 4 of the 12 observed deliveries, and the weaning period was approximately 31–36 days. During the lactation period, the females constructed dome-like nests using straw mulch. The activity time of lactating mothers increased as the lactation period advanced. Weanlings attained almost the same body size as subadults, although their body weight did not increase until nine weeks after weaning.</p>

    DOI: 10.11238/mammalianscience.63.143

  • エミュー卵殻粉末の経口摂取が卵巣摘出マウスの骨代謝に及ぼす影響

    下井 岳, 後藤果穂

    東京農業大学生物産業学部網走寒冷地農場年報トウフツ   ( 25 )   60 - 66   2023.01

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (other academic)  

    エストロゲン欠乏を主要因とする閉経後骨粗鬆症のモデルとして位置づけられる「卵巣摘出による骨量減少モデル動物(Ovariectomized animals; OVX)」を用いて、本研究ではエミュー卵殻粉末の摂取がOVXマウスの骨塩量に及ぼす影響について検証した。

  • Effects of post-ovulatory aging on centromeric cohesin protection in murine MII oocytes Reviewed

    Gaku Shimoi, Rico Wakabayashi, Ryu Ishikawa, Yuichi Kameyama

    Reproductive Medicine and Biology   21 ( 1 )   e12433   2021.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Post-ovulatory aging causes a high frequency of aneuploidy during meiosis II in mouse oocytes, irrespective of maternal age. In this study, we evaluated the effects of post-ovulatory oocyte aging on the protection of chromosomal cohesion involved in aneuploidy, and verified the relationship between PP2A or SGO2 expression and the phosphorylation level of REC8 in oocytes. The findings show that post-ovulatory aging destabilizes the centromeric cohesin protection in oocytes and can cause aneuploidy, which is often observed in aged oocytes during meiosis II.

    DOI: 10.1002/rmb2.12433

  • Mitochondrial DNA variations in Japanese farmed emu populations Reviewed

    Koshiishi Yuichi, Ukita Misuzu, Murata-Okubo Michiko, Fujisawa Shin-ichiro, Shimoi Gaku, Hirayama Hiroki, Kameyama Yuichi, Souma Kousaku, Wada Kenta

    Journal of Veterinary Medical Science   82 ( 6 )   731 - 734   2020.04

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPANESE SOCIETY OF VETERINARY SCIENCE  

    The emu (Dromaius novaehollandiae) is a new poultry. In this study, we investigated the haplotype composition of mitochondrial DNA among emu populations farmed in Japan. We sequenced the D-loop region in 109 individuals, and detected four substitution sites and three haplotypes (Hap-a, -b, and -c).

    DOI: 10.1292/jvms.19-0693

    PubMed

    CiNii Articles

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Honours, Awards and Prizes 【 display / non-display

  • ISIVF2023 Poster Presentation Award

    2023.11   Exposure to IGFBP-rP1 during the oocyte maturation process inhibits IGF-1R and AKT activity in murine MII oocytes and embryos

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    Award type:International academic award (Japan or overseas) 

  • 第62回北海道生殖医学会学術講演会優秀演題賞

    2020.02   北海道生殖医学会   プロテオグリカンがマウス体外加齢由来胚のミトコンドリア膜電位に及ぼす影響

    下井 岳、蓮見奈々子、佟 忻、鈴木雅子、内沢秀光、工藤謙一、亀山 祐一

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    Award type:International academic award (Japan or overseas)  Country:Japan

  • 第60回日本卵子学会学術集会・学術奨励賞口頭部門

    2019.05   日本卵子学会   IGFBP-rP1がマウス卵子の成熟・受精・初期発生に及ぼす影響

    佟 忻,井関大志,和田健太,亀山祐一,下井 岳

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    Award type:International academic award (Japan or overseas)  Country:Japan

  • 第61回北海道生殖医学会学術講演会優秀演題賞

    2019.02   北海道生殖医学会   体外加齢がマウスMII期卵子のミトコンドリア膜電位に及ぼす影響

    下井 岳,羽田凉穂,佟 忻,亀山祐一

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    Award type:International academic award (Japan or overseas)  Country:Japan

  • 第59回北海道生殖医学会学術講演会優秀演題賞

    2017.02   北海道生殖医学会   母体の加齢がマウス体外成熟卵子のMII期におけるコヒーシンの発現に及ぼす影響

    下井 岳、小泉智里、小竹祐太郎、亀山祐一

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Presentations 【 display / non-display

  • Exposure to IGFBP-rP1 during the oocyte maturation process inhibits IGF-1R and AKT activity in murine MII oocytes and embryos International conference

    Jyozawa R, Kameyama Y and Shimoi G

    21st World Congress on In Vitro Fertilization  2023.11  International Society for In Vitro Fertilization

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    Event date: 2023.11

    Language:English   Presentation type:Poster presentation  

    Venue:Osaka International Convention Center, Osaka, JAPAN  

    In this study, we investigated the effects of IGFBP-rP1 exposure on the maturation process of immature oocytes and the activity of IGF-1R and its downstream factors during early development.

  • Effects of proteoglycans on the expression of apoptosis-related factors in murine embryos International conference

    Shimoi G, Jyozawa R, Kudoh K and Kameyama Y

    21st World Congress on In Vitro Fertilization  2023.11  International Society for In Vitro Fertilization

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Osaka International Convention Center, Osaka, JAPAN  

    This study aimed to examine the effects of PGs on mitochondrial MP and expression of apoptosis regulators in murine embryos.

  • 妊娠マウスの過排卵誘起とそれで得られた卵子の初期発生

    亀山祐一, 永木 渉, 下井 岳, 如澤竜治, 和田健太

    第64回 日本卵子学会 

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    Event date: 2023.05

    Presentation type:Poster presentation  

    Venue:つくば国際会議場(茨城県つくば市)  

    哺乳動物は一部の例外を除けば、妊娠中の排卵、受精、発生は起こらない。演者らは誤って妊娠マウスを過排卵誘起したところ、排卵とその卵子がIVFで卵割することを観察した。本研究では妊娠マウスを過排卵誘起し、排卵とIVF後の初期発生を観察した。また一部の例では妊娠の継続、産仔の発育を観察した。

  • Thioredoxinはマウス体外加齢卵子の抗酸化に有効か

    下井 岳, 大井七彦, 如澤 竜治, 亀山 祐一

    第64回 日本卵子学会 

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    Event date: 2023.05

    Presentation type:Poster presentation  

    Venue:つくば国際会議場(茨城県つくば市)  

    排卵後に体外で一定時間経過した卵子に対する酸化ストレスの軽減を目的に、体外加齢卵子におけるTrxのレドックス活性を評価し、マウス由来組換えタンパク質TRX1(mrTRX-1)を用いて外因性Trxが卵子の抗酸化能に及ぼす影響について検証した。

  • 暑熱に暴露したマウスから回収した精巣上体尾部精子の受精能

    亀山祐一, 大木崚雅, 下井 岳, 和田健太

    第65回 北海道生殖医学会 

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    Event date: 2023.02

    Presentation type:Oral presentation (general)  

    Venue:北海道大学医学部学友会館(北海道札幌市)  

    ICR マウスの雄を 35℃に 7 日間暴露し、精巣サイズ、精巣上体精子の正常性、受精能に関する指標を観察した。暑熱暴露で精巣は退縮すると同時に T 分泌が減少、精巣上体尾部の精子も形態正常性、生存性、運動性、受精能が低下し、得られた受精卵の発生率は低下することが示された。

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Committee Memberships 【 display / non-display

  • 日本卵子学会   代議員  

    2023.03   

Attractiveness of Research 【 display / non-display

  • オホーツクの大地で自然を感じながら勉強しよう。