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Title |
Professor |
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Laboratory Address |
北海道網走市八坂196 |
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Laboratory Phone number |
0152-48-3830 |
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Laboratory Fax number |
0152-48-3830 |
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External Link |
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SHIMOI Gaku Professor |
From Graduate School 【 display / non-display 】
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Tokyo University of Agriculture Graduate School, Division of Bioindustry Doctoral program (second term) Completed
2001.04 - 2004.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Bio-Industry
2004.04 - 2005.03
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Tokyo University of Agriculture Faculty of Bio-Industry
2005.04 - 2006.03
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Tokyo University of Agriculture Faculty of Bio-Industry
2006.04 - 2007.03
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Tokyo University of Agriculture Faculty of Bio-Industry Research Assistant
2007.04 - 2008.03
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Tokyo University of Agriculture Faculty of Bio-Industry Assistant Professor
2008.04 - 2014.09
Papers 【 display / non-display 】
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Post-ovulatory oocyte aging affects the initial differentiation into trophectoderm lineage after fertilization in mice Reviewed
Gaku Shimoi, Chiho Moronaga, Ryuji Jozawa, Ken-ichi Kudoh, Yuichi Kameyama
Journal of Mammalian Ova Research 40 ( 2 ) 2023.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Post-ovulatory oocyte aging degrades the quality and developmental competence of embryos for implantation. To evaluate the effects of oocyte aging on the initial differentiation of embryos, we examined trophectoderm (TE) formation and the expressions of TE differentiation-related signaling molecules in embryos derived from in vitro aged oocytes.
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Breeding of long-clawed shrews, <i>Sorex unguiculatus</i>, in captivity Reviewed
Okimoto Kohei, D. Ohdachi Satoshi, Katsuyama Yuriko, Shimoi Gaku, Wada Kenta, Kameyama Yuichi
Honyurui Kagaku (Mammalian Science) 63 ( 2 ) 143 - 155 2023.07
Language：Japanese Publisher：The Mammal Society of Japan
<p>This report describes the breeding of long-clawed shrews under laboratory conditions. During pairing, females waggled their waists, causing horizontal shaking of the tail, and walked around the males. Mounting was observed on the second day of pairing. In the two pairs with successful subsequent deliveries, mounting was observed 51 and 9 times with average (±<i>SD</i>) durations of 39 ± 59 and 56 ± 54 s, respectively. Similar multiple-mounting behavior was also observed in those pairs for which mating attempts proved unproductive. The gestational period was approximately 21–22 days. Weaning was successful in 4 of the 12 observed deliveries, and the weaning period was approximately 31–36 days. During the lactation period, the females constructed dome-like nests using straw mulch. The activity time of lactating mothers increased as the lactation period advanced. Weanlings attained almost the same body size as subadults, although their body weight did not increase until nine weeks after weaning.</p>
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エミュー卵殻粉末の経口摂取が卵巣摘出マウスの骨代謝に及ぼす影響
下井 岳, 後藤果穂
東京農業大学生物産業学部網走寒冷地農場年報トウフツ ( 25 ) 60 - 66 2023.01
Authorship：Lead author Language：Japanese Publishing type：Research paper (other academic)
エストロゲン欠乏を主要因とする閉経後骨粗鬆症のモデルとして位置づけられる「卵巣摘出による骨量減少モデル動物（Ovariectomized animals; OVX）」を用いて、本研究ではエミュー卵殻粉末の摂取がOVXマウスの骨塩量に及ぼす影響について検証した。
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Effects of post-ovulatory aging on centromeric cohesin protection in murine MII oocytes Reviewed
Gaku Shimoi, Rico Wakabayashi, Ryu Ishikawa, Yuichi Kameyama
Reproductive Medicine and Biology 21 ( 1 ) e12433 2021.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Post-ovulatory aging causes a high frequency of aneuploidy during meiosis II in mouse oocytes, irrespective of maternal age. In this study, we evaluated the effects of post-ovulatory oocyte aging on the protection of chromosomal cohesion involved in aneuploidy, and verified the relationship between PP2A or SGO2 expression and the phosphorylation level of REC8 in oocytes. The findings show that post-ovulatory aging destabilizes the centromeric cohesin protection in oocytes and can cause aneuploidy, which is often observed in aged oocytes during meiosis II.
DOI： 10.1002/rmb2.12433
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Mitochondrial DNA variations in Japanese farmed emu populations Reviewed
Koshiishi Yuichi, Ukita Misuzu, Murata-Okubo Michiko, Fujisawa Shin-ichiro, Shimoi Gaku, Hirayama Hiroki, Kameyama Yuichi, Souma Kousaku, Wada Kenta
Journal of Veterinary Medical Science 82 ( 6 ) 731 - 734 2020.04
Language：English Publishing type：Research paper (scientific journal) Publisher：JAPANESE SOCIETY OF VETERINARY SCIENCE
The emu (Dromaius novaehollandiae) is a new poultry. In this study, we investigated the haplotype composition of mitochondrial DNA among emu populations farmed in Japan. We sequenced the D-loop region in 109 individuals, and detected four substitution sites and three haplotypes (Hap-a, -b, and -c).
DOI： 10.1292/jvms.19-0693
Honours, Awards and Prizes 【 display / non-display 】
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第66回北海道生殖医学会学術講演会優秀演題賞
2024.02 北海道生殖医学会 プロテオグリカンの長期経口摂取がマウス卵巣の抗老化に及ぼす影響
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ISIVF2023 Poster Presentation Award
2023.11 Exposure to IGFBP-rP1 during the oocyte maturation process inhibits IGF-1R and AKT activity in murine MII oocytes and embryos
Award type：International academic award (Japan or overseas)
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第62回北海道生殖医学会学術講演会優秀演題賞
2020.02 北海道生殖医学会 プロテオグリカンがマウス体外加齢由来胚のミトコンドリア膜電位に及ぼす影響
下井 岳、蓮見奈々子、佟 忻、鈴木雅子、内沢秀光、工藤謙一、亀山 祐一
Award type：International academic award (Japan or overseas) Country：Japan
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第60回日本卵子学会学術集会・学術奨励賞口頭部門
2019.05 日本卵子学会 IGFBP-rP1がマウス卵子の成熟・受精・初期発生に及ぼす影響
佟 忻，井関大志，和田健太，亀山祐一，下井 岳
Award type：International academic award (Japan or overseas) Country：Japan
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第61回北海道生殖医学会学術講演会優秀演題賞
2019.02 北海道生殖医学会 体外加齢がマウスMII期卵子のミトコンドリア膜電位に及ぼす影響
下井 岳，羽田凉穂，佟 忻，亀山祐一
Award type：International academic award (Japan or overseas) Country：Japan
Presentations 【 display / non-display 】
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プロテオグリカンの経口摂取がマウス卵巣の抗老化に及ぼす影響
下井 岳, 荒山佑紀, 如澤竜治, 鎌倉彩百, 工藤謙一, 亀山祐一
第66回 北海道生殖医学会 2024.02
Event date： 2024.02
Language：Japanese Presentation type：Oral presentation (general)
Venue：札幌医科大学臨床教育研究棟講堂（北海道札幌市）
抗炎症や細胞増殖作用を持つプロテオグリカン(PG)は、抗老化物質としてその効果が皮膚や軟骨組織で確認されているが、性腺組織に対する効果は演者らの知る限り報告がない。そこで、マウスにPGを長期間経口摂取させ卵巣の抗老化に対する効果を検証した。ガン制御因子p53や細胞周期阻害因子ｐ21の発現低下から、PGの摂取が卵巣における細胞老化(老化細胞の蓄積)を抑制する可能性が示唆された。
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アルコール依存モデルマウス由来卵母細胞の単為発生
亀山祐一, 浅原隼風, 下井 岳, 鎌倉彩百, 如澤竜治
第66回 北海道生殖医学会 2024.02
Event date： 2024.02
Language：Japanese Presentation type：Oral presentation (general)
Venue：札幌医科大学臨床教育研究棟講堂（北海道札幌市）
アルコール（Alc）依存モデルマウスで、過排卵処理後の採卵成績、卵母細胞の単為発生を観察した。10または20%のAlcをICRに 30～40日間自由摂取させても、摂水、摂餌、増体重、発情周期、過排卵処理で得られた卵子の数・品質・単為発生に大きな影響はなかった。
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陰嚢の温湯・超音波曝露による一時的雄性不妊マウスモデルの開発
鎌倉彩百, 下井 岳, 如澤竜治, 亀山祐一
第66回 北海道生殖医学会 2024.02
Event date： 2024.02
Language：Japanese Presentation type：Oral presentation (general)
Venue：札幌医科大学臨床教育研究棟講堂（北海道札幌市）
陰嚢を超音波治療器で処置すると精子形成が阻害され、一定期間後に回復することがラットやサル類で知られている。演者は汎用理化機器の超音波破砕機でマウスの陰嚢を処置し、一時的な雄性不妊モデル作製を試みた。その結果、超音波処理の影響は、処理温度の上昇によって増強されることが示された。
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Exposure to IGFBP-rP1 during the oocyte maturation process inhibits IGF-1R and AKT activity in murine MII oocytes and embryos International conference
Jyozawa R, Kameyama Y and Shimoi G
21st World Congress on In Vitro Fertilization 2023.11 International Society for In Vitro Fertilization
Event date： 2023.11
Language：English Presentation type：Poster presentation
Venue：Osaka International Convention Center, Osaka, JAPAN
In this study, we investigated the effects of IGFBP-rP1 exposure on the maturation process of immature oocytes and the activity of IGF-1R and its downstream factors during early development.
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Effects of proteoglycans on the expression of apoptosis-related factors in murine embryos International conference
Shimoi G, Jyozawa R, Kudoh K and Kameyama Y
21st World Congress on In Vitro Fertilization 2023.11 International Society for In Vitro Fertilization
Event date： 2023.11
Language：English Presentation type：Oral presentation (general)
Venue：Osaka International Convention Center, Osaka, JAPAN
This study aimed to examine the effects of PGs on mitochondrial MP and expression of apoptosis regulators in murine embryos.
Attractiveness of Research 【 display / non-display 】
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オホーツクの大地で自然を感じながら勉強しよう。