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NAKAZAWA Takanobu Professor |
From School 【 display / non-display 】
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The University of Tokyo Faculty of Agriculture Graduated
1992.04 - 1996.03
From Graduate School 【 display / non-display 】
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The University of Tokyo Graduate School, Division of Medical Sciences Doctor Course Completed
1998.04 - 2002.03
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The University of Tokyo Master Course Completed
1996.04 - 1998.03
Degree 【 display / non-display 】
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Ph.D ( 2002.03 The University of Tokyo )
Employment Record in Research 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Life Sciences Department of Bioscience Professor
2020.04
External Career 【 display / non-display 】
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Tokyo University of Agriculture Professor
2020.04
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Osaka University
2020.04
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Osaka University Graduate School of Dentistry Associate Professor
2016.04 - 2020.03
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Osaka University
2013.09 - 2016.03
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The University of Tokyo
2011.06 - 2013.08
Research Areas 【 display / non-display 】
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Life Science / Molecular biology
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Life Science / Basic brain sciences
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Life Science / Pharmacology
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Life Science / Psychiatry
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Life Science / Neuroscience-general
Research Interests 【 display / non-display 】
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精神疾患研究
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疾患iPS細胞
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分子細胞生物学
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神経科学
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iPS細胞
Papers 【 display / non-display 】
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Modeling mental disorders in a dish. International journal
Takanobu Nakazawa
Psychiatry and clinical neurosciences 77 ( 6 ) 307 - 307 2023.06
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Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. International journal
Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto
Science advances 8 ( 11 ) eabi6375 2022.03
Language：English Publishing type：Research paper (scientific journal)
The processing of stress responses involves brain-wide communication among cortical and subcortical regions; however, the underlying mechanisms remain elusive. Here, we show that the claustrum (CLA) is crucial for the control of stress-induced anxiety-related behaviors. A combined approach using brain activation mapping and machine learning showed that the CLA activation serves as a reliable marker of exposure to acute stressors. In TRAP2 mice, which allow activity-dependent genetic labeling, chemogenetic activation of the CLA neuronal ensemble tagged by acute social defeat stress (DS) elicited anxiety-related behaviors, whereas silencing of the CLA ensemble attenuated DS-induced anxiety-related behaviors. Moreover, the CLA received strong input from DS-activated basolateral amygdala neurons, and its circuit-selective optogenetic photostimulation temporarily elicited anxiety-related behaviors. Last, silencing of the CLA ensemble during stress exposure increased resistance to chronic DS. The CLA thus bidirectionally controls stress-induced emotional responses, and its inactivation can serve as a preventative strategy to increase stress resilience.
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Toward recovery in schizophrenia: current concepts, findings, and future research directions. International journal
Toshiaki Onitsuka, Yoji Hirano, Takanobu Nakazawa, Kayo Ichihash, Kenichiro Miura, Ken Inada, Ryo Mitoma, Norio Yasui-Furukori, Ryota Hashimoto
Psychiatry and clinical neurosciences 76 ( 7 ) 282 - 291 2022.03
Language：English Publishing type：Research paper (scientific journal)
Schizophrenia was initially defined as "dementia praecox" by E. Kraepelin, which implies progressive deterioration. However, recent studies have revealed that early effective intervention may lead to social and functional recovery in schizophrenia. In this review, we provide an overview of current concepts in schizophrenia and pathophysiological hypotheses. In addition, we present recent findings from clinical and basic research on schizophrenia. Recent neuroimaging and neurophysiological studies have consistently revealed specific biological differences in the structure and function of the brain in those with schizophrenia. From a basic research perspective, to determine the essential pathophysiology underlying schizophrenia, it is crucial that findings from all lines of inquiry-induced pluripotent stem cell (iPSC)-derived neural cells from patients, murine models expressing genetic mutations identified in patients, and patient clinical data-be integrated to contextualize the analysis results. However, the findings remain insufficient to serve as a diagnostic tool or a biomarker for predicting schizophrenia-related outcomes. Collaborations to conduct clinical research based on the patients' and their families' values are just beginning, and further development is expected. This article is protected by copyright. All rights reserved.
DOI： 10.1111/pcn.13342
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Modeling schizophrenia with iPS cell technology and disease mouse models. International journal
Takanobu Nakazawa
Neuroscience research 175 46 - 52 2022.02
Language：English Publishing type：Research paper (scientific journal)
Induced pluripotent stem cell (iPSC) technology, which enables the direct analysis of neuronal cells with the same genetic background as patients, has recently garnered significant attention in schizophrenia research. This technology is important because it enables a comprehensive interpretation using mice and human clinical research and cross-species verification. Here I review recent advances in modeling schizophrenia using iPSC technology, alongside the utility of disease mouse models.
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Trends in big data analyses by multicenter collaborative translational research in psychiatry. Reviewed International journal
Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
Psychiatry and clinical neurosciences 76 ( 1 ) 1 - 14 2022.01
Language：English Publishing type：Research paper (scientific journal)
The underlying pathologies of psychiatric disorders, which cause substantial personal and social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core pathological mechanisms underlying psychiatric disorders, in addition to laboratory-based research that incorporates the latest findings, it is necessary to conduct large-sample-size research and verify reproducibility. For this purpose, it is critical to conduct multicenter collaborative research across various fields, such as psychiatry, neuroscience, molecular biology, genomics, neuroimaging, cognitive science, neurophysiology, psychology and pharmacology. Moreover, collaborative research plays an important role in the development of young researchers. In this respect, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium and Cognitive Genetics Collaborative Research Organization (COCORO) have played important roles. In this review, we first overview the importance of multicenter collaborative research and our target psychiatric disorders. Then, we introduce research findings on the pathophysiology of psychiatric disorders from neurocognitive, neurophysiological, neuroimaging, genetic, and basic neuroscience perspectives, focusing mainly on the findings obtained by COCORO. It is our hope that multicenter collaborative research will contribute to the elucidation of the pathological basis of psychiatric disorders. This article is protected by copyright. All rights reserved.
DOI： 10.1111/pcn.13311
Misc 【 display / non-display 】
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Neuron-specific VPAC2 receptor overexpression leads to cognitive impairment in mice
古庵大地, 今戸瑛二, 浅野智志, 浅野智志, CHEN Lu, 宮岡辰典, 山田めゐ, 石本憲司, 石本憲司, 中川晋作, 中川晋作, 早田敦子, 早田敦子, 中澤敬信, 原田彰宏, 橋本均, 橋本均, 橋本均, 橋本均, 橋本均, WASCHEK James, 吾郷由希夫, 吾郷由希夫, 吾郷由希夫, 吾郷由希夫
日本薬学会年会要旨集(Web) 141st 2021
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Behavioral and morphological abnormalities in a mouse model with copy number variation of the vasoactive intestinal peptide receptor VIPR2 gene
陳露, 竹内修斗, 山田めゐ, 宮岡辰典, 山口拓海, 中澤敬信, 中澤敬信, 中澤敬信, 中川晋作, 中川晋作, 橋本均, 橋本均, 橋本均, 橋本均, 吾郷由希夫, 吾郷由希夫, 吾郷由希夫
日本薬理学雑誌 155 ( Supplement ) 2020
Honours, Awards and Prizes 【 display / non-display 】
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大阪大学総長奨励賞
2014.07 大阪大学
Scientific Research Funds Acquisition Results 【 display / non-display 】
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Molecular analysis of the effects of environmental factors on higher brain function using iPSC technology and mice
Grant number：22K18655 2022.06 - 2024.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory) Grant-in-Aid for Challenging Research (Exploratory)
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
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Modeling autism spectrum disorders with iPSC derived from patients and model mice
Grant number：21H02628 2021.04 - 2024.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research Basic Research (B)
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
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Modeling psychiatric disorders with iPSC derived from patients
Grant number：21H00213 2021.04 - 2023.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas
Grant amount：\7800000 （ Direct Cost: \6000000 、 Indirect Cost：\1800000 ）
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社会行動制御に関わる神経細胞の単一細胞レベルの解析及びその活動操作の基盤技術開発
2020.10 - 2022.03
科学研究費補助金 挑戦的萌芽研究
中澤 敬信
Authorship：Principal investigator
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社会行動制御に関わる神経細胞の単一細胞レベルの解析及びその活動操作の基盤技術開発
Grant number：20K21464 2020.07 - 2022.03
日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽) 挑戦的研究(萌芽)
中澤 敬信
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
自閉症は、社会的関係等に障害が認められる頻度が高い神経発達障害の1つである。病態の分子メカニズムはほとんど不明であり、多数の患者を説明できる明確な分子病因は同定されていない。本研究では、野生型マウスおよび申請者が独自に開発した妥当性の高いヒト型自閉症モデルマウス群を用いて、単一細胞レベルの解析を実施し、社会行動の制御に関わる神経細胞の機能解析、および社会行動を制御する神経回路の同定および同定した回路の操作の基盤技術を開発することを目的としている。本年度は、POGZ変異マウスにおける社会行動異常の分子メカニズムを明らかにするため、薬理学的な行動実験を実施した。その結果、オキシトシンの投与により、POGZ変異マウスの社会行動異常が回復することが明らかになった（Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ WT/Q1038R mouse model of autism spectrum disorder, Kitagawa et al., Molecular Brain 2020）。また、POGZ変異マウスではオキシトシン受容体の発現量が低下していることが明らかになった一方で、オキシトシン産生神経細胞には異常がないことが示唆された。さらに、POGZがオキシトシン受容体遺伝子のプロモーターに結合していることを明らかにした。これらの結果は、POGZがオキシトシン受容体の発現制御を通じて、オキシトシンシグナルを調節していることを示唆している。本年度は、POGZ変異マウスの社会行動異常の分子基盤の一端を明らかにすることができた。この成果は、単一細胞レベルの社会行動制御の解析を加速させるものである。
Other External Funds 【 display / non-display 】
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分子病態に基づく自閉症の分類化のトランスレーショナル研究
2023.09 - 2029.03
武田科学振興財団 武田科学振興財団 ビジョナリーリサーチ助成（ステップ）
中澤 敬信、中澤敬信
Authorship：Principal investigator
Grant amount：\10000000
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自閉症における社会性相互作用障害に注目した環境要因の中枢分子薬理学研究
2021.04 - 2025.03
旭硝子財団 旭硝子財団 ステップアップ研究助成金
中澤敬信
Grant type：Competitive
Grant amount：\10000000
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分子病態に基づく自閉症の分類化のトランスレーショナル研究
2020.10 - 2022.10
武田科学振興財団 武田科学振興財団 ビジョナリーリサーチ助成（ホップ）
中澤 敬信
Authorship：Principal investigator Grant type：Competitive
Grant amount：\5000000
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疾患iPS細胞由来の脳3次元培養を用いた自閉症の分子病態解析
2020.04 - 2025.03
内藤記念科学財団 第52回 内藤記念科学奨励金
中澤 敬信、中澤敬信
Authorship：Principal investigator
Grant amount：\3000000
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自閉症に高頻度に認めるPOGZ遺伝子変異に注目した自己と他者との社会的相互作用制御の分子基盤解明
2018 - 2019
旭硝子財団 旭硝子財団 研究助成金
中澤 敬信、中澤敬信
Authorship：Principal investigator Grant type：Competitive
Grant amount：\2000000
Past of Commissioned Research 【 display / non-display 】
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iPS細胞技術とデータ科学を融合した精神疾患横断的な双方向トランスレーショナル研究
2021.07 - 2025.03
日本医療研究開発機構（AMED） 一般受託研究 The General Consignment Study
橋本亮太
Authorship：Coinvestigator(s)
Grant amount：\40000000
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神経発達障害の病態解明を目指した革新的イメージングプラットフォーム
2019.10 - 2025.03
日本医療研究開発機構（AMED） 一般受託研究 The General Consignment Study
岡部繁男
Authorship：Principal investigator
Grant amount：\55000000
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治療抵抗性統合失調症に対する客観的診断法及び実用的治療プロトコールの開発
2016.04 - 2017.03
日本医療研究開発機構（AMED） 一般受託研究 The General Consignment Study
橋本亮太
Authorship：Principal investigator
Teaching Experience 【 display / non-display 】
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分子生物学（一）
Institution：Tokyo University of Agriculture
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分子遺伝学
Institution：Tokyo University of Agriculture
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臨床薬理学演習
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臨床薬理学講義
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先端生命科学特別講義
Committee Memberships 【 display / non-display 】
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国際神経精神薬理学会2024年世界大会 組織委員会 委員
2023.04
Committee type：Academic society
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日本神経精神薬理学会 広報委員会・委員
2023.04
Committee type：Academic society
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日本神経精神薬理学会 総務委員会・委員
2023.04
Committee type：Academic society
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日本神経精神薬理学会 企画研究将来構想委員会・委員
2023.04
Committee type：Academic society
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日本農芸化学会 大会実行委員会・委員
2022.04 - 2025.03
Committee type：Academic society
Media Coverage 【 display / non-display 】
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「変異」が神経細胞の発達妨げ Newspaper, magazine
日経産業新聞 2020.03
Author：Other
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遺伝子変異で自閉症 Newspaper, magazine
毎日新聞 2020.02
Author：Other
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自閉症を薬で緩和 遺伝子変異が影響 TV or radio program
東京MXテレビ 2020.02