Updated on 2022/12/27

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MIYASHITA Shin-Ichiro

Assistant Professor

Title

Assistant Professor

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Degree 【 display / non-display

  • 博士(生物産業学) ( 2015.03 )

Employment Record in Research 【 display / non-display

  • Tokyo University of Agriculture   Faculty of Bio-Industry   Department of Food, Aroma and Cosmetic Chemistry   Assistant Professor

    2020.04

External Career 【 display / non-display

  • Boston Children’s Hospital, Harvard Medical School   Department of Urology at Boston Children’s Hospital, Department of Surgery and Department of Microbiology at Harvard Medical School   Postdoctoral fellow

    2016.01 - 2020.03

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    Country:United States

Research Areas 【 display / non-display

  • Life Science / Molecular biology

Research Interests 【 display / non-display

  • ボツリヌス神経毒素

  • 非ウィルス型DDS

  • 神経変性疾患

Papers 【 display / non-display

  • Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism Reviewed

    Shin-Ichiro Miyashita, Jie Zhang, Sicai Zhang, Charles B. Shoemaker, Min Dong

    Science Translational Medicine   13 ( 575 )   2021.01

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scitranslmed.aaz4197

  • Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium

    Cell Host & Microbe   23 ( 2 )   167 - 176   2018.02

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  • Identification and characterization of a novel botulinum neurotoxin

    Nature communications   2017.08

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  • “Non-Toxic” Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity Reviewed

    Shin-Ichiro Miyashita, Yoshimasa Sagane, Tomonori Suzuki, Takashi Matsumoto, Koichi Niwa, Toshihiro Watanabe

    Scientific Reports   6 ( 31043 )   2016.08

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep31043

  • Transport of the botulinum neurotoxin–associating protein, nontoxic nonhemagglutinin, across the rat small intestinal epithelial cell monolayer

    FEMS Microbiology letters   346 ( 1 )   73 - 80   2013.10

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    Authorship:Lead author  

    DOI: https://doi.org/10.1111/1574-6968.12205

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Industrial Property Rights 【 display / non-display

  • Catalytically inactive botulinum neurotoxin-like toxins and uses thereof

    Min Dong, Shin-Ichiro Miyashita

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    Applicant:Childrens Medical Center Corp

    Announcement no:US20220220466A1 

Scientific Research Funds Acquisition Results 【 display / non-display

  • 神経細胞へ侵入する細菌毒素を利用した病原タンパク質分解技術の開発

    Grant number:22K18198  2022.04 - 2025.03

    若手研究 

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    Authorship:Principal investigator 

  • ボツリヌス神経毒素を用いた神経細胞特異的な薬物送達システムの開発 研究課題

    Grant number:20K22722  2020.09 - 2022.03

    研究活動スタート支援 

    宮下 慎一郎

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    Authorship:Principal investigator 

  • 経口毒性が強化された変異型ボツリヌス毒素複合体の機能解析

    Grant number:22K07057  2022.04 - 2025.03

    基盤研究(C) 

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    Authorship:Coinvestigator(s)