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KAJIKAWA Akinobu Professor |
From School 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Agriculture Graduated
- 2001.03
Country：Japan
From Graduate School 【 display / non-display 】
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Gifu University United Graduate School, Division of Veterinary Medicine Doctor Course Completed
2003.10 - 2007.10
Country：Japan
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Tokyo University of Agriculture Graduate School, Division of Agriculture Doctoral program (first term) Completed
2001.04 - 2003.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Applied Biology and Chemistry Assistant Professor
2012.09 - 2016.09
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Applied Biology and Chemistry Associate Professor
2016.10 - 2018.03
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Agricultural Chemistry Associate Professor
2018.04 - 2021.03
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Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Agricultural Chemistry Professor
2021.04
External Career 【 display / non-display 】
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Colorado State University Researcher
2011.09 - 2012.09
Country：United States
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North Carolina State University Researcher
2009.06 - 2011.08
Country：United States
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国立医薬品食品衛生研究所 大学等非常勤研究員
2007.10 - 2009.05
Country：Japan
Professional Memberships 【 display / non-display 】
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腸内細菌学会
2021
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日本乳酸菌学会
2013.01
Research Areas 【 display / non-display 】
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Life Science / Applied microbiology
Papers 【 display / non-display 】
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Negative chemotaxis of Ligilactobacillus agilis BKN88 against gut-derived substances Reviewed International journal
Shunya Suzuki, Kenji Yokota, Shizunobu Igimi & Akinobu Kajikawa
Scientific Reports 13 ( 1 ) 15632 2023.09
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Nature Limited.
DOI： 10.1038/s41598-023-42840-5.
Other Link： https://www.nature.com/articles/s41598-023-42840-5
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Immunogenic Modification of Ligilactobacillus agilis by Specific Amino Acid Substitution of Flagellin Reviewed
Akinobu Kajikawa, Naoto Eguchi, Shunya Suzuki
Applied and Environmental Microbiology 2022.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Comparative analysis of immunological properties of S-layer proteins isolated from Lactobacillus strains. Reviewed
Suzuki S, Yokota K, Igimi S, Kajikawa A
Microbiology 165 ( 2 ) 188 - 196 2019.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1099/mic.0.000766
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Mucosal Immunogenicity of Genetically Modified Lactobacillus acidophilus Expressing an HIV-1 Epitope within the Surface Layer Protein Reviewed
Akinobu Kajikawa, Lin Zhang, Alora LaVoy, Sara Bumgardner, Todd R. Klaenhammer, Gregg A. Dean
PLoS One 10 ( 10 ) e0141713 2015.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Lactobacillus acidophilusのS-layerタンパク質にヒト免疫不全ウィルス由来のエピトープを挿入し、その組換え体をマウスへ経口投与することで、粘膜局所および血中にエピトープ特異的抗体産生を誘導することに成功した。
DOI： 10.1371/journal.pone.0141713
Other Link： http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141713
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Dissimilar properties of two recombinant Lactobacillus acidophilus displaying Salmonella FliC with different anchoring motifis. Reviewed
Kajikawa,A., SK.Nordone, L.Zhang, LL.Stoeker, AS.Lavoy, TR.Klaenhammer, and GA.Dean.
Applied and Environmental Microbiology 77 ( 18 ) 2011.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
菌体表層へのタンパク質の固定はアンカーの働きによるが、異なるアンカーを用いた時の免疫学的な影響は知られていない。サルモネラのFliCを2種類のアンカーによってLactobacillus acidophilusの菌体表層に提示し、その免疫学的性質をヒト末梢血から分離した樹状細胞を用いて解析した。また、表層タンパク質の消化管におけるタンパク質分解酵素への感受性も評価した。
Books and Other Publications 【 display / non-display 】
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新しい乳酸菌の機能と応用
梶川 揚申、五十君 静信（ Role： Joint author）
シーエムシー出版 2013.05
Language：Japanese Book type：Scholarly book
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乳酸菌とビフィズス菌のサイエンス
梶川揚申, 五十君静信（ Role： Joint author , 当該部分の執筆全て）
京都大学学術出版会 2010.11 （ ISBN:9784876989829 ）
Language：Japanese Book type：Scholarly book
第8章2節、568ー576頁、「乳酸菌組換えによる腸内の機能製剤の開発」（B5判、総ページ数668頁）
乳酸菌組換えによる腸内の機能製剤の開発と題し、組換え乳酸菌を用いたワクチン、アレルギー治療、炎症性腸疾患治療などの研究・開発の現状および今後の展望などを解説した。 -
腸内フローラと感染・免疫（腸内フローラシンポジウム13）
五十君静信、梶川揚申、浅井美里、佐藤英一（ Role： Joint author , 共同研究につき担当分抽出不可能）
ヤクルト・バイオサイエンス研究財団 2005.11 （ ISBN:4762230448 ）
Language：Japanese Book type：Scholarly book
A5判／200頁、149ー173頁担当、「乳酸菌を抗原運搬体とするワクチン」
平成16年に開催された腸内フローラシンポジウムにおける講演「乳酸菌を抗原運搬体とするワクチン」の発表を文字に起こしたものである。筆者らの研究を中心に同テーマについて解説した。
Misc 【 display / non-display 】
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運動性を示す有べん毛乳酸菌の生態を探る Invited Reviewed
鈴木 駿也, 梶川 揚申
日本乳酸菌学会誌 32 ( 2 ) 55 - 55 2021.06
Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本乳酸菌学会
DOI： 10.4109/jslab.32.55
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乳酸菌を用いたワクチンデリバリー技術の開発 Invited
鈴木 駿也、梶川 揚申
日本母乳保育学会雑誌 13 ( 1 ) 33 - 40 2019.06
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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乳酸菌組換えワクチンによるサルモネラ菌感染防御
梶川 揚申
日本臨床 70 ( 8 ) 1293 - 1297 2012.08
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：日本臨床社
サルモネラ菌による鶏卵汚染の制御またはヒトへの感染防御を目的とする組換え乳酸菌を用いた経口ワクチンの開発に向けた研究について解説した。
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Development of recombinant vaccines in lactobacilli for elimination of salmonella.
Kajikawa A, Igimi S.
Bioscience and Microflora 30 ( 4 ) 93 - 98 2011.11
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：BMFH出版会
第12回日本ビフィズス菌センター研究奨励賞受賞に伴い、受賞理由となったサルモネラの制御における乳酸菌のワクチン運搬に関する一連の研究を解説した。
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乳酸菌を抗原運搬体とするワクチン開発
梶川 揚申 , 五十君 靜信
化学と生物 44 ( 10 ) 652 - 654 2006.10
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings) Publisher：日本農芸化学会
乳酸菌を抗原運搬体とするワクチンの研究について、その手法や最新の研究を紹介しつつ、その課題や展望について解説した。
Honours, Awards and Prizes 【 display / non-display 】
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日本ビフィズス菌センター 研究奨励賞
2010.06 公益財団法人 日本ビフィズス菌センター
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Presentations 【 display / non-display 】
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Mucosal Immunogenicity of Recombinant Lactobacillus acidophilus Exposing HIV Epitope on the S-layer Protein International conference
Akinobu Kajikawa, Lin Zhang, Alora LaVoy, Sara Bumgardner, Todd Klaenhammer, and Gregg Dean.
第１１回国際乳酸菌シンポジウム 2014.08
Event date： 2014.08 - 2014.09
Language：English Presentation type：Oral presentation (invited, special)
Venue：Egmond aan Zee （オランダ）
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Construction of an <i>in vitro</i> human M cell model using RANKL
Ono Tatsuya, Masuda Kazuya, Kajikawa Akinobu, Yokota Kenji, Igimi Shizunobu
Proceedings for Annual Meeting of The Japanese Pharmacological Society 2021 Japanese Pharmacological Society
Language：Japanese Presentation type：Oral presentation (general)
<p>Intestinal immunity is triggered mainly by M cells existing in the intestinal tract by uptake antigens to gut associated lymphoid tissue (GALT). Recently, it has been attracting attention as a target of oral vaccine. However, primary culture is difficult because the number of M cells in vivo is small. Therefore, an in vitro human M cell model that can evaluate vaccines targeting M cells is required. If an in vitro human M cell model is constructed, we thought that we could contribute to the development of targeted oral vaccines and basic research on the function of human M cells. We constructed an in vitro human M cell model and evaluated the uptake of bacteria using cultured cells. M cell model was constructed by using the co-cultured of C2BBe1 and Raji cells, in which C2BBe1 was cultivated on the cell insert membrane and Raji cells in the well. We attempted to construct a new model by adding GST-RANKL, in which GST tag attached to RANKL(receptor activator of NF-κB ligand), a protein involved in differentiation into M cells. After co-culture, the number of fluorescent beads that was uptake by M cell (a functional evaluation), and the expression level of the M cell marker sialyl Lewis A antigen were compared with the co-culture model. In both evaluations, the new model showed improvement compared to the co-culture model.</p>