Updated on 2024/07/26

写真b

Naoto Tanaka

Professor

Title

Professor

External Link

From Graduate School 【 display / non-display

  • Tokyo University of Agriculture   Doctoral program (second term)   Completed

    1998.04 - 2001.03

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    Country:Japan

  • Tokyo University of Agriculture   Doctoral program (first term)   Completed

    1996.04 - 1998.03

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    Country:Japan

Degree 【 display / non-display

  • 博士(農芸化学) ( 2001.03   東京農業大学 )

  • 修士(農芸化学) ( 1998.03   東京農業大学 )

Employment Record in Research 【 display / non-display

  • Tokyo University of Agriculture   Faculty of Applied Bio-Science   Department of Applied Biology and Chemistry

    2001.04 - 2001.06

  • Tokyo University of Agriculture   Faculty of Applied Bio-Science   Culture Collection Center   Lecturer

    2007.04 - 2010.09

  • Tokyo University of Agriculture   Graduate School of Agriculture   Department of Environmental Symbiotic Studies   Lecturer

    2009.04 - 2010.09

  • Tokyo University of Agriculture   Graduate School of Agriculture   Department of Environmental Symbiotic Studies   Associate Professor

    2010.10 - 2013.03

  • Tokyo University of Agriculture   Faculty of Applied Bio-Science   Associate Professor

    2010.10 - 2015.03

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Research Interests 【 display / non-display

  • 微生物

Papers 【 display / non-display

  • Antimicrobial activity, genome analysis, and gene cluster encoding the plantaricin production of Lactiplantibacillus plantarum ZBK1-5 Reviewed International coauthorship International journal

    N. Choovet, T. Jirakanjanasit, P. Subphon, S. Thepsombat, E. Kingkaew, N. Tanaka, Y. Shiwa, S. Tanasupawat, S. Phuengjayaem

    ScienceAsia   50 ( 1 )   1 - 12   2024.05

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Science Society of Thailand  

    This study aimed to explore bacteriocin-producing lactic acid bacteria (LAB), identify the genes influencing bacteriocin synthesis, and assess their probiotic potential via safety evaluations both in vitro and in silico. The strain ZBK1-5, isolated from pickled ginger, was identified as Lactiplantibacillus plantarum. The bacteriocin ZBK1-5 exhibited the highest antimicrobial activity with 6,400 AU/ml at 18 h, predominantly effective against Gram-positive bacteria and stable within pH 2?9. Significantly, the genome analysis confirmed the existence of bacteriocin synthesis genes, specifically plantaricin KJ, EF, A, and N. Simultaneously, the safety evaluations showed its low risk of antibiotic resistance gene transfer, thereby emphasizing the safety profile of the strain ZBK1-5. The genetic components associated with the ability of L. plantarum ZBK1-5 to survive and adapt in gastrointestinal conditions provide additional evidence (16 genes related to acid stress and 9 genes associated with bile resistance), supporting its potential as a probiotic candidate. These findings were validated through in vitro digestion conditions, where the viability of the cells was observed to be 68.26, 66.62, and 60.91% during transit through the oral, gastrointestinal, and small intestinal phases, respectively. Additionally, the strain ZBK1-5 showed a 90.39% adhesion rate in the Caco-2 cell line. The unique characteristics of plantaricin produced by L. plantarum ZBK1-5 exhibit potent antibacterial activity, rapid time to production compared to other known plantaricins, and strain safety for application and upscaling. This research study offers significant scientific insights into L. plantarum ZBK1-5, a plantaricin producer, emphasizing its promising potential for future applications.

    DOI: 10.2306/scienceasia1513-1874.2024.046

  • Chromosome-level genome assemblies of Cutaneotrichosporon spp. (Trichosporonales, Basidiomycota) reveal imbalanced evolution between nucleotide sequences and chromosome synteny Reviewed International journal

    Yuuki Kobayashi, Ayane Kayamori, Keita Aoki, Yuh Shiwa, Minenosuke Matsutani, Nobuyuki Fujita, Takashi Sugita, Wataru Iwasaki, Naoto Tanaka & Masako Takashima

    BMC Genomics   24   609   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Since DNA information was first used in taxonomy, barcode sequences such as the internal transcribed spacer (ITS) region have greatly aided fungal identification; however, a barcode sequence alone is often insufficient. Thus, multi-gene- or whole-genome-based methods were developed. We previously isolated Basidiomycota yeasts classified in the Trichosporonales. Some strains were described as Cutaneotrichosporon cavernicola and C. spelunceum, whereas strain HIS471 remained unidentified. We analysed the genomes of these strains to elucidate their taxonomic relationship and genetic diversity.

    DOI: https://doi.org/10.1186/s12864-023-09718-2

  • Characterization and genomic analysis of Fererhizobium litorale gen. nov., sp. nov., isolated from the sandy sediments of the Sea of Japan seashore. Reviewed International coauthorship International journal

    Lyudmila Romanenko, Nadezhda Otstavnykh, Naoto Tanaka, Valeriya Kurilenko, Vasily Svetashev, Liudmila Tekutyeva, Valery Mikhailov, Marina Isaeva

    Microorganisms   11   2385   2023.09

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI journals  

    DOI: 10.3390/microorganisms11102385

  • Hyphal growth in Trichosporon asahii is accelerated by the addition of magnesium Reviewed International journal

    Keita Aoki, Kosuke Yamamoto, Moriya Ohkuma, Takashi Sugita, Naoto Tanaka, and Masako Takashima

    Microbiology Spectrum   2023.04

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  • Weizmannia acidilactici sp. nov., a lactic acid producing bacterium isolated from soils Reviewed International coauthorship International journal

    Vasana Tolieng, Naoto Tanaka, Yuh Shiwa, Sitanan Thitiprasert, Pawina Kanchanasin, Wongsakorn Phongsopitanun, Auttaporn Booncharoen, Nuttha Thongchul, Somboon Tanasupawat

    Syst Appl Microbiol   46 ( 1 )   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.syapm.2022.126389

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Books and Other Publications 【 display / non-display

  • 微生物資源の整備と利活用の戦略

    田中尚人( Role: Joint author ,  東京農業大学の乳酸菌コレクション)

    (株)エヌ・ティー・エス  2023.09  ( ISBN:978-4-86043-858-6

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    Language:Japanese   Book type:General book, introductory book for general audience

    生物資源として、生きた研究材料として重要性が高まる中、研究の発展に寄与する微生物資源の利活用について解説している。また、微生物メタゲノム情報の解析や環境サンプルの直接研究により明らかになりつつ微生物の多様性・生態について記載している。


Misc 【 display / non-display

  • 乳酸菌を分離するための基本 Invited Reviewed

    田中尚人

    日本乳酸菌学会誌   30 ( 1 )   3 - 7   2019.03

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ユーザーの求める機能性乳酸菌株のオンライン選抜システムの開発

    田中尚人,宮崎智,鈴木智典,冨田理,梶川揚申,内野昌孝,五十君靜信,岡田早苗

    日本微生物資源学会誌   33 ( 1 )   31 - 37   2017.06

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    Authorship:Lead author   Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

  • デルブレッキー菌は変な乳酸菌

    田中尚人

    生物工学会会誌   95 ( 4 )   207   2017.04

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

  • これからのハラール研究

    阿部尚樹、内野昌孝、野口治子、田中尚人、岡大貴

    食品機械装置   2016.05

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • ヒトの暮らしに貢献する乳酸菌 その3

    田中 尚人

    醤油の研究と技術   41 ( 5 )   317 - 320   2015.09

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher:一般財団法人日本醤油技術センター  

    乳酸菌の性質がヒトの生活にどのようにリンクしているか、代謝産物であればエコールやバニリンなどの酸化還元物質の影響、菌体であれば免疫調節作用が実際にどのように作用しているか概要を説明し、発酵については微生物間の生存競争のために必要な環境の酸性化が関わっているなどそれぞれ具体的な例を挙げながら微生物学的視点からの考察を加えて解説した。

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Past of Cooperative Research 【 display / non-display

  • 発酵食品由来微生物の分類学的研究

    2014.09 - 2017.03

    独立行政法人製品評価技術基盤機構  国内共同研究  Cooperative Research within Japan

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    国内外発酵食品由来乳酸菌の系統分布の解析および新種提唱

  • 新規機能性乳酸菌資源開発の共同事業

    2011.08 - 2014.03

    独立行政法人製品評価技術基盤機構  国内共同研究  Cooperative Research within Japan

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    モンゴルの乳酸菌の分離及び系統解析による系統的分布と応用利用のための性状解析

Presentations 【 display / non-display

  • Comparative genomics for reclassification of Stenotrophomonas maltophilia reference strains and biovar II group International conference

    2022.03 

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    Event date: 2022.03

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Characterization of biofilm formation and constituent bacterial species by addition of siderophores to environmental samples International conference

    2022.03 

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    Event date: 2022.03

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Analysis of mating-type loci of Cutaneotrichosporon cavernicola strains by comparative genomics International conference

    2022.03 

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    Event date: 2022.03

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Effects of biodegradable plastic on river microbiome International conference

    2019.03 

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    Event date: 2019.03

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Effects of bacterial community in the river water by degradation of bioplastic International conference

    2019.03 

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    Event date: 2019.03

    Language:Japanese   Presentation type:Oral presentation (general)  

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Committee Memberships 【 display / non-display

  • 日本微生物資源学会   理事(会計)  

    2014.09   

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    Committee type:Academic society

  • 日本微生物資源学会   理事(編集副委員長)  

    2009.04 - 2014.08   

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    Committee type:Academic society

  • 日本微生物系統分類研究会   理事(会計)  

    2008.01 - 2015.03