Papers - KUWAYAMA Takehito
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Severe maternal stress alters placental function, resulting in adipose tissue and liver dysfunction in offspring of mice Reviewed
Kondo R, Ozawa R, Satomi T, Funabayashi K, Iwata H, Kuwayama T, Shirasuna K.
Mol Cell Endocrinol 560 111814 2023
Language：English Publishing type：Research paper (scientific journal)
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PCR 法によるホロホロチョウ（Numida meleagris）の性判別 Reviewed
南村昌孝・石田和真・黒澤 亮・高橋幸水・白砂孔明・岩田尚孝・小川 博・桑山岳人
日本家禽学会誌 59 ( J1 ) J1 - J5 2022.04
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本家禽学会
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Acetoacetate is a trigger of NLRP3 inflammasome activation in bovine peripheral blood mononuclear cells Reviewed
Onizawa Y, Katoh T, Miura R, Konda K, Noguchi T, Iwata H, Kuwayama T, Hamano S, Shirasuna K.
Vet Immunol Immunopathol 244 110370 2022
Language：English
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NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice Reviewed International journal
Sano M, Komiyama H, Shinoda R, Ozawa R, Watanabe H, Karasawa T, Takahashi M, Torii Y, Iwata H, Kuwayama T, Shirasuna K.
Am J Reprod Immunol 87 e13527 2022
Language：English Publishing type：Research paper (scientific journal)
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HIKATA Kiho, MOROHASHI Nanaho, TARU Maho, SUZUKI Yusuke, NAKAMURA Tomoaki, TAKEDA Masahiro, KUWAYAMA Takehito, SHIRASUNA Koumei
Japanese Journal of Zoo and Wildlife Medicine 26 ( 4 ) 127 - 134 2021.12
Language：Japanese Publisher：Japanese Society of Zoo and Wildlife Medicine
<p>The southern tamandua (<i>Tamandua tetradactyla</i>), classified in the genus Tamandua, belongs to the clade Xenarthra, which includes other species like sloths and anteaters. The blood hormone during the gestation period for one individual of southern tamandua was determined; however, there have been no reports on the hormonal changes during multiple pregnancy period. Therefore, long-term blood sampling of the same female individual was performed, and plasma progesterone (P4) or estradiol (E2) during a total of 6 gestation periods was determined in the same male-female pair. From the results of plasma P4 concentration during all 6 gestation periods, the gestation period was estimated as 156.8 ± 1.7 days (152-164 days) long. The P4 concentration was 0.6 ± 0.1 ng/ml before the pregnancy period, 13.2 ± 1.8 ng/ml during early pregnancy, 28.1 ± 4.3 ng/ml during mid pregnancy, and 48.2 ± 11.8 ng/ml in late pregnancy. Plasma E2 concentration gradually increased from 100 days before the delivery until the day of delivery. The estrous cycle was estimated to be 45.5 ± 2.4 days (37-52 days) long. Thus, we demonstrated that the blood steroid hormone kinetics during multiple pregnancies of the same pair of southern tamanduas. The increase in P4 concentration was observed prior to the increase in E2 concentration during the early stage of the pregnancy, suggesting that early pregnancy determination is possible by detecting a continuous increase in P4 concentration in the southern tamandua.</p>
DOI： 10.5686/jjzwm.26.127
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Mitochondrial reactive oxygen species regulate mitochondrial biogenesis in porcine embryos
KAGEYAMA Mio, ITO Jun, SHIRASUNA Koumei, KUWAYAMA Takehito, IWATA Hisataka
Journal of Reproduction and Development 67 ( 2 ) 141 - 147 2021
Language：English Publisher：The Society for Reproduction and Development
<p> The number of mitochondria in blastocysts is a potential marker of embryo quality. However, the molecular mechanisms governing the mitochondrial number in embryos are unclear. This study was conducted to investigate the effect of reduced mitochondrial reactive oxygen species (ROS) levels on mitochondrial biogenesis in porcine embryos. Oocytes were collected from gilt ovaries and activated to generate over 4 cell-stage embryos at day 2 after activation. These embryos were cultured in media containing either 0.1 μM MitoTEMPOL (MitoT), 0.5 μM Mitoquinol (MitoQ), or vehicle (ethanol) for 5 days to determine the rate of development to the blastocyst stage. The mitochondrial number in blastocysts was evaluated by real-time polymerase chain reaction (PCR). Five days after activation, the embryos (early morula stage) were subjected to immunostaining to determine the expression levels of NRF2 in the nucleus. In addition, the expression levels of <i>PGC1α</i> and <i>TFAM</i> in the embryos were examined by reverse transcription PCR. One day of incubation with the antioxidants reduced the ROS content in the embryos but did not affect the rate of development to the blastocyst stage. Blastocysts developed in medium containing MitoT had lower mitochondrial DNA copy numbers and ATP content, whereas MitoQ showed similar but insignificantly trends. Treatment of embryos with either MitoT or MitoQ decreased the expression levels of NRF2 in the nucleus and levels of <i>PGC1α</i> and <i>TFAM</i>. These findings indicate that reductions in mitochondrial ROS levels are associated with low mitochondrial biogenesis in embryos.</p>
DOI： 10.1262/jrd.2020-111
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HIRATA Yoshiki, KATSUKURA Yusuke, HENMI Yuka, OZAWA Ren, SHIMAZAKI Sayaka, KUROSAWA Akira, TORII Yasushi, TAKAHASHI Hironori, IWATA Hisataka, KUWAYAMA Takehito, SHIRASUNA Koumei
Journal of Reproduction and Development 67 ( 4 ) 257 - 264 2021
Language：English Publisher：The Society for Reproduction and Development
<p> Advanced maternal age is a risk factor for female infertility, and placental dysfunction is considered one of the causes of pregnancy complications. We investigated the effects of advanced maternal aging on pregnancy outcomes and placental senescence. Female pregnant mice were separated into three groups: young (3 months old), middle (8–9 months old), and aged (11–13 months old). Although the body weights of young and middle dams gradually increased during pregnancy, the body weight of aged dams only increased slightly. The placental weight and resorption rate were significantly higher, and live fetal weights were reduced in a maternal age-dependent manner. Although mRNA expression of senescence regulatory factors (p16 and p21) increased in the spleen of aged dams, mRNA expression of p16 did not change and that of p21 was reduced in the placenta of aged dams. Using a cytokine array of proteins extracted from placental tissues, the expression of various types of senescence-associated secretory phenotype (SASP) factors was decreased in aged dams compared with young and middle dams. The aged maternal placenta showed reduced immune cell accumulation compared with the young placenta. Our present results suggest that models using pregnant mice older than 8 months are more suitable for verifying older human pregnancies. These findings suggest that general cellular senescence programs may not be included in the placenta and that placental functions, including SASP production and immune cell accumulation, gradually decrease in a maternal age-dependent manner, resulting in a higher rate of pregnancy complications.</p>
DOI： 10.1262/jrd.2021-034
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Uncaria tomentosa extract (AC-11) improves pregnancy hypertension together with suppression of sFlt-1 and sEng Reviewed
26 127 - 132 2021
Language：English Publishing type：Research paper (scientific journal)
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β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption Reviewed International journal
Hirata Y, Shimazaki S, Suzuki S, Henmi Y, Komiyama H, Kuwayama T, Iwata H, Karasawa T, Takahashi M, Takahashi H, Shirasuna K.
J Reprod Immunol 148 103433 2021
Language：English Publishing type：Research paper (scientific journal)
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Mitochondrial reactive oxygen species regulate mitochondrial biogenesis in porcine embryos Reviewed
Kageyama M, Ito J, Shirasuna K, Kuwayama T, Iwata H.
J Reprod Dev 67 141 - 147 2021
Language：English Publishing type：Research paper (scientific journal)
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IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2 Reviewed
Nakamura Y, Aihara R, Iwata H, Kuwayama T, Shirasuna K.
Am J Reprod Immunol 85 e13365 2021
Language：English
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MOROHASHI Nanaho, SANO Michiya, KATO Kosuke, TOYODA Hideto, NAKAMURA Tomoaki, TAKEDA Masahiro, KUWAYAMA Takehito, SHIRASUNA Koumei
Japanese Journal of Zoo and Wildlife Medicine 25 ( 4 ) 119 - 127 2020.12
Language：Japanese Publisher：Japanese Society of Zoo and Wildlife Medicine
<p> Capybara (<i>Hydrochoerus hydrochaeris</i>) is the biggest rodent in the world which lives in South America and well-known at Japanese zoos. Because the placental structure of capybara is similar to human placenta, the use of capybara as an experimental animal is also being considered. It is essential to understand the reproductive physiology of capybara for the planned breeding. However, there are few information about the reproductive physiology of capybara. In the present study, we tried to establish the method of blood sample collection and vaginal smear inspection using husbandary training (no anesthesia and retention). Then, the steroid hormone concentration in plasma and feces was examined to identify the estrous cycle and pregnancy in capybara. Plasma or fecal samples were collected from non-pregnant and pregnant capybaras and steroid hormones were determined by ELISA. In non-pregnant individuals, changes in blood progesterone (P<sub>4</sub>) and estrone-3-sulfate (E<sub>1</sub>S) concentrations showed clear estrous cycle-like changes for 3 cycles (average 11.7 ± 0.9 days). Change in blood E<sub>1</sub>S concentration were consistent with change in fecal estradiol (E<sub>2</sub>) and appearance of anucleated keratinized epithelial cells in vaginal smear inspection. Fecal E<sub>2</sub> concentrations of non-pregnancy capybara also changed like the estrous cycle. In fecal samples of pregnant capybara, the concentration of P<sub>4</sub> were higher than that in the non-pregnant capybara. Fecal P<sub>4</sub> and E<sub>2</sub> concentrations were higher during pregnancy and gradually reduced after parturition. These results suggest that the estrous cycle in capybara may be identified by determining plasma P<sub>4</sub>, E<sub>1</sub>S and fecal E<sub>2</sub> concentrations and vaginal smear inspection, and pregnancy of capybara can be predicted by measuring the P<sub>4</sub> concentration in feces.</p>
DOI： 10.5686/jjzwm.25.119
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SANO Michiya, SHIMAZAKI Sayaka, KANEKO Yasuaki, KARASAWA Tadayoshi, TAKAHASHI Masafumi, OHKUCHI Akihide, TAKAHASHI Hironori, KUROSAWA Akira, TORII Yasushi, IWATA Hisataka, KUWAYAMA Takehito, SHIRASUNA Koumei
Journal of Reproduction and Development 66 ( 3 ) 241 - 248 2020
Language：English Publisher：The Society for Reproduction and Development
<p> Maternal obesity is one of the major risk factors for pregnancy complications and is associated with low-grade chronic systemic inflammation due to higher levels of pro-inflammatory cytokines such as interleukin (IL)-1β. Pregnant women with obesity have abnormal lipid profiles, characterized by higher levels of free fatty acids, especially palmitic acid (PA). Previously, we reported that PA stimulated IL-1β secretion via activation of NLRP3 inflammasome in human placental cells. These observations led us to hypothesize that higher levels of PA induce NLRP3 inflammasome activation and placental inflammation, resulting in pregnancy complications. However, the effects of PA on NLRP3 inflammasome during pregnancy <i>in vivo</i> remain unclear. Therefore, PA solutions were administered intravenously into pregnant mice on day 12 of gestation. Maternal body weight was significantly decreased and absorption rates were significantly higher in PA-injected mice. The administration of PA significantly increased IL-1β protein and the mRNA expression of NLRP3 inflammasome components (<i>NLRP3</i>, <i>ASC</i>, and caspase-1) within the placenta. In murine placental cell culture, PA significantly stimulated IL-1β secretion, and this secretion was suppressed by a specific NLRP3 inhibitor (MCC950). Simultaneously, the number of macrophages/monocytes and neutrophils, together with the mRNA expression of these chemokines increased significantly in the placentas of PA-treated mice. Treatment with PA induced ASC assembling and IL-1β secretion in macrophages, and this PA-induced IL-1β secretion was significantly suppressed in NLRP3-knockdown macrophages. These results indicate that transient higher levels of PA exposure in pregnant mice activates NLRP3 inflammasome and induces placental inflammation, resulting in the incidence of absorption.</p>
DOI： 10.1262/jrd.2020-007
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KOBAYASHI Mitsuru, ITO Jun, SHIRASUNA Koumei, KUWAYAMA Takehito, IWATA Hisataka
Journal of Reproduction and Development 66 ( 6 ) 539 - 546 2020
Language：English Publisher：The Society for Reproduction and Development
<p> We examined the effect of ploidy on mitochondrial DNA (mtDNA) copy number in embryos and the amount of cell-free mitochondrial and nucleic DNA content (cf-mtDNA and cf-nDNA) in spent culture medium (SCM). Oocytes collected from the ovaries were matured, activated, incubated in medium containing cycloheximide (CHX) or CHX and cytochalasin B (CB) for 4.5 h to produce haploid or diploid embryos (H-group and D-group embryos). These embryos were cultured for 7 days, and the blastocysts and SCM were examined. The amount of mtDNA and nDNA was determined by real-time PCR. The rate of development to the blastocyst stage was higher for the D-group than for the H-group. Moreover, D-group blastocysts had less mtDNA compared to the H-group blastocysts. After activation, the mitochondrial content was constant before the blastocyst stage in D-group embryos, but increased earlier in H-group embryos. The amount of cf-mtDNA in the SCM of D-group blastocysts was greater than that of H-group blastocysts. However, when the cf-mtDNA in the SCM of 2 cell-stage embryos (day 2 post-activation) was examined, the amount of cf-mtDNA was greater in the H-group than in the D-group embryos. When D-group embryos were cultured for 7 days, a significant correlation was observed between the total cell number of blastocysts and cf-nDNA content in the SCM. Hence, although careful consideration is needed regarding the time point for evaluating mtDNA content in the embryos and SCM, this study demonstrates that mtDNA in the embryos and SCM was affected by the ploidy of the embryos.</p>
DOI： 10.1262/jrd.2020-097
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Interferon tau regulates cytokine production and cellular function in human trophoblast cell line. Reviewed
Tanikawa N, Seno K, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K
J Interferon & Cytokine Research 37 456 - 466 2017.10
Language：English Publishing type：Research paper (scientific journal)
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Advanced glycation end products and lipopolysaccharide stimulate interleukin-6 secretion via RAGE/TLR4-NF-kB-ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages.
Ohtsu A, Shibutani Y, Seno K, Iwata H, Kuwayama T, Shirasuna K.
Experimental and Therapeutic Medicine 14 4364 - 4370 2017.08
Language：English Publishing type：Research paper (scientific journal)
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Age-associated mRNA expression changes in bovine endometrial cells in vitro. Reviewed
Tanikawa N, Ohtsu A, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K
Reprod Biol Endocrinol 63 2017.08
Language：English Publishing type：Research paper (scientific journal)
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Advanced glycation end products regulate interleukin-1β production in human placenta. Reviewed
Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
J Reprod Dev 63 401 - 408 2017.05
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid stimulates interleukin-8 via the TLR4/NF-kB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells. Reviewed
Ohtsu A, Tanaka H, Seno K, Iwata H, Kuwayama T, Shirasuna K.
Am J Reprod Immunol 77 2017.02
Language：English Publishing type：Research paper (scientific journal)
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Promotion of glucose utilization by insulin enhances granulosa cell proliferation and developmental competence of porcine oocyte growth in vitro. Reviewed
Itami N, Munakata Y, Shirasuna K, Kuwayama T, Iwata H
Zygote 25 65 - 74 2016.12
Language：English Publishing type：Research paper (scientific journal)
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Low oxygen level increases proliferation and metabolic changes in bovine granulosa cells. Reviewed
Shiratsuki S, Hara T, Munakata Y, Shirasuna K, Kuwayama T, Iwata H.
Mol Cell Endocrinol. 437 75 - 85 2016.12
Language：English Publishing type：Research paper (scientific journal)
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Relationship between the number of cells surrounding oocytes and energy states of oocytes. Reviewed
Munakata Y, Ichinose T, Ogawa K, Itami N, Tasaki H, Shirasuna K, Kuwayama T, Iwata H.
Theriogenology. 86 ( 7 ) 1789 - 1798 2016.10
Language：English Publishing type：Research paper (scientific journal)
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Addition of granulosa cell mass to the culture medium of oocytes derived from early antral follicles increases oocyte growth, ATP content, and acetylation of H4K12. Reviewed
Sugiyama M1, Sumiya M1, Shirasuna K1, Kuwayama T1, Iwata H1.
Zygote. 2016.10
Language：English Publishing type：Research paper (scientific journal)
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Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. Reviewed
Tanaka H, Ohtsu A, Shiratsuki S, Kawahara-Miki R, Iwata H, Kuwayama T, Shirasuna K.
Mol Reprod Dev. 83 ( 9 ) 815 - 826 2016.09
Language：English Publishing type：Research paper (scientific journal)
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Gene expression patterns in granulosa cells and oocytes at various stages of follicle development as well as in in vitro grown oocyte-and-granulosa cell complexes. Reviewed
Munakata Y, Kawahara-Miki R, Shiratsuki S, Tasaki H, Itami N, Shirasuna K, Kuwayama T, Iwata H.
J Reprod Dev. 64 ( 4 ) 359 - 366 2016.08
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. Reviewed
Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
J Reprod Immunol. 116 104 - 112 2016.08
Language：English Publishing type：Research paper (scientific journal)
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Liver condition of Holstein cows affects mitochondrial function and fertilization ability of oocytes. Reviewed
Tanaka H, Takeo S, Abe T, Kin A, Shirasuna K, Kuwayama T, Iwata H.
J Reprod Dev. 62 ( 3 ) 235 - 240 2016.06
Language：English Publishing type：Research paper (scientific journal)
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AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. Reviewed
Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
Am J Reprod Immunol. 75 ( 5 ) 557 - 568 2016.05
Language：English Publishing type：Research paper (scientific journal)
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Age-associated deterioration in follicular fluid induces a decline in bovine oocyte quality. Reviewed
Takeo S, Kimura K, Shirasuna K, Kuwayama T, Iwata H.
Reprod Fertil Dev. 2016.02
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1071/RD15228.
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AGEs and HMGB1 increase inflammatory cytokine production from human placental cells, resulting in an enhancement of monocyte migration.
AGEs and HMGB1 increase inflammatory cytokine production from human placental cells, resulting in an enhancement of monocyte migration.
AGEs and HMGB1 increase inflammatory cytokine production from human placental cells, resulting in an enhancement of monocyte migration. 75 557 - 568 2016
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. Reviewed
Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
J Reprod Immunol 116 104 - 112 2016
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. Reviewed
Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
J Reprod Immunol 116 104 - 112 2016
Language：English Publishing type：Research paper (scientific journal)
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Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells. Reviewed
Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
J Reprod Immunol 116 104 - 112 2016
Language：English Publishing type：Research paper (scientific journal)
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Moderate Hypoxia Down-Regulates Interleukin-6 Secretion and TLR4 Expression in Human Sw.71 Placental Cells.
Shirasuna K.a · Shimamura N.a · Seno K.a · Ohtsu A.a Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T
Cell Physiol Biochem. 36 ( 6 ) 2149 - 2160 2015.07
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1159/000430181
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Mitochondrial biogenesis and degradation are induced by CCCP treatment of porcine oocytes. Reviewed
Itami N, Shiratsuki S, Shirasuna K, Kuwayama T, Iwata H
Reproduction 150 ( 2 ) 97 - 104 2015.05
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1530/REP-15-0037.
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Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin 1 activation Reviewed
N. Itami, K. Shirasuna, T. Kuwayama, H. Iwata
Theriogenology 83 ( 8 ) 1360 - 1367 2015.05
Language：English Publishing type：Research paper (scientific journal)
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Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows Reviewed
Sugiyama M, Kawahara-Miki R, Kawana H, Shirasuna K, Kuwayama T, Iwata H.
J Reprod Dev 2015.04
Language：English Publishing type：Research paper (scientific journal)
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Effect of 5-aminoimidazole-4-carboxamide ribonucleoside on the mitochondrial function and developmental ability of bovine oocytes. Reviewed
Takeo S, Abe T, Shirasuna K, Kuwayama T, Iwata H
Theriogenology 84 ( 4 ) 490 - 497 2015.03
Language：English Publishing type：Research paper (scientific journal)
DOI： doi: 10.1016/j.
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Effects of reaggregated granulosa cells and oocytes derived from early antral follicles on the properties of oocytes grown in vitro Reviewed
Oi A, Tasaki H, Munakata Y, Shirasuna K, Kuwayama T, Iwata H.
J Reprod Dev 2015.02
Language：English Publishing type：Research paper (scientific journal)
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培養皿の形状がウシ初期胞状卵胞由来卵子の体外発育及び発生能に及ぼす影響 Reviewed
川名宏典, 松本美保, 門司恭典, 桑山岳人, 岩田尚孝
日本胚移植学雑誌 36 ( 2 ) 65 - 70 2015.01
Language：Japanese Publishing type：Research paper (scientific journal)
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Age-associated changes in bovine oocytes and granulosa cell complexes collected from early antral follicles. Reviewed
N. Itami, R. Kawahara-Miki, H. Kawana, M. Endo, T. Kuwayama, H. Iwata
Journal of Assisted Reproduction and Genetics 31 ( 8 ) 1079 - 1088 2014.08
Language：English Publishing type：Research paper (scientific journal)
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Resveratrol improves the mitochondrial function and fertilization outcome of bovine oocytes. Reviewed
Takeo S, Sato D, Kimura K, Monji Y, Kuwayama T, Kawahara-Miki R, Iwata H.
J Reprod Dev. 60 ( 2 ) 92 - 96 2014.04
Language：English Publishing type：Research paper (scientific journal)
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Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes. Reviewed
Sato D, Itami N, Tasaki H, Takeo S, Kuwayama T, Iwata H.
PLoS One 9 ( 4 ) 2014.04
Language：English Publishing type：Research paper (scientific journal)
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Maternal liver damage delays meiotic resumption in bovine oocytes through impairment of signalling cascades originated from low p38MAPK activity in cumulus cells. Reviewed
Tanaka H, Takeo S, Monji Y, Kuwayama T, Iwata H.
Reprod Domest Anim 49 ( 1 ) 101 - 108 2014.02
Language：English Publishing type：Research paper (scientific journal)
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Differential roles of hypothalamic serotonin receptor subtypes in the regulation of prolactin secretion in the turkey hen. Reviewed
Bakken T, Kang SW, Kosonsiriluk S, Kuwayama T, Chaiseha Y, El Halawani ME
Acta Histochem 116 ( 1 ) 131 - 137 2014.01
Language：English Publishing type：Research paper (scientific journal)
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Supplementation of Maturation Medium with Folic Acid Affects DNA methylation of Porcine Oocytes and Histone Acethylation of Early Developmental Stage Embryos. Reviewed
Sato D, Sakurai K, Monji Y, Kuwayama T, Iwata H.
J Mamm Ova.Res 30 109 - 116 2013.12
Language：English Publishing type：Research paper (scientific journal)
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Effect of maternal age on the ratio of cleavage and mitochondrial DNA copy number in early developmental stage bovine embryos. Reviewed
Takeo S, Goto H, Kuwayama T, Monji Y, Iwata H.
J Reprod Dev 59 ( 2 ) 174 - 179 2013.12
Language：English Publishing type：Research paper (scientific journal)
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Effect of bovine age on the proliferative activity, global DNA methylation, relative telomere length and telomerase activity of granulosa cells. Reviewed
Goto H, Iwata H, Takeo S, Nisinosono K, Murakami S, Monji Y, Kuwayama T.
Zygote Epub ahead of print 2013.08
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Next-generation sequencing reveals genomic features in the Japanese quail. Reviewed
Kawahara-Miki R1, Sano S, Nunome M, Shimmura T, Kuwayama T, Takahashi S, Kawashima T, Matsuda Y, Yoshimura T, Kono T.
Genomics. 101 345 - 353 2013.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Estradiol supports in vitro development of bovine early antral follicles. Reviewed
Endo M, Kawahara-Miki R, Cao F, Kimura K, Kuwayama T, Monji Y, Iwata H.
Reproduction 145 ( 1 ) 85 - 96 2013.01
Language：English Publishing type：Research paper (scientific journal)
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Age-associated changes in gene expression and developmental competence of bovine oocytes, and a possible countermeasure against age-associated events. Reviewed
Takeo S, Kawahara-Miki R, Goto H, Cao F, Kimura K, Monji Y, Kuwayama T, Iwata H.
Mol Reprod Dev 80 ( 7 ) 508 - 521 2013.01
Language：English Publishing type：Research paper (scientific journal)
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Estradiol has a major role in antrum formation of porcine preantral follicles cultured in vitro. Reviewed
Tasaki H, Iwata H, Sato D, Monji Y, Kuwayama T.
Theriogenology 79 ( 5 ) 809 - 914 2013.01
Language：English Publishing type：Research paper (scientific journal)
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Liver condition affects bovine oocyte qualities by changing the characteristics of follicular fluid and plasma. Reviewed
Tanaka H, Shibano K, Monji Y, Kuwayama T, Iwata H.
Reprod Domest Anim 48 ( 4 ) 619 - 626 2013.01
Language：English Publishing type：Research paper (scientific journal)
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Effect of estradiol during culture of bovine oocyte-granulosa cell complexes on the mitochondrial DNA copies of oocytes and telomere length of granulosa cells. Reviewed
Endo M, Kimura K, Kuwayama T, Monji Y, Iwata H.
Zygote 12 1 - 9 2012.12
Language：English Publishing type：Research paper (scientific journal)
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Differential Attachment of Bovine Y Chromosome-bearing Sperm to the Zona Pellucida. Reviewed
Sakaguchi Y, Sejiyama Y, Kato S, Iwata H, Monji Y, Kuwayama T.
Mamm. Ova. Res. 29 55 - 59 2012.05
Language：English Publishing type：Research paper (scientific journal)
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Effect of bovine age on the proliferative activity, global DNA methylation, relative telomere length and telomerase activity of granulosa cells. Reviewed
Goto H1, Iwata H, Takeo S, Nisinosono K, Murakami S, Monji Y, Kuwayama T.
Zygote 21 ( 3 ) 256 - 264 2011.07
Language：English Publishing type：Research paper (scientific journal)
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Effect of maternal age on mitochondrial DNA copy number, ATP content and IVF outcome of bovine oocytes. Reviewed
Iwata H, Goto H, Tanaka H, Sakaguchi Y, Kimura K, Kuwayama T, Monji Y.
Reprod Fertil Dev. 23 ( 3 ) 424 - 432 2011.02
Language：English Publishing type：Research paper (scientific journal)
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Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. Reviewed
Shiratsuki S, Iwata H, Kimura K, Kuge T, Monji Y, Kuwayama T.
Theriogenology 75 ( 5 ) 841 - 848 2010.12
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Changes in the Sperm-zona Pellucida Binding Properties during Porcine Oocyte Maturation. Reviewed
Sakaguchi Y, Uzuhashi R, Iwata H, Monji Y, Kuwayama T.
J Mamm Ova Res 27 130 - 135 2010.12
Language：English Publishing type：Research paper (scientific journal)
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Follicle growth and oocyte developmental competence in cows with liver damage. Reviewed
Iwata H, Tanaka H, Kanke T, Sakaguchi Y, Shibano K, Kuwayama T, Monji Y.
Reprod Domest Anim. 45 ( 5 ) 888 - 895 2010.10
Language：English Publishing type：Research paper (scientific journal)
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Effect of maternal age on the developmental competence and progression of nuclear maturation in bovine oocytes. Reviewed
Yamamoto T, Iwata H, Goto H, Shiratuki S, Tanaka H, Monji Y, Kuwayama T.
Mol Reprod Dev. 77 ( 7 ) 595 - 604 2010.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Effect of N-acetyl-D-glucosamine on bovine sperm-oocyte interactions. Reviewed
Sakaguchi Y, Iwata H, Kuwayama T, Monji Y.
J Reprod Dev. 55 ( 6 ) 676 - 684 2009.10
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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ブタ着床前期胚の体外培養 - 受精後12日目のブタ胚の体外培養方法確率の試み -
佐々木康仁, 岩田尚孝, 門司恭典, 桑山岳人
日本胚移植学雑誌 2009.09
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
ブタの受精後12日目の胚の体外培養には血清とBSAさらにはアミノ酸の添加が効果的であることを示した。
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凍結希釈液へのイクラ由来の脂質の添加が豚精子の性状に及ぼす影響
斉藤孝太, 水野宏亮, 岩田尚孝, 桑山岳人, 門司恭典
日本胚移植学雑誌 2009.09
Language：Japanese Publishing type：Research paper (scientific journal)
イクラ由来の脂質の凍結希釈液への添加は豚精子の低温耐性を向上させることを示した。
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Effect of carbohydrates on the ability of bull sperm to bind to bovine oviduct epithelial cells
Kon Y, Iwata H, Shiono H, Matsubara K, Kurita A, Sakaguchi Y, Kuwayama T, Monji Y.
Reprod. Domest. Anim. 2009.06
Language：English Publishing type：Research paper (scientific journal)
ＮアセチルＤグルコサミンは精子の卵管上皮への結合性をによって昂進させるが精子の生存時間の延長に貢献しないことを示した。
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Effects of follicular fluids on the growth of porcine preantral follicle and oocyte. Reviewed
Metoki T, Iwata H, Itoh M, Kasai M, Takajyo A, Suzuki A, Kuwayama T, Monji Y.
Zygote 16 ( 3 ) 239 - 247 2008.06
Language：English Publishing type：Research paper (scientific journal)
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ブタにおける精子処理および共培養時間が透明帯接着精子を有する精子比率に及ぼす影響
塩野紘，岩田尚孝。斎藤孝太，浦川真明，栗田敦史，今義拓，佐々木康仁，桑山岳人，門司恭典
日本胚移植学雑誌 2008.06
Language：Japanese Publishing type：Research paper (scientific journal)
ブタにおける精子の透明帯への接着性は，最初はY-精子においてやや高く，精子の経時的な培養時間においてこの優位性が縮小する事が示唆された。
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形態から卵巣萎縮と推定されたウシの卵胞発育状態
中村光子，栗田敦史，増田恵，岩田尚孝，桑山岳人，門司恭典
日本胚移植学雑誌 2008.06
Language：Japanese Publishing type：Research paper (scientific journal)
ウシにおいても卵巣機能が低下すると卵巣萎縮を引き起こし，すべての発育ステージの卵胞が減少していること，そしてその所見も正常ウシと異なることが示された。
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Effects of modification of in vitro fertilization techniques on the sex ratio of the resultant bovine embryos
Iwata H, Shiono H, Kon Y, Matsubara K, Kimura K, Kuwayama T, Monji Y.
Anim. Reprod. Sci. 2008.03
Language：English Publishing type：Research paper (scientific journal)
卵丘細胞に対する精子の曝露が試験管培養によって生み出される雄胚の比率を上昇させることを示した。
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雄ニホンウズラの採血に対するコルチコステロン分泌反応
伊藤愛弓，園田将晴，岩田尚孝，門司恭典，桑山岳人
関東畜産学会報 2007.10
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
雄ニホンウズラにおいて採血はストレスとなるがストレス状態は採血の開始から30分後には消失することを示した。
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メチルアセトアミドを耐凍剤に用いたニワトリ凍結精液による人工授精後の受精率の推移
北園大志，伊藤哲，金子佳恵，岩田尚孝，門司恭典，桑山岳人
関東畜産学会報 2007.10
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
メチルアセトアミドを耐凍剤に用いてニワトリ凍結精液を作製した場合，凍結精液の融解後急激に精子の運動性が低下することが明らかとなった。
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Analysis of mtDNA sequences shows Japanese native chickens have multiple origins
Oka T, 他10名
Anim. Genet. 2007.06
Language：English Publishing type：Research paper (scientific journal)
日本鶏が複数の起源を持っていることをmtDNA配列の分析により明らかにした。
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Effect of follicular fluid collected from various diameter follicles on the progression of nuclear maturation and developmental competence of pig oocytes
Ito M, Iwata H, Kitagawa M, Kon Y, Kuwayama T, Monji Y.
Anim. Reprod. Sci. 2007.06
Language：English Publishing type：Research paper (scientific journal)
ブタの大卵胞液中存在す30から100kDaの分子量わずかなのタンパク質が核成熟の進行と卵母細胞の発達を向上させることを示した。
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Effects of modification of in vitro fertilization techniques on the sex ratio of the resultant bovine embryos. Reviewed
Iwata H, Shiono H, Kon Y, Matsubara K, Kimura K, Kuwayama T, Monji Y.
Anim Reprod Sci. 105 234 - 244 2007.03
Language：English Publishing type：Research paper (scientific journal)
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The effect of glucose on the progression of the nuclear maturation of pig oocytes
Sato H, Iwata H, Hayashi T, Kimura K, Kuwayama T, Monji Y.
Anim. Reprod. Sci. 2007.01
Language：English Publishing type：Research paper (scientific journal)
ブタ卵母細胞の核成熟過程におけるグルコースの役割を示した。
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Effect of modification of ovary preservation solution by adding glucose on the maturation and development of pig oocytes after prolonged storage.
Sakamoto A、Iwata H、Sato H、Hayashi T、Monji Y
J.Reprod.Dev. 2006.11
Language：English Publishing type：Research paper (scientific journal)
ブタ卵子の保存液へのグルコースの添加は卵母細胞の成熟率を向上させることを示した。
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The genetic variability and relationships of Japanese and foreign chickens assessed by microsatellite DNA profiling
S A M Osman, 他9名
Asian-Aust.J.Anim.Sci. 2006.10
Language：English Publishing type：Research paper (scientific journal)
マイクロサテライトDNA多型に基づき日本鶏の4つのクラスに分類し，その結果がこれまでの体形態学に基づく分類とほとんど一致する事を示した。
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Induction of estrus by prostaglandin F2α administration in the vaginal vestibules of miniature pigs
Kuge T、Iwata H、Domeki I、Shioya Y、Monji Y
J.Reprod.Dev. 2006.06
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
ミニチュアブタの膣前庭粘膜下にPGF2αを1.5mg2回投与することで，早期に黄体を退行させ，発情を誘起することが出来ることを示した。
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岐阜地鶏抱卵鶏の血漿コルチコステロン濃度：産卵鶏および休産鶏との比較
有村君子
日本家禽学会誌 2006.05
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
抱卵期の鶏の血漿コルチコステロン濃度が、産卵期および休産期の鶏よりも高い値を示すことを明らかにした。また、明期において明期の終りに近い時間の血漿コルチコステロン濃度が低い値を示すことを明らかにした。
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産卵、抱卵、育雛中の岐阜地鶏における血漿コルチコステロン濃度
飯田真希,山本茜,岩田尚孝,門司恭典,桑山岳人
関東畜産学会報 2006.03
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
岐阜地鶏の抱卵期は産卵期や育雛期よりも高いストレス状態にあるものと推察した。
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Inhibitory effects of calcium ionophore pretreatment of porcine oocytes on polyspermic fertilization
Hayashi T, Sato H, Iwata H, Kuwayama T, Monji Y.
Zygote 2006.02
Language：English Publishing type：Research paper (scientific journal)
ブタ卵子をカルシウイオノフォア処理することで多精子受精を防げることを示した
-
Comparison between the characteristics of follicular fluid and the developmental competence of bovine oocytes
Iwata H、Inoue J、Kimura K、Kuge T、Monji Y
Anim.Reprod.Sci. 2006.01
Language：English Publishing type：Research paper (scientific journal)
卵巣内の卵子の発生能力や受精能力と卵胞液中の黄疸指数や尿素態窒素含量と大きな相関があることを示した。
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Genetic variability and relationships of native Japanese chickens based on microsatellite DNA polymorphisms-focusing on the natural monuments of Japan
Osman SA-B、Sekino M、Kinoshita、Nishibori M、Yamamoto Y、Tsudzuki M
J.Poult.Sci. 2006.01
Language：English Publishing type：Research paper (scientific journal)
マイクロサテライトDNA多型に基づき天然記念物の日本鶏の遺伝的多様性を示した。
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Corticosterone secretion as a response of incubating Gifujidori hens to restraint stress
Arimura K
J.Poult.Sci. 2006.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
抱卵鶏のストレス状態がストレスを与える前もストレスを与えた後も産卵鶏や休産鶏より高いことを示した。
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Modification of ovary stock solution with magnesium and raffinose improved the developmental competence of oocytes after long preservation
Iwata H、Hayashi T、Sato H、Kimura K、Monji Y
Zygote 2005.11
Language：English Publishing type：Research paper (scientific journal)
ウシ卵巣保存液へのラフィノースやマグネシウムの添加が卵子の発生能力の保持に有効であることを示した。
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ミニチュアブタの黄体開花期におけるプロスタグランジンF2α連続投与が血中性ステロイドホルモン濃度および腟内生理諸性状に及ぼす影響
久下壮、岩田尚孝、門司恭典
東京農大農学集報 2005.09
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
ミニチュアブタにおいてPGF2α投与により発情期を短縮させる事が可能である事を示した。
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ニワトリの放卵前後の血漿コルチコステロン濃度
有村君子、田中克英
東京農大農学集報 2005.09
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
ニワトリの放卵前後の血漿コルチコステロン濃度を明らかにし、放卵が一過性のストレッサーとなる事を示唆した。
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ニホンウズラ雄の血漿テストステロン濃度の日内変動
田中克英
東京農大農学集報 2005.09
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
ニホンウズラ雄の血漿テストステロン濃度の日内変動を明らかにした。
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岐阜地鶏における抱卵中絶処理直後のプロラクチン、黄体形成ホルモンおよびエストラジオール-17βの分泌
勝又瑞穂、岩澤淳
日本家禽学会誌 2005.08
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
抱卵開始後3日で抱卵を中絶した場合と21日で中絶した場合とでは抱卵中絶直後の血漿PRL、LHおよびE2レベルに違いがある事を示した。
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ニホンウズラにおける排卵時間と卵の卵管内滞留時間
桑山岳人，小川博，田中克英
東京農業大学農学集報 2005.06
Authorship：Lead author Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
ニホンウズラにおける排卵時間と卵の卵管内滞留時間を示した。
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岐阜地鶏における抱卵中絶後の血漿プロラクチン、黄体形成ホルモン、卵胞刺激ホルモン及びエストラジオール濃度の推移
勝又瑞穂、岩澤淳
日本家禽学会誌 2005.05
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
抱卵行動を中絶させると卵巣機能が速やかに回復の方向に向かうことを内分泌学的に示した。
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Changes in the plasma corticosterone concentration under restraint stress in Gifujidori roosters at different ages.
桑山 岳人
Jour.Agri.Sci. Tokyo Univ of Agri 2004.12
Language：English Publishing type：Research paper (scientific journal)
若齢と老齢のニワトリに緊縛ストレスを与えたところ若齢の方がストレスに敏感であること、またそのストレスに対する抵抗性が週齢によって異なることが示唆された。
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Changes in calcium, magnesium and phosphorus contents of eggshell during stay in oviduct uterus in the guineafoul and chicken
Ogawa H、Uehara M、Kawashima M、Tanaka K
J.Poult.Sci. 2004.07
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウとニワトリの卵管子宮部滞留中の卵殻中のカルシウム，マグネシウムおよびリンの変動を示した。
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ミニチュアブタにおけるプロスタグランジンF2αを用いた発情同期化法の検討
久下壮、井上真光、百目鬼郁男、門司恭典
日本養豚学会誌 2004.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
性腺刺激ホルモンとプロスタグランジンF2αの併用投与により発情同期化への応用が可能であることを示唆した。
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Effect of GnRH (buserelin) administration 12 days after artificial insemination on the pregnancy rates of cattle
Monji Y、Sato M、 Domeki I
Jour.Agri.Sci. Tokyo Univ of Agri 2003.09
Language：English Publishing type：Research paper (scientific journal)
牛において人工授精12日目のブセレリン投与は，受胎率を向上させることを示唆した。
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岐阜地鶏雄に対する明期における緊縛ストレスが血漿コルチコステロン濃度に及ぼす影響
有村君子、門司恭典、百目鬼郁男、田中克英
東京農大農学集報 2003.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
岐阜地鶏雄の血漿コルチコステロン濃度は明期開始後に高いこと，またストレス反応は暗期開始前に高くなることを明らかにした。
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抱卵岐阜地鶏の卵巣機能に及ぼす絶食処理の影響
勝又瑞穂、門司恭典、百目鬼郁男、田中克英
東京農大農学集報 2003.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
抱卵中の岐阜地鶏の絶食処理を実施し、抱卵行動が中止した個体は、絶食処理終了後血漿エストラジオール濃度が急激に示した上昇することを示した。
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マイクロプレートを用いた雄シバヤギの血漿中テストステロンの酵素免疫測定法の検討
金子悦史、門司恭典、神戸側明、百目鬼郁男
東京農大農学集報 2003.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
雄シバヤギの血漿中テストステロンが酵素免疫測定法で測定可能となった。
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ミニチュアブタにおける血漿中コルチゾールの酵素免疫測定法
金子悦史、菅原豊、門司恭典、神戸側明、百目鬼郁男
日本養豚学会誌 2003.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
酵素免疫測定法によってミニチュアブタにおける血漿中コルチゾール濃度の測定に応用し得ることが明らかとなった。
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Reproductive ability of Ceylon jungle fowls (Gallus lafayettei) after imported in Japan
Ichinoe K
東京農大農学集報 2003.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
セイロン野鶏と岐阜地鶏との間にF1およびF2が作出出きることを示した。
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Presence of calcitonin receptors in shell gland of the guinea fowl and changes in binding property during an oviposition cycle
Ogawa H、Takahashi T、Kawashima M
Poultry Sci. 2003.01
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウ卵管子宮部におけるカルシトニンレセプターの存在とカルシトニンレセプターの放卵サイクル中の結合能の推移を示した。
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孵卵中におけるエストロジェンの投与がニホンウズラ雄の性行動に及ぼす影響
桑山 岳人
東京農大農学集報 2002.12
Language：Japanese Publishing type：Research paper (scientific journal)
孵卵中におけるEBの投与がニホンウズラ雄の性行動、育成率、精巣の発達に大きな影響を及ぼすことを示した。
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牛における人工授精時の性腺刺激ホルモン放出ホルモン投与が受胎に及ぼす影響
門司恭典、佐藤光夫、百目鬼郁男
東京農大農学集報 2002.12
Language：Japanese Publishing type：Research paper (scientific journal)
受胎しにくい牛に対するブセレリン投与の効果を示した。
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Annual changes in serum LH and testosterone concentrations in male sika deer (Cervus nippon)
Kameyama Y、Miyamoto A、Kobayashi S、Ishijima Y
J.Reprod.Dev. 2002.12
Language：English Publishing type：Research paper (scientific journal)
シカの血漿LHおよびテストステロンの年内変動を示した。
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マイクロプレートを用いた雄シバヤギ血漿中5α-ジヒドロテストステロンの酵素免疫測定法
金子悦史、門司恭典、神戸川明、百目鬼郁男
東京農大農学集報 2002.12
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
雄シバヤギの血漿中5α-DHT濃度の測定法を確立させた。
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ニホンウズラにおける卵胞成長パターン
小川博、田中克英
東京農大農学集報 2002.09
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
ニホンウズラにおける卵胞成長パターンを明らかにした。
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Changes in tickness and weight of shell portion of egg and in weight and size of whole egg during the stay in the uterine part of oviduct (shell gland) in the guineafowl: Comparison with white leghorn hens
Ogawa H、Ueno K、Tanaka K
J.Poult.Sci. 2002.01
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウとニワトリの白色レグホーン種の卵の殻の厚さ，卵白量の違いが生ずる理由を論じた。
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Estrogen receptor binding in the oviduct magnum of guineafowl hens: Comparison with white leghorn hens
Ogawa H、Uchihashi H、Tanaka K、Takahashi T、Yasuoka T、Kawashima M
Jpn.Poult.Sci. 2000.09
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウの卵の卵白が少ないことは、卵管膨大部のエストロジェンレセプターの結合容量が少ないことに起因する可能性を示した。
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超音波画像診断によるミニチュアブタの卵巣の観察および早期妊娠診断
田中敦士、倉持浩、村上泰己、門司恭典、竹ノ内直樹、百目鬼郁男
日本養豚学会誌 2000.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
超音波画像診断によりミニチュアブタの卵巣の観察および早期妊娠診断を実施した
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ミニチュアブタの発情期における腟内電気抵抗値，腟垢像および血漿中性ステロイドホルモン濃度の変化
田中敦士、門司恭典、竹ノ内直樹、百目鬼郁男
東京農大農学集報 2000.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
腟内の生理的諸性状の観察は発情鑑定の補助手段として有効であることを示した。
-
ホロホロチョウ卵の特徴
小川博、上原万里子、内橋宏子、田中克英
日本家禽学会誌 2000.01
Language：Japanese Publishing type：Research paper (scientific journal)
ホロホロチョウ卵の形質を明らかにした。
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Parathyroid hormone receptor binding property in the shell gland of oviduct of the guineafowl during an oviposition cycle
Ogawa H、Takahashi T、Yasuoka T、Tanaka K、Kawashima M
Poultry Sci. 2000.01
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウ卵管子宮部における副甲状腺ホルモンレセプターの放卵サイクル中の結合能の推移を示した。
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Endocrinological studies on broodiness of Gifujidori chickens
桑山 岳人
東京農業大学 1999.08
Language：English Publishing type：Thesis (other)
岐阜地鶏の就巣行動と内分泌との関係について示した。（博士論文）
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ホロホロチョウ及びニワトリの血漿カルシウム、リン及びマグネシウム濃度の抱卵周期における変動
小川博、上原万里子、内橋宏子、田中克英
日本家禽学会誌 1999.05
Language：Japanese Publishing type：Research paper (scientific journal)
ホロホロチョウ及びニワトリの血漿カルシウム、リン及びマグネシウム濃度が抱卵周期中の卵殻形成に関連して変動することを示した。
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Prostaglandin F concentration in serum of hens and cooks
Takahashi T、Kawashima M、Yasuoka T、Tanaka K
Poultry Sci. 1999.01
Language：English Publishing type：Research paper (scientific journal)
雌鳥および雄鶏の血清中のプロスタグランジンFの濃度の日内変動を示した。
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Presence of melatonin receptor in the anterior lobe of pituitary of the hen
村山透、門司恭典、田中克英、高橋哲也、川島光夫
Jpn.Poult.Sci. 1998.05
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
雌鶏の下垂体前葉にメラトニンレセプターが存在することを証明した。
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ホロホロチョウとニワトリの成長初期における卵管の発達、血漿エストランジオール17β濃度の変化およびエストロジェン投与による卵管重量の増加について
小川博、田中克英
日本家禽学会誌 1998.03
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウとニワトリについて10週齢時までの体重、卵管重量、エストランジオール17β濃度の1週間毎の変化を明らかにした。また、4週齢時及び5週齢時におけるエストロジェン投与による卵管重量増加反応を比較しホロホロチョウでは若干劣ることを明らかにした。
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ウズラ精巣におけるメラトニン・レセプターの存在とその結合親和性と結合容量の昼夜による差異
村山透、門司泰典、田中克英、高橋哲也、川島光夫
日本家禽学会誌 1998.01
Language：Japanese Publishing type：Research paper (scientific journal)
ウズラの精巣にメラトニンレセプターが存在することを証明し、その結合親和性と結合容量が昼夜によって相異なることを明らかにした。
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Increase in Plasma luteinizing hormone and estradiol-17β concentrations following an Injection of luteinizing hormone-releasing hormone in incubating and brooding Gifujidori hens
Shimada K、Wada M、Tanaka K
Jpn.Poult.Sci. 1997.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
抱卵中および育雛中の岐阜地鶏にLH-RHを注射すると血漿LH濃度もエストランジオール濃度も共に増加するので、下垂体および卵巣のいずれも反応性を有することが明らかとなった。
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雌鶏の視床下部の視索前野領域および正中隆起部領域におけるメラトニン・レセプター：その存在の立証と平衡解離定数ならびに最大結合容量の変動について
村山透、門司恭典、田中克英、高橋哲也、川島光夫
日本家禽学会誌 1997.05
Language：Japanese Publishing type：Research paper (scientific journal)
雌鶏の視床下部の視索前野領域と正中隆起領域はいずれもメラトニンの標的組織とみなされ、1日のうちでメラトニンの作用する時間は産卵鶏と休産鶏とで相異なり、また両組織で相異なるものと推察した。
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Direct action of melatonin on hen ovarian granulosa cells to lower responsiveness to luteinizing hormone
Murayama T、Kawashima M、Takahashi T、Yasuoka T、Tanaka K
P.S.E.B.M. 1997.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
鶏の卵胞顆粒膜細胞にメラトニンが直接作用して黄体形成ホルモンに対する反応性を低下させることを明らかにした。
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Rapid growth phase of ovum in the guinea fowl.
Ogawa H、Tanaka T
Jpn.Poult.Sci. 1996.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウの卵胞の急速成長日数が7-11日であることを明らかにした。
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The timing of ovulation after oviposition and the time spent by the ovum in each portion of oviduct in the guinea fowl
Ogawa H、Tanaka T
Jpn.Poult.Sci. 1996.03
Language：English Publishing type：Research paper (scientific journal)
ホロホロチョウにおける排卵が放卵後15分未満に起こることを明らかにし、卵管各部における卵の滞留時間を推定した。
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Crowing characteristics of jungle fowl, Japanese native breeds and white leghorn breed of chicken
Ogawa H、Munechika I、Kono T、Ichinoe K
Jpn.Poult.Sci. 1996.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
赤色野鶏、緑襟野鶏、セイロン野鶏、日本鶏16品種および白色レグホーンの鳴声を声の高さ、長さおよび音節数についてサウンドスペクトログラフィーを用いて分析し、その特徴を示した。
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Progesterone increases pituitary VIP receptor binding in hen
S M T Gonzales、Kawashima M、Kamiyoshi M、Tanaka K、Ichinoe K
Jpn.Poult.Sci. 1994.09
Language：English Publishing type：Research paper (scientific journal)
休産鶏にプロジェステロンを注射した場合、下垂体前葉の両腺体においてVIPに対する特異的結合量が増加することを明らかにした。
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Specific binding of vasoactive intestinal peptide receptor in cephalic and caudal lobe of anterior pituitary of incubating and laying hens and roosters
S M T Gonzales、Kawashima M、Kamiyoshi M、Tanaka K、Ichinoe K
Jpn.Poult.Sci. 1994.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
VIPに対する特異的結合量が抱卵鶏においては下垂体前葉の前部腺体の方が後部腺体より多いこと。また，前部腺体における特異的結合量が抱卵鶏＞産卵鶏＞雄鶏の関係にあることを明らかにした。
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Effect of pregnant mare serum gonadotropin on incubating and brooding behavior, ovarian and oviduct weight, and plasma concentration of estradiol-17β and progesterone in broody Gifujidori hens
Namba K、Ichinoe K
Jpn.Poult.Sci. 1994.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
抱卵または育雛中の母鶏の卵巣が性腺刺激ホルモンに対して反応することを示し、またその反応性が抱卵中より育雛中の方が劣るものと推察した。
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Effect of photoperiods on testicular growth and onset of egg-laying in the guinea fowl
Ogawa H、Ichinoe K
日本家禽学会誌 1993.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
雌ホロホロチョウの初産日齢は短日条件で飼育した場合は遅れること、雄ホロホロチョウの場合30週齢における精巣重量は長日条件で飼育した場合よりはむしろ短日条件の方が大きいことを示した。
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Effect of removal of chicks from hens on concentrations of prolactin, luteinizing hormone and oestradiol in plasma of brooding Gifujidori hens
Shimada K、Saito N、Ohkubo T、Sato K、Wada M、Ichinoe K
J.Reprod.Fert. 1993.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
母鶏においてその雛の存在が下垂体からのLH分泌を抑制することを示唆した。
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Diurnal variations in plasma testosterone level in the male guinea fowl
Ogawa H、Ichinoe K
Jour.Agi.Sci. Tokyo Nogyo Daigaku 1993.01
Language：English Publishing type：Research paper (scientific journal)
雄ホロホロチョウの場合、短日・長日条件のいずれにおいても血漿テストステロン濃度は、暗期に上昇することを示した。
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雄ニホンウズラの性成熟期における血漿とクロアカ腺内Testosterone及び5α-Dihidrotestosterone濃度の推移
一戸健司
東京農大農学集報 1993.01
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
性成熟期におけるウズラクロアカ腺の急激な発達がクロアカ腺へのTestosteroneの取り込み能の上昇とTestosteroneから5-αDihidrotestosteroneへの還元反応のが急激に増大することに起因することを示唆した。
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雌ホロホロ鳥における産卵率，血中プロジェステロン、テストステロン及びエストラジオール濃度の年内変動
小川博、一戸健司
日本家禽学会誌 1991.09
Language：Japanese Publishing type：Research paper (scientific journal)
自然光周期条件で飼育されている雌ホロホロ鳥における産卵率、血漿性ステロイドホルモン濃度の年内変動について示した。
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岐阜地鶏の抱卵期における血中エストラジオール濃度に対するLH投与の影響
千葉亮、一戸健司
東京農大農学集報 1991.01
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
外因性のＬＨの投与により抱卵中の鶏の血漿エストラジオール濃度は一時的に上昇するものの、抱卵行動の継続には、影響しない事を示した。
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岐阜地鶏における雛の孵化及び除去が母鶏の就巣行動及び血中ステロイドホルモン濃度に及ぼす影響
一戸健司
東京農大農学集報 1990.01
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
雛の孵化及び除去により母鶏の抱卵・育雛期間を短縮させた場合、その短縮分だけ母鶏の次期産卵開始が早まることを示唆した。
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ホロホロ鳥における精子の形成段階および血中テストステロン濃度の成長に伴う変化
小川 博・桑山岳人・一戸健司
日本家禽学会誌 1989.09
Language：Japanese Publishing type：Research paper (scientific journal)
雄ホロホロチョウの精子の形成段階および血漿テストステロン濃度の成長に伴う変化を示した。
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性成熟期における雌鶏の血中プロゲステロン、エストラジオール及びテストステロン濃度の初産日齢との関係
伊藤博、河野友宏、一戸健司
日本家禽学会誌 1988.03
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
雌鶏の初産前後における血漿性ステロイドホルモン濃度の推移は産卵の早いグループと遅いグループとでは違うことを示した。
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未成熟雄ウズラのクロアカ腺に対するテストステロン及び5-αジヒドロテストステロンの影響
伊藤博、一戸健司
東京農大農学集報 1988.01
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
去勢した未成熟雄ウズラに5-αジヒドロテストステロンを投与した場合、テストステロンの約1/4投与量でクロアカ腺が同程度に発達することを示した。
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Pattern of nesting behavior and changes in the plasma concentrations of sex steroid hormones in Gifujidori hens during the period between hatching their incubated eggs and the onset of laying
Kono T、Itoh H、Ichinoe K
Jpn.Poult.Sci. 1987.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
育雛中の母鶏から雛を除去したところ血漿テストステロンとエストラジオール濃度が急激に上昇することを示した。
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Changes in plasma concentrations of progesterone, testosterone and estradiol during moltimg period in the Gifujidori hens, native Japanese chicken
Kono T、Itoh H、Ichinoe K
Jpn.Poult.Sci. 1986.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
秋期の自然換羽期において血漿性ステロイドホルモン濃度は、換羽の開始に伴って減少することを示した。
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Daily variations in plasma concentrations of progesterone, testosterone and estradiol in broody native Japanese breed of chicken, Gifujidori
Kono T、Ichinoe K
Jour. Agri. Sci Tokyo Nogyo Daigaku 1986.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
抱卵中の鶏の血漿性ステロイドホルモン濃度の日内変動を示した。
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Nesting behavior and changes in plasma concentrations of progesterone, testosterone and estradiol in the native Japanese breed of chicken, Gifujidori
Kono T、Itoh H、Ichinoe K
Jpn.Poult.Sci. 1985.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
抱卵開始前後における就巣行動と血漿性ステロイドホルモン濃度の変化について示した。