Papers - ISHIMI Yoshiko
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Development of a Nutrient Profiling Model for Processed Foods in Japan Reviewed
Jun Takebayashi , Hidemi Takimoto , Chika Okada , Yuko Tousen , Yoshiko Ishimi
Nutrients 16 ( 17 ) 3026 2024.09
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/nu16173026.
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Development of a Nutrient Profile Model for Dishes in Japan Version 1.0: A New Step towards Addressing Public Health Nutrition Challenges Reviewed
Yuko Tousen , Jun Takebashi , Chika Okada , Mariko Suzuki , Ai Yasudomi , Katsushi Yoshita , Yoshiko Ishimi , Hidemi Takimoto
Nutrients 16 ( 17 ) 3012 2024.09
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/nu16173012.
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Feasibility Study of the Draft Japanese Nutrient Profile Model to Support Healthy Eating Behaviors: A Cross-sectional Study Focusing on the Motivation of Behavioral Change Reviewed
Tada Yuki, Yoshizaki Takahiro, Yokoyama Yuri, Takebayashi Jun, Okada Emiko, Takimoto Hidemi, Ishimi Yoshiko
The Japanese Journal of Nutrition and Dietetics 81 ( 5 ) 246 - 259 2023.10
Language：Japanese Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective:</b> To assess the feasibility of the draft Japanese Nutrient Profile (NP) model, we developed informational materials about its utilization, and conducted Internet research to identify issues and needs according to the motivation of behavioral change.</p><p><b>Methods:</b> We developed the informational materials (4 pages, 1 A3-sided sheet) based on the NP model, as well as materials from other countries. An online cross-sectional survey was conducted among 3,000 Japanese consumers aged 18 years or older. The age, sex, and regional distribution of the participants, as well as their motivation for behavioral change, were similar to those of the National census and the National Health and Nutrition survey, respectively. The participants read the informational materials and were asked how such materials would affect their food purchasing behavior. Based on the participants' current motivation for behavioral change, they were divided into three groups: not interested (<i>n</i> = 1,187), intend to improve (<i>n</i> = 1,465), and recognition of no problem with own eating behavior (<i>n</i> = 348).</p><p><b>Results:</b> More than 90% of the respondents found the informational materials easy to understand. The number of respondents who answered that the symbols that warned against overconsumption would influence their food purchasing behavior was greater for all food groups among the group with the intention to improve, accounting for approximately 70%, in contrast to only about 40% among those who were not motivated.</p><p><b>Conclusions:</b> Our results indicated that the food labeling based on the NP model might influence consumers' healthy eating behaviors, especially among those who intend to improve their eating behaviors.</p>
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A Basic Study for the Development of a Japanese Nutrient Profile Model to Support the Practice of Healthy Eating Behavior
Tada Yuki, Yoshizaki Takahiro, Yokoyama Yuri, Takebayashi Jun, Okada Emiko, Takimoto Hidemi, Ishimi Yoshiko
Nippon Eiyo Shokuryo Gakkaishi 76 ( 1 ) 27 - 32 2023
Language：Japanese Publisher：Japan Society of Nutrition and Food Science
<p>A nutrient profile model (NP model) ranks foods according to their nutritional composition, allowing individuals to make well-informed dietary choices. In other countries, the application of NP models is reportedly associated with healthier food choices and health indicators. We examined a NP model applicable to the Japanese population for processed foods and preparing dishes. Considering the nutrition status of the Japanese population, we proposed that the model should target those aged 18 years or older. A category-specific model was adopted with setting thresholds to avoid overconsumption of total fat, saturated fat, sodium or salt equivalent, and energy for processed foods and prepared foods. We set the nutrient criteria for the proposed model and determined thresholds for each food category. In order to set the salt threshold for each dish, we conducted secondary analyses of the 2014‐2018 National Health and Nutrition Survey. The food groups according to dish type were compared between “high salt” consumers and “adequate” consumers. Furthermore, we conducted an online cross-sectional feasibility survey among 3,000 consumers. Here we describe the development procedure and feasibility of the proposed Japanese NP model to support the practice of healthy eating behavior.</p>
DOI： 10.4327/jsnfs.76.27
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(S)-Equal is more effective than (R)-equal om inhibiting osteoclast formation and enhancing osteoclast apoptosis, and reduces estrogen deficiency-induced bone loss in mice Reviewed
Tanaka S, Fujii S, Inoue H, Takahashi N, Ishimi Y, Uehara M
J. Nutr. 152 ( 8 ) 1831 - 1842 2022.06
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1093/jn/nxac130
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Tada Yuki, Yoshizaki Takahiro, Yokoyama Yuri, Takebayashi Jun, Okada Emiko, Takimoto Hidemi, Ishimi Yoshiko
The Japanese Journal of Nutrition and Dietetics 80 ( 2 ) 126 - 138 2022.04
Language：Japanese Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective:</b> To increase awareness and dissemination of a nutrient profile model (NP model) in Japan, we analyzed data from consumers and identified issues they had.</p><p><b>Methods:</b> In February 2021, we conducted focus group interviews lasting roughly 2 hours with six groups of individuals according to age and sex. The age range was 18–74 years, and 36 individuals participated. Participants were individuals who purchased processed foods 2–3 times per week or more. Participants with specialized nutritional training or little desire to change their eating habits were excluded. Coding and categorization of data from the verbatim transcript and observational records were performed via content analysis.</p><p><b>Results:</b> Participants categorized the nutrition facts labels into "impractical to convert to individual serving amounts" and "I don't know what percentage or standard to use for daily intake." Participants favored NP model displays that clearly noted which nutrients were above the daily intake requirement, especially those that were color-coded and provided supplemental explanations. Many stated that while this did not influence their choice of their favorite foods, it did make them reconsider foods that were not favorites.</p><p><b>Conclusions:</b> For the NP model to support the practice of healthy eating habits among consumers, it is essential to offer immediate and clear notifications that are easy to understand. Consumer feedback indicated that the NP model notifications did not influence their choice of favorite foods. Therefore informational material to raise awareness of using the NP model should include dietary lifestyles.</p>
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Basic Research on a Nutrient Profile Model for Japan: Draft Development and Validation Reviewed
Ishimi Yoshiko, Takebayashi Jun, Yokoyama Yuri, Yoshizaki Takahiro, Tada Yuki, Okada Emiko, Takimoto Hidemi
The Japanese Journal of Nutrition and Dietetics 80 ( 2 ) 79 - 95 2022.04
Language：Japanese Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective:</b> The selection of appropriate food groups is essential to promote a healthy diet. A nutrient profile model ranks foods according to their nutritional composition, allowing an individual to make well-informed dietary choices. Nutrient profile models have already been developed in other countries but not in Japan. Therefore, this study aimed to draft a nutritional profile model applicable to the Japanese population.</p><p><b>Methods:</b> A draft of a Japanese nutrient profile model for processed food was developed and validated using the World Health Organization (WHO) 2010 technical meeting report, WHO guiding principles and framework manual for front-of-pack labeling for promoting healthy diet in 2019, and models used in other countries. Data from the Japanese National Health and Nutrition Survey (NHNS), Dietary Reference Intakes for Japanese (2020), Standard Tables of Food Composition in Japan 2015 (7<sup>th</sup> revised edition), and Nikkei-POS database were used.</p><p><b>Results:</b> 1. Considering the nutrition status of the Japanese population, the target population age was set to 18 years or older, and the specific nutrients were total fat, saturated fat, sodium (salt equivalent), and energy. 2. A category-specific (threshold setting) model was selected, and the target foods included processed and prepared foods (ready-to-eat meals). Processed foods were further classified into 15 categories based on the Japanese NHNS. 3. The criteria for the Japanese nutrient profile model were determined and thresholds of the items were set to each food category.</p><p><b>Conclusions:</b> The draft of the Japanese nutrient profile model was developed according to the Japanese public nutrition status.</p>
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Information Analysis on Health Food Ingredients That are Predicted to Cause Damage to the Liver Reviewed
Kondo Takashi, Ishimi Yoshiko, Tousen Yuko
The Japanese Journal of Nutrition and Dietetics 79 ( 5 ) 311 - 319 2021.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective:</b> "The collection of health hazard information from foods containing ingredients that require special attention" was established in an amendment of the Food Sanitation Act. The worsening of liver function indices is the most common serious health hazard caused by health foods that have been reported. From these backgrounds, safety research for health foods focusing on the hepatic effects is urgently needed. This study was conducted to search for health food ingredients that are predicted to cause health damage to the liver.</p><p><b>Methods:</b> Databases on health food materials, including "Handbook for materials of functional food" (book), "Information system on safety and effectiveness for health foods" (web; information from 2004 to July 2019), and "all of health foods and supplement's ingredients 2017" (book) were searched to extract information on the materials and ingredients of health foods that affected liver function indices and hepatic drug metabolism.</p><p><b>Results:</b> In total, 1,313 items of information on health food materials were obtained, of which 211 contained information about effects on liver function. The components contained in these 211 materials including tannin (26 cases), flavonoids (20 cases), saponins (11 cases), and so on, were superordinated. Of these 211 materials, 57 contained polyphenols.</p><p><b>Conclusions:</b> The effect of health food materials containing polyphenols on the liver was suggested. In the future, it would be necessary to study these effects in cell and animal experiments in order to estimate the cause-and-effect relationship between health food ingredients and their hepatic effects.</p>
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Nutrient Profiles of Dishes Consumed by the Adequate and High-Salt Groups in the 2014–2018 National Health and Nutrition Survey, Japan Reviewed
Takimoto H, Okada E, Takebayashi J, Tada Y, Yoshizaki T, Yokoyama Y, Ishimi Y
Nutrients 13 ( 8 ) 2591 2021.07
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3390/nu13082591
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Yokoyama Yuri, Yoshizaki Takahiro, Tada Yuki, Okada Emiko, Takebayashi Jun, Takimoto Hidemi, Ishimi Yoshiko
The Japanese Journal of Nutrition and Dietetics 79 ( 3 ) 50 - 61 2021.06
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective:</b> Nutrient profile (NP) models, which classify or rank foods according to their nutritional composition, are commonly used as a nutrition policy in countries outside of Japan to evaluate the nutritional quality of foods. This study investigated the characteristics of NP models in other countries to determine the challenges that should be considered when developing a Japanese NP model.</p><p><b>Methods:</b> Using the available data on existing NP models, shared in the "Discussion paper on general guidelines to establish nutrient profiles for food labelling" from the agenda of the 41st session of the Codex Committee on Nutrition and Foods for Special Dietary Uses, target NP models (<i>n</i> = 97) were identified.</p><p><b>Results:</b> From the 97 models, 22 matched the inclusion criteria. These models were from Latin America (<i>n</i> = 1), North America (<i>n</i> = 5), Europe (<i>n</i> = 5), the Middle East (<i>n</i> = 1), Oceania (<i>n</i> = 2), Asia (<i>n</i> = 6), and international (regional offices of the WHO) (<i>n</i> = 2) sources. The models were developed for Front-of-Pack Labelling (<i>n</i> = 11), and regulation of health and nutrition claims (<i>n</i> = 5) were targeted to a general population, whereas the models developed to restrict marketing (<i>n</i> = 6) were targeted to a child population. Out of the 22 models, 16 used thresholds, five used scoring, and one used both. Most NP models were developed under the consideration that energy and some nutrients, such as fat, saturated fatty acids, trans fatty acids, sugars, and sodium should be limited.</p><p><b>Conclusion:</b> Developing the Japanese NP model will face challenges when determining targeted nutrients, food categories, and type of model.</p>
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Ensuring the Reliability of Food Nutrition Labeling in Japan: Regulation and Laboratory Analysis
Takebayashi Jun, Suzuki Ippei, Chiba Tsuyoshi, Umegaki Keizo, Ishimi Yoshiko
The Japanese Journal of Nutrition and Dietetics 78 ( Supplement ) S91 - S100 2020.12
Language：English Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective:</b> To review the regulatory system for nutrition labeling, especially for nutrient declaration, in Japan, and to highlight the contributions made by the National Institute of Health and Nutrition (NIHN) with regard to the reliability of nutrition labeling of food in recent years.</p><p><b>Methods:</b> We investigated the laws and official documents related to nutrition labeling of food in Japan, as well as relevant academic papers published by the NIHN from 1996 to 2020.</p><p><b>Results:</b> In Japan, under the Food Labeling Act, nutrient declaration of the five nutritional components, namely energy, protein, fat, carbohydrates, and salt equivalent, has been mandatory for all prepackaged processed foods since 2015. Declared nutritional values should be consistent with the values obtained by laboratory analysis in principle, but "the value obtained by reasonable estimate" is permitted under certain conditions. Laboratory analysis is indispensable for verifying the accuracy of label values of foods with nutrient content or health claims. The NIHN has contributed to the regulatory system of nutrition labeling from the following three standpoints: 1) legal inspection body for the Foods for Special Dietary Uses, including the Foods for Special Health Uses, (approval testing) and other prepackaged foods bearing nutrient declaration (compliance testing); 2) proficiency testing provision for organizations performing food nutrition analysis; and 3) research institute to develop and improve analytical methods for nutritional and functional components in foods.</p><p><b>Conclusions:</b> The NIHN has played pivotal roles in ensuring the reliability of nutrition labeling for more than half a century and will continue to do so in the future.</p>
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Tousen Yuko, Kondo Takashi, Chiba Tsuyoshi, Ishimi Yoshiko
The Japanese Journal of Nutrition and Dietetics 78 ( Supplement ) S80 - S90 2020.12
Language：English Publisher：The Japanese Society of Nutrition and Dietetics
<p><b>Objective</b>: This article aimed to review the Japanese regulation of the food labelling systems for health and nutrition, and associated role of the National Institute of Health and Nutrition (NIHN).</p><p><b>Methods</b>: We investigated the development of standards and challenges associated with the Japanese regulation of food labelling system for health and nutrition. We also examined the contribution of the National Institute of Health and Nutrition to the development of the systems.</p><p><b>Results</b>: In 1991, the Ministry of Health and Welfare established the concept of Foods for Specified Health Uses (FOSHU), under the Nutrition Improvement Act. In 2001, the labelling system for vitamins and minerals was established under the Foods with Nutrient Function Claims regulations, and the Foods with Health Claims (FHC) system was set up with FOSHU. In 2015, the Foods with Function Claims classification was established under the Food Labelling Act by the Consumer Affairs Agency. Despite the regulated food labelling system in Japan, some "health foods" may have inappropriate use and labelling. The NIHN functions to (1) measure the amount of nutrients and ingredients in foods, ensuring accurate information on the labels for approval by the foods labelling system; (2) assesses safety and efficacy of health foods including FHC providing scientific evidences on their nutritional and physiological effects; and (3) provide reliable online information regarding health foods, the FHC and their labelling.</p><p><b>Conclusions</b>: The NIHN has an important role within the regulation systems of health foods including FHC system in Japan.</p>
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The combination of soy isoflavones and resveratrol preserve bone mineral density in hindlimb-unloaded mice. Reviewed
Y. Tousen, R. Ichimaru, T. Kondo, M. Inada, C. Miyaura, Y. Ishimi
Nutrients 12 ( 2043 ) 1 - 13 2020.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Assessment of safety and efficacy of pine bark extract in normal and ovariectomized mice. Reviewed
Kondo T, Ishimi Y, Takebayashi J, Tousen Y.
J Food Sci 85 1956 - 1962 2020.06
Language：English Publishing type：Research paper (scientific journal)
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Proficiency Testing Schemes for Food Nutrition Analysis in Japan (2017–2018) Reviewed
Takebayashi Jun, Takasaka Noriko, Suzuki Ippei, Nakasaka Toshiaki, Hirabayashi Naoyuki, Ishimi Yoshiko, Umegaki Keizo, Chiba Tsuyoshi, Watanabe Takaho
Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 61 ( 2 ) 63 - 71 2020.05
Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Food Hygiene and Safety
<p>This paper deals with proficiency testing schemes for food nutrition analysis in Japan. In schemes in 2017 and 2018, 65 and 73 organizations participated, respectively, and more than 70% of the participants were public organizations responsible for a nutrition-labeling compliance test. The food matrices were pork and chicken sausages, and analytes were protein, fat, ash, moisture, carbohydrate, energy, sodium, salt equivalent, calcium (2018 only), and iron (2018 only). The organizations reporting inadequate laboratory values in one or more nutrients for mandatory declaration (energy, protein, fat, carbohydrate, or salt equivalent) were 11 and 15% of all organizations and 9 and 13% of public organizations in the 2017 and 2018 schemes, respectively. The approximate relative standard deviations for proficiency assessment (RSDr) were as follows: protein, 2%; fat, 3%; ash, 2%; moisture, 0.5%; carbohydrate, 9%; energy, 1%; sodium (salt equivalent), 4%; calcium, 7%; and iron, 7%. Notably, the large RSDr value for carbohydrate may cause inconsistency among laboratories in compliance tests for foods containing several grams or less of carbohydrate per 100 grams.</p>
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1．日本人の食事摂取基準（2020 年版）と健康づくり(市民公開シンポジウム『飽食時代の隠れ栄養失調：健康寿命に影響するビタミン・ミネラル不足』）
石見 佳子
ビタミン 94 ( 4 ) 291 - 295 2020.04
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Activation of peroxisome proliferator-activated receptor gamma/small heterodimer partner pathway prevents high fat diet-induced obesity and hepatic steatosis in Sprague-Dawley rats fed soybean meal. Reviewed
Y Matsumoto, Y Ishimi, T Suzuki, K Kobayashi, J Inoue, Y Yamamoto
J Nutr Biochem 75 1 - 7 2020.01
Language：English Publishing type：Research paper (scientific journal)
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PRISMA声明チェックリスト：機能性表示食品のための拡張版」における追加項目の開発 Reviewed
上岡洋晴、山本（前田）万里、津谷喜一郎、折笠秀樹、大室弘美、島田美樹子、北湯口純、吉﨑貴大、和田安代、石見佳子
薬理と治療 47 ( 12 ) 1963 - 1973 2019.12
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)
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Quality assessment of health foods containing licorice in Japanese market.
Ishimi Y, Takebayashi J, Tousen Y, Yamauchi J, Fuchino Y, Kawano T, Inui T, Yoshimatsu Y, Kawahara N.
Toxcol Rep 6 904 - 913 2019.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
日本の市場で販売されている植物由来成分を含む健康食品について、品質評価の方法を構築することを目的とし、「カンゾウ」を含む健康食品に含まれる、薬効成分、機能性成分を定量するとともに、植物の遺伝子鑑別を行った。また、in vitroで抗酸化活性、エストロゲン活性を評価するとともに、ラットを用いてカンゾウ摂取が肝臓のCYP活性、骨・脂質代謝に及ぼす影響を評価した。
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Anti-Osteoporotic Effect of Soy Isoflavones Intake on Low Bone Mineral Density Caused by Voluntary Exercise and Food Restriction in Mature Female Rats.
Yanaka K, Higuchi M, Ishimi Y.
J Nutr Sci Vitaminol (Tokyo). 65(4):335-342, 2019 65 ( 4 ) 335 - 342 2019.08
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3177/jnsv.65.335
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エストロゲン活性を示す健康食品の検出 Reviewed
山内淳、小暮更紗、坂口俊英、米澤加代、谷岡由梨、古庄律、竹林純、東泉裕子、石見佳子
日本栄養・食糧学会誌 72 ( 4 ) 159 - 163 2019.08
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
培養細胞を用いたルシフェラーゼレポーターアッセイ系が、健康食品のエストロゲン活性を検出する有効な手法の一つであることを示した。
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Comparison of nutrient reference values for food labeling in Japan with CODEX recommendations, based on DRIs and nutrient intake in Japan. Reviewed
Tsuboyama-Kasaoka N, Takimoto H, Ishimi Y.
J Nutr Sci Vitaminol 65 102 - 105 2019.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Tsuboyama-Kasaoka N, Takimoto H, Ishimi Y. 、日本人の実態に基づいた検討を行うため、コーデックス栄養・特殊用途食品部会において設定された栄養参照量（NRVs）を基準として、国民健康・栄養調査を利用し、NRVs以上者および未満者の割合、それぞれの集団特性を比較した。共同研究につき担当部分抽出不可能。
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Resistant Starch Attenuates Bone Loss in Ovariectomised Mice by Regulating the Intestinal Microbiota and Bone-Marrow Inflammation. Reviewed
Tousen Y, Matsumoto Y,Nagata Y, Kobayashi Y, Inoue M, Ishimi Y.
Nutrients 11 ( 2 ) E297 2019.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
食物繊維に属するレジスタントスターチが、骨髄における炎症を抑制することで、エストロゲン欠乏マウスの骨量減少を抑制することを明らかにした。
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β-Carotene prevents bone loss in hind limb unloading mice Reviewed
Matsumoto Y, Tousen Y, Ishimi Y.
J Clin Biochem Nutr. 63 42 - 49 2018.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
βカロテンが、非荷重モデルマウスの骨量減少を抑制することを明らかにした。
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Effect of daidzein and equol on DNA replication in MCF-7 cells. Reviewed
Tsuji M, Tanaka T, Nagashima R, Sagisaka Y, Tousen Y, Nishide Y, Ishimi Y, Ishimi Y.
The Journal of Biochemistry 163 ( 5 ) 371 - 380 2018.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Tsuji M, Tanaka T, Nagashima R, Sagisaka Y, Tousen Y, Nishide Y, Ishimi Y, Ishimi Y.乳がん細胞株の増殖に対するエクオールの影響を評価した。共同研究につき担当部分抽出不可能。
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The effects of green kiwifruit combined with isoflavones on equol production, bone turnover and gut microflora in healthy postmenopausal women. Reviewed
Kruger MC, Middlemiss C, Katsumata S, Tousen Y, Ishimi Y.
Asia Pac J Clin Nutr. 27 ( 2 ) 347 - 358 2018.02
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
イソフラボンとキウイフルーツの併用摂取が、閉経後女性の血中骨代謝マーカーを改善することを明らかにした。
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エゾウコギ摂取が閉経後早期モデルマウスの肝臓薬物代謝酵素および骨密度に及ぼす影響 Reviewed
東泉裕子、松本雄宇、西出依子、山内淳、竹林純、渕野裕之、河野徳昭、吉松嘉代、川原信夫、石見佳子
栄養学雑誌 75 ( 6 ) 151 - 163 2017.12
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
エゾウコギ摂取の安全性及び骨代謝に対する有用性を骨粗鬆症モデルマウスを用いて評価した。
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小型の測定容器を用いた特別用途食品えん下困難者用食品の物性測定方法の開発 Reviewed
竹林純、山内淳、東泉裕子、石見佳子
栄養学雑誌 75 ( 3 ) 104 - 112 2017.06
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
えん下困難者用食品の分析方法を開発し、公定法を提案した。
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栄養表示のための栄養参照量の国際比較 Reviewed
石見佳子、笠岡（坪山）宜代
栄養学雑誌 75 ( 1 ) 39 - 46 2017.02
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
栄養素等表示基準値の改定のため、国際的な比較を行った。
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栄養成分表示値の信頼性確保‐主要栄養成分に関する分析技能試験の試み‐ Reviewed
竹林 純, 松本輝樹, 石見佳子
栄養学雑誌 75 ( 1 ) 3 - 18 2017.02
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
栄養成分表示の義務化に向け、登録試験機関間の精度管理に関する室間試験を実施し、良好な結果を得た。
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Combined effects of soy isoflavones and docosahexaenoic acid on osteoclast formation. Reviewed
Katsumata S, Plimmer G G, Tadaishi M, Tousen Y, Ishimi Y.
J Food Nutr Res 4 ( 7 ) 429 - 435 2016.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
破骨細胞形成に対するイソフラボンとDHAの併用効果を評価し、形成を抑制することを明らかにした。
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Kanamycin inhibits daidzein metabolism and abilities of the metabolites to prevent bone loss in ovariectomized mice. Reviewed
Katsumata S, Fujioka M, Fujii S, Takeda K, Ishimi Y, Uehara M.
BioMed Central Research Notes 9 334 2016.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Katsumata S, Fujioka M, Fujii S, Takeda K, Ishimi Y, Uehara M.カナマイシン経口投与が、ダイゼインからエクオールへの代謝を抑制することを動物モデルで明らかにした。共同研究につき担当部分抽出不可能。
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The combined effects of soya isoflavones and resistant starch on equol production and trabecular bone loss in ovariectomised mice. Reviewed
Tousen Y, Matsumoto Y, Matsumoto C, Nishide Y, Nagahata Y, Kobayashi I, Ishimi Y.
Br J Nutr. 116 ( 2 ) 247 - 257 2016.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
イソフラボンとレジスタントスターチの併用が、骨粗鬆症モデルマウスの骨量減少を抑制することを明らかにした。
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A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice. Reviewed
Fujii S, Takahashi N, Inoue H, Katsumata SI, Kikkawa Y, Machida M, Ishimi Y, Uehara M.
Biosci Biotechnol Biochem. 80 ( 8 ) 1632 - 1635 2016.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Fujii S, Takahashi N, Inoue H, Katsumata SI, Kikkawa Y, Machida M, Ishimi Y, Uehara M. イソフラボンとオリゴ糖の併用が、骨粗鬆症モデルマウスの骨量減少を抑制することを明らかにした。共同研究につき担当部分抽出不可能。
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Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro. Reviewed
Yuan SY, Sheng T, Liu LQ, Zhang YL, Liu XM, Ma T, Zheng H, Yan Y, Ishimi Y, Wang X
Chin J Nat Med. 14 ( 4 ) 265 - 269 2016.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Yuan SY, Sheng T, Liu LQ, Zhang YL, Liu XM, Ma T, Zheng H, Yan Y, Ishimi Y, Wang XX.葛のイソフラボンが骨粗鬆症モデルマウスの骨量減少を抑制することを明らかにした。共同研究につき担当部分抽出不可能。
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ICP-AESによる栄養表示のためのモリブデン定量法の単一試験室による妥当性確認 Reviewed
松本輝樹、市田尚子、竹林純、加藤美智子、石見佳子
日本食品化学学会誌 23 ( 1 ) 49 - 54 2016.04
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
栄養表示のためのモリブデンの分析方法を開発して妥当性確認を行い、公定法を提案した。
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Combined effects of soy isoflavones and milk basic protein on bone mineral density in hind-limb unloaded mice. Reviewed
Matsumoto Y, Tousen Y , Nishide Y , Tadaishi M, Kato K , Ishimi Y.
J Clin Biochem Nutr. 58 ( 2 ) 141 - 145 2016.03
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
イソフラボンと乳塩基性タンパク質の併用摂取が、非荷重モデルマウスの骨量減少を抑制することを明らかにした。
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閉経後骨粗鬆症モデルマウスの骨密度低下および脂肪蓄積に対するレジスタントスターチの抑制作用 Reviewed
松本雄宇、東泉裕子、小野莉奈、倉沢新一、長畑雄也、小林功、石見佳子
日本食物繊維学会誌, ルミナコイド研究 20 ( 1 ) 13 - 20 2016.02
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
レジスタントスターチの摂取が、閉経後骨粗鬆症モデルモデルマウスの骨代謝及び脂質代謝を改善することを明らかにした。
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Effect of kiwifruit on bone resorption in ovariectomized mice. Reviewed
Katsumata S, Wolber FM, Tadaishi M, Tousen Y, Ishimi Y, Kruger MC.
J Nutr Sci Vitaminol 61 ( 4 ) 332 - 337 2015.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Katsumata S, Wolber FM, Tadaishi M, Tousen Y, Ishimi Y, Kruger MC.共同研究につき担当部分抽出不可能。
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Equol, a metabolite of daidzein, is more efficient than daidzein for bone formation in growing female rats. Reviewed
Tousen Y, Ishiwata H, Ishimi Y, Ikegami S.
Phytotherapy Research 29 ( 9 ) 1349 - 1354 2015.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Tousen Y, Ishiwata H, Ishimi Y, Ikegami S.エクオールが成長期のラットの骨形成を促進することを明らかにした。共同研究につき担当部分抽出不可能。
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栄養成分表示値の信頼性確保―栄養成分に係る試験機関の技能試験方法の構築に関する予備的検討― Reviewed
竹林純、松本輝樹、石見佳子
栄養学雑誌 73 ( 1 ) 1 - 8 2015.02
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
登録検査機関間の栄養表示に係る栄養成分の分析精度管理の方法を構築し、精度管理の実施に向けた方策を提案した。
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Assessment of safety and efficacy of perinatal or peripubertal exposure to daidzein on bone development in rats. Reviewed
Tousen Y, Ihsiwata H, Takeda K, Ishimi Y.
Toxicology Reports 2 429 - 436 2015.02
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
周産期及び成長期ラットにおけるダイゼイン摂取の安全性と骨形成に対する作用を評価した。
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Associations between the Serum 25(OH)D Concentration and Lipid Profiles in Japanese Men. Reviewed
Sun X, Cao ZB, Tanisawa K, Ito T, Oshima S, Ishimi Y, Tabata I, Higuchi M.
J Atheroscler Thromb. 22 ( 4 ) 355 - 362 2015.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Sun X, Cao ZB, Tanisawa K, Ito T, Oshima S, Ishimi Y, Tabata I, Higuchi M.日本人男性を対象に、血中ビタミンD濃度と脂質代謝に関連があることを明らかにした。共同研究につき担当部分抽出不可能。
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Combined Effects of Soy Isoflavones and β-Carotene on Osteoblast Differentiation. Reviewed
Nishide Y , Tousen Y , Tadaishi M, Inada M, Miyaura C , Kruger MC, Ishimi Y.
Int J Environ Res Public Health. 12 ( 11 ) 13750 - 13761 2015.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
イソフラボンとβカロテンの併用が、骨芽細胞の分化を促進することを明らかにした。
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レスベラトロールが閉経後早期モデルマウスの肝臓薬物代謝酵素遺伝子発現に及ぼす影響. Reviewed
東泉裕子、市田尚子、西出依子、石見佳子
栄養学雑誌 72 ( 4 ) 193 - 199 2014.08
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
レスベラトロールの摂取が骨粗鬆症モデルマウスの肝臓薬物代謝酵素活性に影響を及ぼすことを明らかにした。
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Effects of daidzein and kiwifruit on bone mineral density and equol production in ovariectomised rats. Reviewed
Tousen Y, Wolber FM, Chua WH, Tadaishi M, Ishimi Y, Kruger MC.
Int J Food Sci Nutr. 65 ( 3 ) 360 - 367 2014.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Tousen Y, Wolber FM, Chua WH, Tadaishi M, Ishimi Y, Kruger MC.ダイゼインとキウイフルールの併用摂取が骨粗鬆症モデルラットの骨量減少を抑制することを明らかにした。共同研究につき担当部分抽出不可能。
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Determination of molybdenum content for nutrition labelling by ICP-MS: single laboratory validation. Reviewed
Matsumoto T, Takebayashi J, Ichida N, Kato M, Ishimi Y.
Jpn J Food Chem Safety 21 ( 1 ) 72 - 76 2014.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
栄養表示のためのモリブデンの分析方法を開発し、妥当性確認を行った。
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Low-dose of vitamin K (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. Reviewed
Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita K, Ishimi Y.
J Bone Miner Metab. 32 ( 2 ) 142 - 150 2014.03
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
低用量のビタミンKの摂取が、閉経後女性の骨代謝マーカーを改善することを明らかにした。
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Cooperative effects of soy isoflavones and carotenoids on osteoclast formation. Reviewed
Tadaishi M, Nishide Y, Tousen Y, Kruger MC, Ishimi Y.
J Clin Biochem Nutr. 54 109 - 115 2014.03
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
イソフラボンとカロテノイドの併用が、破骨細胞形成を抑制することを明らかにした。
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Hesperidin prevents androgen deficiency-induced bone loss in male mice. Reviewed
Chiba H, Kim H, Matsumoto A, Akiyama S, Ishimi Y, Suzuki K, Uehara M.
Phytother Res, 28 ( 2 ) 289 - 295 2014.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Chiba H, Kim H, Matsumoto A, Akiyama S, Ishimi Y, Suzuki K, Uehara M.ヘスペリジンがアンドロゲン欠乏による骨量減少を抑制することを明らかにした。共同研究につき担当部分抽出不可能。
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Association between serum 25-hydroxyvitamin D and inflammatory cytokines in healthy adults. Reviewed
Sun X, Cao ZB, Zhang Y, Ishimi Y, Tabata I, Higuchi M.
Nutrients 6 221 - 230 2014.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Sun X, Cao ZB, Zhang Y, Ishimi Y, Tabata I, Higuchi M.健常な日本人を対象に、血中のビタミンD濃度と炎症性サイトカインの関連を評価した。共同研究につき担当部分抽出不可能。
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Distribution of 24-hour urinary equol excretion as an indicator of the physiological range in healthy Japanese equol excretors. Reviewed
Ueno T, Abiru Y, Uchiyama S, Ishimi Y.
J Funct Food 7 129 - 135 2014.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
全国の日本人を対象に、エクオール産生能を評価した。
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Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: A pilot study. Reviewed
Tousen Y, Uehara M, Abe F, Kimira Y, Ishimi Y.
Nutr J 12(1):127 12 ( 1 ) 127 2013.09
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
短期間のオリゴ糖摂取が閉経後日本人女性のエクオール産生に対する影響を評価した。
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Role of nuclear localization of PSMB1 on transcriptional activation. Reviewed
Yamauchi J, Sekiguchi M, Shirai T, Yamada M, Ishimi Y.
Biosci. Biotech. Biochem. 77(8):1785-7 77 ( 8 ) 1785 - 1787 2013.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Yamauchi J, Sekiguchi M, Shirai T, Yamada M, Ishimi Y.転写因子PSMB1の活性化に関する検討をin vitroで行った。共同研究につき担当部分抽出不可能。
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Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice. Reviewed
Nishide Y, Tadaishi M, Tousen Y, Inada M, Miyaura C, Ishimi Y.
J Clin Biochem Nutr. 53(1):41-8, 2013 53 ( 1 ) 41 - 48 2013.07
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
骨粗鬆症モデルマウスの骨量減少に対するエクオールの有用性は、骨髄の炎症抑制作用を介していることを明らかにした。
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Hydrophilic antioxidant capacities of vegetables and fruits commonly consumed in Japan and estimated average daily intake of hydrophilic antioxidants from these foods. Reviewed
Takebayashi J, Oki T, Watanabe J, Yamasaki K, Chen J, Sato-Furukawa M, T. Utsugi M, Taku K, Goto K, Matsumoto T, Ishimi Y.
J Food Compo Analys 29:25-31 29 25 - 31 2013.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Takebayashi J, Oki T, Watanabe J, Yamasaki K, Chen J, Sato-Furukawa M, T. Utsugi M, Taku K, Goto K, Matsumoto T, Ishimi Y.日本人が摂取している野菜と果物の抗酸化能をORAC法により測定し、日本人の抗酸化物質の摂取量を推定した。共同研究につき担当部分抽出不可能。
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Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. Reviewed
Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y.
J Bone Miner Metab. 31(1):16-25 31 ( 1 ) 16 - 25 2013.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
健康食品成分メチルスルホニルメタンの安全性と膝関節の炎症に対する影響について関節炎モデルマウスうぃ用いて評価した。
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Bi-phasic effect of equol on adipocyte differentiation of MC3T3-L1 cells. Reviewed
Nishide Y, Tousen Y, Inada M, Miyaura C, Ishimi Y.
Biosci. Biotech. Biochem. 77(1): 201-204 77 ( 1 ) 201 - 204 2013.01
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
骨芽細胞におけるエクオールの作用の二相性について報告した。