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Okubo Michiko Associate Professor |
From School 【 display / non-display 】
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Kitasato University Faculty of Veterinary Medicine and Animal Sciences Graduated
- 2010.03
Country：Japan
From Graduate School 【 display / non-display 】
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Azabu University Graduate School, Division of Veterinary Medicine Doctor Course Completed
- 2014.03
Country：Japan
Employment Record in Research 【 display / non-display 】
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Tokyo University of Agriculture Faculty of Bio-Industry Department of Northern Biosphere Agriculture Associate Professor
2023.04
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Tokyo University of Agriculture Faculty of Bio-Industry Department of Bio-production Assistant Professor
2015.04 - 2018.03
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Tokyo University of Agriculture Faculty of Bio-Industry Department of Northern Biosphere Agriculture Assistant Professor
2018.04 - 2023.03
Papers 【 display / non-display 】
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Assessment of anti-Müllerian hormone levels as a reproductive indicator in Japanese Black cattle
KOYAMA Takeshi, SUZUKI Hiromi, SHIMIZU Miki, MIZUNO Riuru, ISHIGAMI Ayaha, KAMIDATE Nobuyuki, OTANI Yoshihisa, OKUBO Michiko, SOUMA Kousaku, HIRAYAMA Hiroki
Journal of Reproduction and Development 70 ( 6 ) 389 - 395 2024
Language：English Publisher：The Society for Reproduction and Development
<p> The size of the ovarian reserve, an indicator of the number of primordial follicles, varies widely among individuals, and declines with age. However, the association between the ovarian reserve and fertility remains unclear. Therefore, in the present study, we analyzed the relationship between plasma concentrations of anti-Müllerian hormone (AMH), a marker of ovarian reserve, and reproductive outcomes in Japanese Black cattle. AMH level quartiles were positively associated with pregnancy following artificial insemination (AI), and the median number of days to pregnancy in Q4 (13 days, 95% confidence interval [CI] = 7–18 days) was significantly shorter than that in Q1 (21 days, 95% CI = 15–46 days). The odds ratio for the predicted pregnancy rate by logistic regression analysis in Q4 (4.06, 95% CI = 1.54–10.67) was also significantly higher than that in Q1. Plasma AMH concentrations were significantly higher in summer (June–August) than in winter (December–February). Furthermore, a strong correlation (r = 0.856, P < 0.001) was observed between plasma AMH concentrations at 2 and 14 months of age. Calves with plasma AMH concentrations of > 700 pg/ml at 2 months old showed a transient increase and maximum AMH concentration within 5 months of birth. Overall, the results of this study indicate that the plasma AMH concentration serves as a predictive marker for the probability of conception following AI in Japanese Black cattle. The current findings contribute to the reliable assessment of AMH production and the early prediction of reproductive performance in sexually mature heifers.</p>
DOI： 10.1262/jrd.2024-047
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Carcass traits and fat quality of breeding emu (Dromaius novaehollandiae) in Northern Japan Reviewed
Y. Koshiishi, M. Murata-Okubo, H. Nakajyo, R. Machida, T. Yamamoto, T Myoda, Y. Kameyama, H. Hirayama, K. Souma, M. Yokohama, K. Wada.
Poultry Science 101 ( 10 ) 102050 2022.10
Language：English Publishing type：Research paper (scientific journal)
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Seroprevalences Against Paracoccidioides cetii: A Causative Agent for Paracoccidiomycosis Ceti (PCM-C) and Coccidioides posadasii; for Coccidioidomycosis (CCM) in Dall's Porpoise (Phocoenoides dalli) and Harbor Porpoise (Phocoena phocoena) Stranded at Hokkaido, Japan Reviewed International coauthorship
H. Kanegae, A. Sano, M. Okubo-Murata, A. Watanabe, R. Tashiro, T. Eto, K. Ueda, Md A. Hossain, E. Nakagawa Itano.
Mycopathologia 187 ( 4 ) 385 - 391 2022.06
Language：English Publishing type：Research paper (scientific journal)
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Discrimination between two chromatic colors in sika deer Reviewed
M. Okubo, M. Sato, W. Tamamura, S. Tsutsumi, S. Morie, K. Souma.
Applied Animal Behaviour Science 247 105536 2022.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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INABA Ryo, KAWAHARA-MIKI Ryouka, SHINOZAWA Akihisa, YASUHARA Taichi, FUJII Takashi, KOYAMA Keisuke, MURATA-OKUBO Michiko, SOUMA Kousaku, HIRAYAMA Hiroki
Journal of Reproduction and Development 68 ( 1 ) 30 - 37 2022.02
Language：English Publishing type：Research paper (scientific journal) Publisher：The Society for Reproduction and Development
<p> Although hormonal induction of parturition in cattle results in the successful delivery of healthy calves, the risk of retained fetal membrane is significantly increased. In a previous study, a combination of the long-acting glucocorticoid, triamcinolone acetonide, with a high dose of betamethasone partially normalized the placentomal gene expression during parturition; however, the incidence of retained fetal membrane remained high. This study further explored placentomal dysfunction and aimed to elucidate the mechanism of retained fetal membrane in parturition-induced cows. In this study, transcriptome analysis revealed that enhanced glucocorticoid exposure normalized the expression of a substantial fraction of genes in the cotyledons. In contrast, a significant reduction in the multiple signaling pathway activities, including interferon signaling, was found in the caruncles during induced parturition. Real-time PCR showed that the expression of interferon-tau in the caruncles, but not interferon-alpha or interferon-gamma, was significantly lower in induced parturition than spontaneous parturition. Interferon-stimulated gene expression was also significantly decreased in the caruncles during induced parturition. These results indicate that interferon signaling could be important for immunological control in placentomes during parturition. Additionally, this suggests that interferon-tau might be a pivotal ligand for interferon receptors in the caruncles. This study revealed that peripheral blood leukocytes in prepartum cows transcribed interferon-tau. Macrophage infiltration in the placentome is known to participate in the detachment of the fetal membrane from the caruncle. Thus, this study raised the possibility that immune cells migrating into the caruncles at parturition may act as a source of ligands that activate interferon signaling.</p>
DOI： 10.1262/jrd.2021-094
Books and Other Publications 【 display / non-display 】
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Borboroglu Pablo Garcia, Boersma P. Dee, 上田 一生, 大久保 倫子, 牧尾 依里, 松岡 知祥子（ Role： Joint translator）
青土社 2022.05 （ ISBN:9784791774678 ）
Language：Japanese Book type：General book, introductory book for general audience
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動物の衛生 第2版
末吉益雄、髙井伸二編（ Role： Contributor）
文永堂出版 2020.03
Language：Japanese Book type：Scholarly book
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Dairy PROFESSIONAL Vol.4 特集 乳牛の栄養学ウルトラライト版～牛舎でわかる乳牛栄養学～
増子孝義、大久保倫子、他13名（ Role： Joint author , p78-85）
株式会社 デイリー・ジャパン社 2016.02
Language：Japanese Book type：General book, introductory book for general audience
Scientific Research Funds Acquisition Results 【 display / non-display 】
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ニホンジカの色覚特性の解明と農業被害軽減への応用
2019 - 2023
科学研究費補助金 若手研究
大久保 倫子
Authorship：Principal investigator